Incidental Mutation 'R6667:Prl7a2'
ID 527035
Institutional Source Beutler Lab
Gene Symbol Prl7a2
Ensembl Gene ENSMUSG00000046899
Gene Name prolactin family 7, subfamily a, member 2
Synonyms PLP-F, Prlpf
MMRRC Submission 044787-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6667 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 27658584-27668036 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27661041 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 121 (N121D)
Ref Sequence ENSEMBL: ENSMUSP00000006660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006660]
AlphaFold O54831
Predicted Effect probably benign
Transcript: ENSMUST00000006660
AA Change: N121D

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000006660
Gene: ENSMUSG00000046899
AA Change: N121D

DomainStartEndE-ValueType
Pfam:Hormone_1 17 244 6.9e-45 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.6%
Validation Efficiency 98% (41/42)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3100002H09Rik G T 4: 124,610,642 (GRCm38) A39E probably damaging Het
Agtr1b T A 3: 20,315,749 (GRCm38) N231I possibly damaging Het
Alpk2 T C 18: 65,307,740 (GRCm38) E661G probably damaging Het
Ankrd26 C T 6: 118,507,788 (GRCm38) S1496N probably benign Het
Asah2 T C 19: 31,995,358 (GRCm38) N659S probably benign Het
Atp12a T C 14: 56,384,188 (GRCm38) V760A possibly damaging Het
Casp2 T C 6: 42,279,836 (GRCm38) C343R probably damaging Het
Cblb T A 16: 52,152,644 (GRCm38) M446K possibly damaging Het
Cipc T C 12: 86,962,090 (GRCm38) V241A probably benign Het
Ddit4l A G 3: 137,626,121 (GRCm38) K83E probably benign Het
E430018J23Rik A G 7: 127,393,423 (GRCm38) M5T probably benign Het
Epc2 A G 2: 49,522,669 (GRCm38) T220A probably damaging Het
Epha5 T C 5: 84,071,191 (GRCm38) D741G probably damaging Het
Flg2 A T 3: 93,201,761 (GRCm38) R365S possibly damaging Het
Ggn A T 7: 29,172,668 (GRCm38) H491L possibly damaging Het
Gm21119 T C 8: 20,621,939 (GRCm38) S267P probably benign Het
Gm8332 A T 12: 88,249,705 (GRCm38) D132E unknown Het
Gpat2 G C 2: 127,431,918 (GRCm38) G294R possibly damaging Het
Ighv6-4 A G 12: 114,406,532 (GRCm38) V100A probably benign Het
Invs A T 4: 48,402,870 (GRCm38) Y501F possibly damaging Het
Iqcm G T 8: 75,753,352 (GRCm38) G313W probably damaging Het
Jph2 A G 2: 163,376,286 (GRCm38) S157P probably damaging Het
Mast4 T C 13: 102,737,496 (GRCm38) E1596G probably damaging Het
Mllt6 T A 11: 97,676,934 (GRCm38) L759Q probably damaging Het
Nalcn A G 14: 123,321,323 (GRCm38) L837P probably damaging Het
Neb G A 2: 52,147,189 (GRCm38) T6836I probably damaging Het
Nol12 T A 15: 78,940,080 (GRCm38) D133E probably benign Het
Olfr1136 A G 2: 87,693,570 (GRCm38) V104A probably benign Het
Oxtr C A 6: 112,477,099 (GRCm38) probably benign Het
Pcmt1 A G 10: 7,663,149 (GRCm38) L38P probably damaging Het
Pik3r2 T C 8: 70,769,173 (GRCm38) Y617C probably damaging Het
Pvr G T 7: 19,905,802 (GRCm38) Q380K probably benign Het
Rtn2 A G 7: 19,287,259 (GRCm38) E188G probably benign Het
