Incidental Mutation 'R6668:Fmo2'
ID 527048
Institutional Source Beutler Lab
Gene Symbol Fmo2
Ensembl Gene ENSMUSG00000040170
Gene Name flavin containing monooxygenase 2
Synonyms 2310042I22Rik, 2310008D08Rik
MMRRC Submission 044788-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R6668 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 162701886-162726295 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 162704617 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 430 (T430S)
Ref Sequence ENSEMBL: ENSMUSP00000107135 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045902] [ENSMUST00000111510]
AlphaFold Q8K2I3
Predicted Effect probably benign
Transcript: ENSMUST00000045902
AA Change: T430S

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000044405
Gene: ENSMUSG00000040170
AA Change: T430S

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 3 230 6.4e-12 PFAM
Pfam:Pyr_redox_3 6 220 4.4e-10 PFAM
Pfam:K_oxygenase 69 233 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111510
AA Change: T430S

PolyPhen 2 Score 0.152 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000107135
Gene: ENSMUSG00000040170
AA Change: T430S

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 4 446 1.3e-6 PFAM
Pfam:Pyr_redox_3 6 220 8e-17 PFAM
Pfam:NAD_binding_8 7 72 4.3e-6 PFAM
Pfam:K_oxygenase 78 333 1.3e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194061
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194197
Meta Mutation Damage Score 0.0899 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat G T 11: 116,486,868 (GRCm39) probably benign Het
Adam26b A T 8: 43,973,727 (GRCm39) V425D possibly damaging Het
Ahctf1 A G 1: 179,579,972 (GRCm39) S2077P probably benign Het
Amacr A G 15: 10,983,468 (GRCm39) T93A probably benign Het
Arsb T A 13: 93,930,728 (GRCm39) probably null Het
Bcas3 G A 11: 85,692,677 (GRCm39) R354Q probably damaging Het
Chia1 C T 3: 106,038,264 (GRCm39) L387F probably damaging Het
Cyp24a1 A T 2: 170,327,805 (GRCm39) probably null Het
Dennd4a G A 9: 64,794,247 (GRCm39) G689S probably damaging Het
Elovl4 G A 9: 83,688,039 (GRCm39) A18V probably benign Het
Fam135a A T 1: 24,067,929 (GRCm39) V80E probably damaging Het
Fpgs T C 2: 32,577,618 (GRCm39) I213V probably benign Het
Gm10134 A T 2: 28,396,263 (GRCm39) R53* probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Ift172 T C 5: 31,412,683 (GRCm39) N1524S probably benign Het
Kif1b G A 4: 149,297,864 (GRCm39) S1104F probably benign Het
Map3k21 T C 8: 126,652,852 (GRCm39) V326A possibly damaging Het
Mlst8 A G 17: 24,696,453 (GRCm39) probably null Het
Muc16 A T 9: 18,551,681 (GRCm39) S4871T probably benign Het
Myo1d A G 11: 80,474,701 (GRCm39) probably benign Het
Ndufa3 A G 7: 3,622,465 (GRCm39) Y41C probably damaging Het
Nfkbid T A 7: 30,123,866 (GRCm39) L142Q probably benign Het
Or8b38 T A 9: 37,973,066 (GRCm39) M150K possibly damaging Het
Peg10 T A 6: 4,754,502 (GRCm39) D94E probably benign Het
Phactr3 A T 2: 177,974,657 (GRCm39) I492F probably damaging Het
Plxna2 T C 1: 194,492,396 (GRCm39) V1751A possibly damaging Het
Prss16 T C 13: 22,190,918 (GRCm39) E238G probably null Het
