Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01116:Or4k15b'

52701

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4k15b

Ensembl Gene

ENSMUSG00000068437

Gene Name

olfactory receptor family 4 subfamily K member 15B

Synonyms

GA_x6K02T2PMLR-5725741-5724776, MOR246-7_p, Olfr725, MOR246-3

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL01116

Quality Score

Status

Chromosome

Chromosomal Location

50271771-50277832 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 50272507 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 118 (M118L)

Ref Sequence

ENSEMBL: ENSMUSP00000145828 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089844] [ENSMUST00000206920]

AlphaFold

Q05A45

Predicted Effect

probably benign
Transcript: ENSMUST00000089844
AA Change: M118L

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000087282
Gene: ENSMUSG00000068437
AA Change: M118L

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	304	4.7e-46	PFAM
Pfam:7TM_GPCR_Srsx	36	282	1.8e-7	PFAM
Pfam:7tm_1	41	287	5.8e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000206920
AA Change: M118L

PolyPhen 2 Score 0.292 (Sensitivity: 0.91; Specificity: 0.89)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	T	A	12: 118,849,911 (GRCm39)	M951L	probably benign	Het
Als2	T	C	1: 59,225,163 (GRCm39)		probably benign	Het
Arhgap26	T	C	18: 39,244,856 (GRCm39)	V167A	probably damaging	Het
Bbs1	A	G	19: 4,952,867 (GRCm39)		probably benign	Het
Capn11	A	T	17: 45,949,806 (GRCm39)		probably benign	Het
Cenpl	G	T	1: 160,910,857 (GRCm39)	S268I	possibly damaging	Het
Coq8b	T	C	7: 26,939,282 (GRCm39)	V144A	possibly damaging	Het
Exo1	T	A	1: 175,728,963 (GRCm39)	C10S	possibly damaging	Het
Fam193b	A	T	13: 55,691,266 (GRCm39)	S203T	probably damaging	Het
Ggact	T	C	14: 123,129,167 (GRCm39)	N16S	probably damaging	Het
Gm3940	A	T	1: 52,129,882 (GRCm39)		probably benign	Het
Gm5458	G	T	14: 19,649,760 (GRCm39)	L155I	probably damaging	Het
Golm1	T	C	13: 59,797,470 (GRCm39)	K125R	probably damaging	Het
Gpatch4	A	G	3: 87,962,312 (GRCm39)	E175G	probably damaging	Het
Gria1	A	G	11: 57,127,801 (GRCm39)	N337D	probably damaging	Het
Gripap1	G	A	X: 7,678,705 (GRCm39)	G464D	probably benign	Het
Grk1	A	G	8: 13,455,404 (GRCm39)	D96G	possibly damaging	Het
Hsf1	T	C	15: 76,382,403 (GRCm39)	V258A	probably benign	Het
Ighv7-4	A	G	12: 114,186,653 (GRCm39)	S40P	probably damaging	Het
Igkv4-50	G	A	6: 69,677,921 (GRCm39)	S61L	probably benign	Het
Igkv4-62	C	T	6: 69,377,035 (GRCm39)	G38E	probably damaging	Het
Ints1	T	C	5: 139,757,437 (GRCm39)	D358G	probably damaging	Het
Madd	A	G	2: 90,984,888 (GRCm39)		probably benign	Het
Map3k6	A	G	4: 132,974,439 (GRCm39)	S580G	probably damaging	Het
Myef2	A	G	2: 124,940,402 (GRCm39)	M383T	probably damaging	Het
Myo3b	T	C	2: 70,119,730 (GRCm39)	L930P	probably damaging	Het
Ndufaf3	C	T	9: 108,444,068 (GRCm39)	R20Q	probably benign	Het
Npr2	T	C	4: 43,640,248 (GRCm39)	S328P	probably damaging	Het
Or1r1	A	T	11: 73,875,144 (GRCm39)	C97S	probably damaging	Het
Pdpr	T	C	8: 111,839,342 (GRCm39)	I155T	possibly damaging	Het
Phf11b	A	T	14: 59,560,631 (GRCm39)	I216K	probably benign	Het
Phkg1	T	C	5: 129,893,813 (GRCm39)		probably null	Het
Pik3r6	A	G	11: 68,422,276 (GRCm39)	Y225C	probably benign	Het
Plekhh2	A	T	17: 84,914,356 (GRCm39)	D1253V	possibly damaging	Het
Plppr3	T	C	10: 79,702,757 (GRCm39)	T155A	probably damaging	Het
Ppp6r2	T	C	15: 89,166,192 (GRCm39)	F732S	probably damaging	Het
Ryr1	A	G	7: 28,799,627 (GRCm39)		probably benign	Het
Slc16a8	T	G	15: 79,135,432 (GRCm39)	S459R	probably damaging	Het
Slc25a12	A	T	2: 71,123,696 (GRCm39)		probably benign	Het
Slc38a2	T	C	15: 96,591,066 (GRCm39)		probably benign	Het
Slit1	C	A	19: 41,594,824 (GRCm39)	W1182L	possibly damaging	Het
Snx2	C	T	18: 53,327,495 (GRCm39)		probably benign	Het
Sos1	A	T	17: 80,752,929 (GRCm39)	V335D	probably damaging	Het
St18	A	G	1: 6,872,856 (GRCm39)	D197G	probably damaging	Het
Ston2	G	T	12: 91,615,522 (GRCm39)	N295K	possibly damaging	Het
Stpg3	A	G	2: 25,103,191 (GRCm39)		probably benign	Het
Tmem63a	A	G	1: 180,799,654 (GRCm39)	I675V	probably damaging	Het
Vmn2r16	T	A	5: 109,488,294 (GRCm39)	L389Q	probably damaging	Het
Vps13d	C	A	4: 144,699,320 (GRCm39)		probably benign	Het
Wdfy4	A	T	14: 32,681,934 (GRCm39)	D3012E	probably damaging	Het