Setd4 C A 16: 93,590,030 (GRCm38) R260L probably benign Het
Six5 A G 7: 19,096,569 (GRCm38) N374D probably benign Het
Slc9b1 T C 3: 135,371,965 (GRCm38) I140T probably damaging Het
Supt16 A G 14: 52,172,063 (GRCm38) F797L probably damaging Het
Tbata T C 10: 61,185,363 (GRCm38) L262P probably damaging Het
Tti1 A T 2: 158,008,427 (GRCm38) C297* probably null Het
Ush1c C A 7: 46,225,624 (GRCm38) G139C probably damaging Het
Vmn1r1 C T 1: 182,157,777 (GRCm38) V108I probably benign Het
Vmn2r116 C T 17: 23,401,092 (GRCm38) T600I probably damaging Het
Zfp873 A G 10: 82,060,589 (GRCm38) T422A probably benign Het
Zfp943 G A 17: 21,992,908 (GRCm38) C325Y probably damaging Het
Other mutations in Prl7a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01484:Prl7a2 APN 13 27,659,208 (GRCm38) missense probably damaging 0.98
IGL02424:Prl7a2 APN 13 27,667,970 (GRCm38) missense probably null 0.08
IGL02734:Prl7a2 APN 13 27,659,207 (GRCm38) missense probably benign 0.38
IGL02823:Prl7a2 APN 13 27,662,751 (GRCm38) missense possibly damaging 0.95
PIT4260001:Prl7a2 UTSW 13 27,659,276 (GRCm38) nonsense probably null
R0733:Prl7a2 UTSW 13 27,662,688 (GRCm38) missense probably damaging 1.00
R1371:Prl7a2 UTSW 13 27,662,767 (GRCm38) missense probably benign 0.01
R1778:Prl7a2 UTSW 13 27,659,271 (GRCm38) missense probably damaging 0.98
R1857:Prl7a2 UTSW 13 27,659,180 (GRCm38) nonsense probably null
R2063:Prl7a2 UTSW 13 27,660,887 (GRCm38) missense probably damaging 0.98
R2064:Prl7a2 UTSW 13 27,660,887 (GRCm38) missense probably damaging 0.98
R2065:Prl7a2 UTSW 13 27,660,887 (GRCm38) missense probably damaging 0.98
R2067:Prl7a2 UTSW 13 27,660,887 (GRCm38) missense probably damaging 0.98
R2068:Prl7a2 UTSW 13 27,660,887 (GRCm38) missense probably damaging 0.98
R2176:Prl7a2 UTSW 13 27,659,106 (GRCm38) missense probably benign 0.10
R2213:Prl7a2 UTSW 13 27,665,068 (GRCm38) missense probably benign 0.06
R4111:Prl7a2 UTSW 13 27,665,067 (GRCm38) missense possibly damaging 0.96
R4459:Prl7a2 UTSW 13 27,665,996 (GRCm38) missense probably benign 0.21
R4483:Prl7a2 UTSW 13 27,660,947 (GRCm38) missense possibly damaging 0.80
R4722:Prl7a2 UTSW 13 27,660,875 (GRCm38) missense probably damaging 1.00
R5360:Prl7a2 UTSW 13 27,659,160 (GRCm38) missense probably benign 0.22
R5778:Prl7a2 UTSW 13 27,661,000 (GRCm38) nonsense probably null
R7107:Prl7a2 UTSW 13 27,659,093 (GRCm38) missense possibly damaging 0.89
R7600:Prl7a2 UTSW 13 27,659,281 (GRCm38) missense possibly damaging 0.63
R8298:Prl7a2 UTSW 13 27,661,011 (GRCm38) missense probably benign 0.00
R8447:Prl7a2 UTSW 13 27,665,958 (GRCm38) missense possibly damaging 0.72
R9009:Prl7a2 UTSW 13 27,666,011 (GRCm38) missense probably damaging 1.00
R9331:Prl7a2 UTSW 13 27,665,079 (GRCm38) missense probably damaging 1.00
R9624:Prl7a2 UTSW 13 27,665,886 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CACCGAGTTGAGTATACTCTGG -3'
(R):5'- GGTCTAATGTCAGAATTGCATATGC -3'

Sequencing Primer
(F):5'- CTGGGTGTACTCAAAAAGCTCTGC -3'
(R):5'- GCTTGTCTCATAGAAAACCAA -3'
Posted On 2018-07-23