Rad51ap2 T C 12: 11,507,647 (GRCm39) V523A probably benign Het
Rbm33 T A 5: 28,547,498 (GRCm39) S223T probably benign Het
Ryk T A 9: 102,746,475 (GRCm39) F137I possibly damaging Het
Sars2 G A 7: 28,446,429 (GRCm39) E194K probably benign Het
Spata2l T C 8: 123,960,167 (GRCm39) D374G probably damaging Het
Tenm2 A G 11: 35,937,592 (GRCm39) probably null Het
Ubr4 A G 4: 139,192,652 (GRCm39) K1097E probably damaging Het
Ulk4 A T 9: 121,017,408 (GRCm39) V690E probably damaging Het
Usp34 A G 11: 23,410,659 (GRCm39) N2703S probably damaging Het
Zfp273 C G 13: 67,973,243 (GRCm39) L124V probably damaging Het
Zfp608 A G 18: 55,031,091 (GRCm39) S950P probably damaging Het
Zfp994 A T 17: 22,420,081 (GRCm39) H289Q probably damaging Het
Other mutations in Fmo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00715:Fmo2 APN 1 162,716,282 (GRCm39) nonsense probably null
IGL01299:Fmo2 APN 1 162,705,599 (GRCm39) missense probably benign
IGL02617:Fmo2 APN 1 162,704,490 (GRCm39) missense probably damaging 1.00
IGL02994:Fmo2 APN 1 162,708,189 (GRCm39) missense probably damaging 1.00
IGL03270:Fmo2 APN 1 162,709,595 (GRCm39) missense probably damaging 1.00
F5493:Fmo2 UTSW 1 162,708,101 (GRCm39) missense probably benign 0.41
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0501:Fmo2 UTSW 1 162,704,497 (GRCm39) missense probably benign 0.00
R0658:Fmo2 UTSW 1 162,704,343 (GRCm39) missense possibly damaging 0.57
R0800:Fmo2 UTSW 1 162,704,383 (GRCm39) missense probably benign 0.00
R2223:Fmo2 UTSW 1 162,725,813 (GRCm39) missense probably damaging 1.00
R4360:Fmo2 UTSW 1 162,709,583 (GRCm39) missense probably damaging 0.99
R4523:Fmo2 UTSW 1 162,715,277 (GRCm39) missense probably benign 0.44
R4755:Fmo2 UTSW 1 162,716,374 (GRCm39) missense probably damaging 1.00
R6087:Fmo2 UTSW 1 162,708,002 (GRCm39) missense probably benign 0.45
R6219:Fmo2 UTSW 1 162,708,085 (GRCm39) missense probably damaging 0.97
R7042:Fmo2 UTSW 1 162,708,226 (GRCm39) missense probably damaging 1.00
R7291:Fmo2 UTSW 1 162,715,271 (GRCm39) missense probably benign 0.06
R7560:Fmo2 UTSW 1 162,716,318 (GRCm39) missense probably damaging 1.00
R7580:Fmo2 UTSW 1 162,704,613 (GRCm39) missense possibly damaging 0.46
R7657:Fmo2 UTSW 1 162,716,413 (GRCm39) missense probably damaging 1.00
R8757:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8759:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8765:Fmo2 UTSW 1 162,707,966 (GRCm39) missense probably benign 0.36
R8925:Fmo2 UTSW 1 162,704,398 (GRCm39) missense probably benign 0.00
R8927:Fmo2 UTSW 1 162,704,398 (GRCm39) missense probably benign 0.00
R9002:Fmo2 UTSW 1 162,705,647 (GRCm39) nonsense probably null
R9141:Fmo2 UTSW 1 162,709,623 (GRCm39) missense probably null 0.01
R9486:Fmo2 UTSW 1 162,708,292 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,725,843 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,715,167 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGGTTTCAGGATCCTCTGCTTC -3'
(R):5'- ATCTGAGATACAAACCTCCTGATGG -3'

Sequencing Primer
(F):5'- CAGGATCCTCTGCTTCTGGGTG -3'
(R):5'- TGATGGAACCTCCCAGAGATTCATTC -3'
Posted On 2018-07-23