Incidental Mutation 'R6663:Kifc1'
ID 526893
Institutional Source Beutler Lab
Gene Symbol Kifc1
Ensembl Gene ENSMUSG00000079553
Gene Name kinesin family member C1
Synonyms Tctex7a, Tctex7, HSET, kinesin family c-terminal 5A, Tctex-7, KNSL2, Knsl2a, Tctex-7A, Gm4137, Kifc5a
MMRRC Submission 044783-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6663 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 34094640-34109607 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 34100430 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000133758 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114361] [ENSMUST00000173386] [ENSMUST00000173492]
AlphaFold Q9QWT9
Predicted Effect silent
Transcript: ENSMUST00000114361
SMART Domains Protein: ENSMUSP00000110001
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
low complexity region 65 76 N/A INTRINSIC
Blast:KISc 82 155 2e-12 BLAST
low complexity region 156 179 N/A INTRINSIC
KISc 246 609 1.77e-143 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172608
Predicted Effect probably benign
Transcript: ENSMUST00000173386
SMART Domains Protein: ENSMUSP00000133758
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
Blast:KISc 67 204 4e-31 BLAST
low complexity region 206 218 N/A INTRINSIC
Predicted Effect silent
Transcript: ENSMUST00000173492
SMART Domains Protein: ENSMUSP00000134572
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
low complexity region 108 119 N/A INTRINSIC
low complexity region 224 242 N/A INTRINSIC
KISc 309 672 1.77e-143 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173885
Predicted Effect unknown
Transcript: ENSMUST00000173982
AA Change: S59P
SMART Domains Protein: ENSMUSP00000133520
Gene: ENSMUSG00000079553
AA Change: S59P

DomainStartEndE-ValueType
Blast:KISc 2 44 8e-22 BLAST
PDB:2REP|A 2 51 6e-20 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174507
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd17 A G 5: 90,411,923 (GRCm39) S1314P probably damaging Het
Btbd3 T A 2: 138,121,003 (GRCm39) I59K probably benign Het
Clcn2 A G 16: 20,521,995 (GRCm39) *865R probably null Het
Col22a1 T C 15: 71,691,908 (GRCm39) Q749R unknown Het
Cpsf2 T C 12: 101,965,852 (GRCm39) Y606H probably damaging Het
Csn1s1 T C 5: 87,823,599 (GRCm39) V154A probably benign Het
Cux1 T A 5: 136,514,701 (GRCm39) E23V probably damaging Het
Cyp2j9 C A 4: 96,467,679 (GRCm39) W269L probably benign Het
Dbf4 T C 5: 8,453,184 (GRCm39) M273V probably benign Het
Dnhd1 A G 7: 105,334,899 (GRCm39) probably null Het
Fezf1 A G 6: 23,247,527 (GRCm39) S183P probably damaging Het
Irx2 A G 13: 72,777,248 (GRCm39) Y23C probably damaging Het
Itga1 A T 13: 115,110,641 (GRCm39) N983K probably benign Het
Lrrc14b T C 13: 74,509,480 (GRCm39) N309S probably damaging Het
Lyst A T 13: 13,838,701 (GRCm39) probably null Het
Map1b T C 13: 99,566,530 (GRCm39) T2064A unknown Het
Mark3 T A 12: 111,541,517 (GRCm39) N11K probably benign Het
Med6 T A 12: 81,628,649 (GRCm39) D80V possibly damaging Het
Mfhas1 A G 8: 36,056,272 (GRCm39) E249G probably damaging Het
Mroh2b A G 15: 4,977,417 (GRCm39) I1256M probably benign Het
Nkx2-9 G T 12: 56,658,723 (GRCm39) R164S probably benign Het
Or4p20 T A 2: 88,253,694 (GRCm39) N225I probably benign Het
Phf10 T C 17: 15,179,774 (GRCm39) D33G probably null Het
Plekha5 A G 6: 140,523,016 (GRCm39) M719V probably damaging Het
Pln A G 10: 53,219,792 (GRCm39) probably benign Het
Prg4 G A 1: 150,330,852 (GRCm39) probably benign Het
Slc35b3 A G 13: 39,138,112 (GRCm39) L99P probably damaging Het
Tbccd1 AT ATGT 16: 22,652,778 (GRCm39) probably null Het
Ube2j1 C T 4: 33,045,198 (GRCm39) S157L probably damaging Het
Zfp462 A G 4: 55,008,933 (GRCm39) T300A possibly damaging Het
Zfp668 G A 7: 127,466,941 (GRCm39) R212C probably damaging Het
Zup1 A G 10: 33,825,431 (GRCm39) M17T possibly damaging Het
Other mutations in Kifc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02707:Kifc1 APN 17 34,100,467 (GRCm39) nonsense probably null
R0540:Kifc1 UTSW 17 34,105,621 (GRCm39) missense probably damaging 0.98
R0607:Kifc1 UTSW 17 34,105,621 (GRCm39) missense probably damaging 0.98
R1019:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1218:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1219:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1222:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1374:Kifc1 UTSW 17 34,102,849 (GRCm39) missense probably benign 0.12
R1523:Kifc1 UTSW 17 34,102,636 (GRCm39) missense probably benign 0.23
R1818:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1958:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1960:Kifc1 UTSW 17 34,103,561 (GRCm39) critical splice donor site probably null
R5439:Kifc1 UTSW 17 34,105,639 (GRCm39) missense probably damaging 1.00
R5941:Kifc1 UTSW 17 34,102,059 (GRCm39) splice site probably benign
R6643:Kifc1 UTSW 17 34,104,829 (GRCm39) missense probably benign 0.23
R6724:Kifc1 UTSW 17 34,105,707 (GRCm39) splice site probably null
R7033:Kifc1 UTSW 17 34,102,671 (GRCm39) missense probably damaging 1.00
R7498:Kifc1 UTSW 17 34,102,846 (GRCm39) missense probably benign
R7515:Kifc1 UTSW 17 34,103,777 (GRCm39) missense probably damaging 1.00
R7733:Kifc1 UTSW 17 34,102,543 (GRCm39) missense probably damaging 1.00
R7803:Kifc1 UTSW 17 34,103,714 (GRCm39) missense probably benign
R7947:Kifc1 UTSW 17 34,102,849 (GRCm39) missense probably benign 0.12
R8024:Kifc1 UTSW 17 34,102,177 (GRCm39) missense probably damaging 1.00
R8979:Kifc1 UTSW 17 34,102,228 (GRCm39) missense possibly damaging 0.56
R9259:Kifc1 UTSW 17 34,101,165 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- CATGATGGAGATGCTGCAGTG -3'
(R):5'- TTTTAAAAGGAAGGACTGTAGGACTAC -3'

Sequencing Primer
(F):5'- GTGTATTGAATACTCAGGCCCCAG -3'
(R):5'- CTGGAACTCACTTTGTAGACCAGG -3'
Posted On 2018-07-23