Incidental Mutation 'R6664:Ifitm7'
ID 526919
Institutional Source Beutler Lab
Gene Symbol Ifitm7
Ensembl Gene ENSMUSG00000065968
Gene Name interferon induced transmembrane protein 7
Synonyms Mil4, 4933438K12Rik
MMRRC Submission 044784-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R6664 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 13799566-13804731 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13801613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 49 (T49A)
Ref Sequence ENSEMBL: ENSMUSP00000113641 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056521] [ENSMUST00000117803] [ENSMUST00000118412] [ENSMUST00000131608] [ENSMUST00000178021]
AlphaFold G3X9Z2
Predicted Effect probably benign
Transcript: ENSMUST00000056521
SMART Domains Protein: ENSMUSP00000062758
Gene: ENSMUSG00000044117

DomainStartEndE-ValueType
DUF3585 10 149 5.68e-39 SMART
low complexity region 170 181 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000117803
AA Change: T49A

PolyPhen 2 Score 0.128 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000113641
Gene: ENSMUSG00000065968
AA Change: T49A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:Dispanin 46 128 5.6e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118412
SMART Domains Protein: ENSMUSP00000112435
Gene: ENSMUSG00000044117

DomainStartEndE-ValueType
DUF3585 10 112 1.07e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131608
SMART Domains Protein: ENSMUSP00000122790
Gene: ENSMUSG00000044117

DomainStartEndE-ValueType
DUF3585 1 81 2.82e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178021
AA Change: T21A

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000136512
Gene: ENSMUSG00000065968
AA Change: T21A

DomainStartEndE-ValueType
Pfam:Dispanin 18 100 7.2e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230206
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm5 T C 4: 144,503,969 (GRCm39) *394W probably null Het
AU040320 A T 4: 126,729,443 (GRCm39) Y535F probably damaging Het
Auh G C 13: 53,052,703 (GRCm39) S138W probably damaging Het
Bmp2k A T 5: 97,235,989 (GRCm39) K1137N probably benign Het
Btn1a1 A G 13: 23,643,490 (GRCm39) Y320H probably benign Het
Ccdc18 C T 5: 108,315,966 (GRCm39) Q479* probably null Het
Cyp4f18 A T 8: 72,743,759 (GRCm39) S399T probably benign Het
Dcaf13 T C 15: 38,982,283 (GRCm39) L83P probably damaging Het
Fbxo45 T C 16: 32,057,234 (GRCm39) N220S probably damaging Het
Fbxw16 T C 9: 109,267,326 (GRCm39) M302V probably benign Het
Fgb A T 3: 82,954,066 (GRCm39) S57R probably damaging Het
Fryl A G 5: 73,289,824 (GRCm39) V134A probably damaging Het
Gatad2a A G 8: 70,370,139 (GRCm39) L189P probably damaging Het
Itih1 T C 14: 30,655,393 (GRCm39) T601A probably damaging Het
Jmjd4 T C 11: 59,341,245 (GRCm39) F59L probably benign Het
Magi2 C T 5: 20,907,395 (GRCm39) S1323L probably benign Het
Map3k21 A G 8: 126,668,610 (GRCm39) E732G probably benign Het
Nr4a3 G A 4: 48,056,006 (GRCm39) R344Q probably damaging Het
Or1j12 A G 2: 36,343,110 (GRCm39) N171S probably benign Het
Or52e5 T A 7: 104,719,395 (GRCm39) S240R possibly damaging Het
Pik3cb T C 9: 98,976,591 (GRCm39) T169A possibly damaging Het
Prl3a1 C A 13: 27,454,194 (GRCm39) Y57* probably null Het
Ripor2 A T 13: 24,859,803 (GRCm39) I164F probably damaging Het
Sik2 T C 9: 50,846,757 (GRCm39) E146G probably damaging Het
Szt2 G A 4: 118,248,942 (GRCm39) R581C probably damaging Het
Tango6 T A 8: 107,468,746 (GRCm39) D747E probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfp945 A G 17: 23,071,339 (GRCm39) S187P probably damaging Het
Other mutations in Ifitm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02271:Ifitm7 APN 16 13,801,541 (GRCm39) missense probably damaging 0.97
PIT4283001:Ifitm7 UTSW 16 13,801,471 (GRCm39) missense probably damaging 0.98
R7129:Ifitm7 UTSW 16 13,801,600 (GRCm39) missense possibly damaging 0.92
R7794:Ifitm7 UTSW 16 13,801,610 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GAGGATCAGGCAGCTGATGTTC -3'
(R):5'- GCTGGACAGATGAAACAGACCC -3'

Sequencing Primer
(F):5'- AGCTGATGTTCAGGCACCTG -3'
(R):5'- CCCTGTTGGAGAAAAGGCCAC -3'
Posted On 2018-07-23