Other mutations in Or4k15b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01412:Or4k15b	APN	14	50,272,770 (GRCm39)	missense	probably benign
IGL03241:Or4k15b	APN	14	50,272,525 (GRCm39)	missense	possibly damaging	0.70
IGL03268:Or4k15b	APN	14	50,272,024 (GRCm39)	missense	probably damaging	0.98
IGL03348:Or4k15b	APN	14	50,272,212 (GRCm39)	missense	probably benign	0.00
R0358:Or4k15b	UTSW	14	50,272,743 (GRCm39)	missense	probably damaging	0.97
R0577:Or4k15b	UTSW	14	50,272,249 (GRCm39)	missense	probably damaging	1.00
R2094:Or4k15b	UTSW	14	50,272,171 (GRCm39)	missense	probably damaging	1.00
R2424:Or4k15b	UTSW	14	50,272,281 (GRCm39)	missense	probably damaging	1.00
R3421:Or4k15b	UTSW	14	50,271,997 (GRCm39)	missense	possibly damaging	0.66
R3422:Or4k15b	UTSW	14	50,271,997 (GRCm39)	missense	possibly damaging	0.66
R4436:Or4k15b	UTSW	14	50,272,287 (GRCm39)	missense	probably damaging	1.00
R4437:Or4k15b	UTSW	14	50,272,287 (GRCm39)	missense	probably damaging	1.00
R4438:Or4k15b	UTSW	14	50,272,287 (GRCm39)	missense	probably damaging	1.00
R4684:Or4k15b	UTSW	14	50,272,287 (GRCm39)	missense	probably damaging	1.00
R4717:Or4k15b	UTSW	14	50,272,821 (GRCm39)	missense	probably damaging	0.98
R5253:Or4k15b	UTSW	14	50,272,745 (GRCm39)	missense	possibly damaging	0.91
R5254:Or4k15b	UTSW	14	50,272,135 (GRCm39)	missense	possibly damaging	0.60
R5641:Or4k15b	UTSW	14	50,272,746 (GRCm39)	missense	probably benign	0.04
R5881:Or4k15b	UTSW	14	50,272,444 (GRCm39)	missense	probably benign	0.00
R5906:Or4k15b	UTSW	14	50,272,306 (GRCm39)	missense	probably benign	0.05
R6511:Or4k15b	UTSW	14	50,272,266 (GRCm39)	missense	probably damaging	1.00
R7837:Or4k15b	UTSW	14	50,272,033 (GRCm39)	missense	probably damaging	1.00
R7980:Or4k15b	UTSW	14	50,272,252 (GRCm39)	missense	probably damaging	1.00
R8118:Or4k15b	UTSW	14	50,272,608 (GRCm39)	missense	probably benign	0.13
R8942:Or4k15b	UTSW	14	50,272,602 (GRCm39)	missense	probably damaging	1.00
R9084:Or4k15b	UTSW	14	50,271,916 (GRCm39)	missense	probably benign
R9797:Or4k15b	UTSW	14	50,272,224 (GRCm39)	missense	probably benign	0.19
X0062:Or4k15b	UTSW	14	50,272,317 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21