Incidental Mutation 'R6668:Gm10134'
ID 527051
Institutional Source Beutler Lab
Gene Symbol Gm10134
Ensembl Gene ENSMUSG00000063611
Gene Name predicted gene 10134
Synonyms
MMRRC Submission 044788-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6668 (G1)
Quality Score 134.008
Status Validated
Chromosome 2
Chromosomal Location 28396107-28397785 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 28396263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 53 (R53*)
Ref Sequence ENSEMBL: ENSMUSP00000082978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028172] [ENSMUST00000074761] [ENSMUST00000163121]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000028172
SMART Domains Protein: ENSMUSP00000028172
Gene: ENSMUSG00000026829

DomainStartEndE-ValueType
transmembrane domain 7 24 N/A INTRINSIC
Pfam:Glyco_transf_6 33 347 1.6e-154 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000074761
AA Change: R53*
SMART Domains Protein: ENSMUSP00000082978
Gene: ENSMUSG00000063611
AA Change: R53*

DomainStartEndE-ValueType
transmembrane domain 5 27 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127958
Predicted Effect probably benign
Transcript: ENSMUST00000163121
SMART Domains Protein: ENSMUSP00000127071
Gene: ENSMUSG00000026829

DomainStartEndE-ValueType
Pfam:Glyco_transf_6 11 347 1.9e-152 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aanat G T 11: 116,486,868 (GRCm39) probably benign Het
Adam26b A T 8: 43,973,727 (GRCm39) V425D possibly damaging Het
Ahctf1 A G 1: 179,579,972 (GRCm39) S2077P probably benign Het
Amacr A G 15: 10,983,468 (GRCm39) T93A probably benign Het
Arsb T A 13: 93,930,728 (GRCm39) probably null Het
Bcas3 G A 11: 85,692,677 (GRCm39) R354Q probably damaging Het
Chia1 C T 3: 106,038,264 (GRCm39) L387F probably damaging Het
Cyp24a1 A T 2: 170,327,805 (GRCm39) probably null Het
Dennd4a G A 9: 64,794,247 (GRCm39) G689S probably damaging Het
Elovl4 G A 9: 83,688,039 (GRCm39) A18V probably benign Het
Fam135a A T 1: 24,067,929 (GRCm39) V80E probably damaging Het
Fmo2 T A 1: 162,704,617 (GRCm39) T430S probably benign Het
Fpgs T C 2: 32,577,618 (GRCm39) I213V probably benign Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Ift172 T C 5: 31,412,683 (GRCm39) N1524S probably benign Het
Kif1b G A 4: 149,297,864 (GRCm39) S1104F probably benign Het
Map3k21 T C 8: 126,652,852 (GRCm39) V326A possibly damaging Het
Mlst8 A G 17: 24,696,453 (GRCm39) probably null Het
Muc16 A T 9: 18,551,681 (GRCm39) S4871T probably benign Het
Myo1d A G 11: 80,474,701 (GRCm39) probably benign Het
Ndufa3 A G 7: 3,622,465 (GRCm39) Y41C probably damaging Het
Nfkbid T A 7: 30,123,866 (GRCm39) L142Q probably benign Het
Or8b38 T A 9: 37,973,066 (GRCm39) M150K possibly damaging Het
Peg10 T A 6: 4,754,502 (GRCm39) D94E probably benign Het
Phactr3 A T 2: 177,974,657 (GRCm39) I492F probably damaging Het
Plxna2 T C 1: 194,492,396 (GRCm39) V1751A possibly damaging Het
Prss16 T C 13: 22,190,918 (GRCm39) E238G probably null Het
Rad51ap2 T C 12: 11,507,647 (GRCm39) V523A probably benign Het
Rbm33 T A 5: 28,547,498 (GRCm39) S223T probably benign Het
Ryk T A 9: 102,746,475 (GRCm39) F137I possibly damaging Het
Sars2 G A 7: 28,446,429 (GRCm39) E194K probably benign Het
Spata2l T C 8: 123,960,167 (GRCm39) D374G probably damaging Het
Tenm2 A G 11: 35,937,592 (GRCm39) probably null Het
Ubr4 A G 4: 139,192,652 (GRCm39) K1097E probably damaging Het
Ulk4 A T 9: 121,017,408 (GRCm39) V690E probably damaging Het
Usp34 A G 11: 23,410,659 (GRCm39) N2703S probably damaging Het
Zfp273 C G 13: 67,973,243 (GRCm39) L124V probably damaging Het
Zfp608 A G 18: 55,031,091 (GRCm39) S950P probably damaging Het
Zfp994 A T 17: 22,420,081 (GRCm39) H289Q probably damaging Het
Other mutations in Gm10134
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02431:Gm10134 APN 2 28,396,429 (GRCm39) unclassified probably benign
R2339:Gm10134 UTSW 2 28,396,141 (GRCm39) missense probably benign 0.34
R5288:Gm10134 UTSW 2 28,396,372 (GRCm39) unclassified probably benign
R5385:Gm10134 UTSW 2 28,396,372 (GRCm39) unclassified probably benign
R5994:Gm10134 UTSW 2 28,396,258 (GRCm39) missense probably damaging 0.98
R7594:Gm10134 UTSW 2 28,396,372 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TGCCAGTCTAGATAATTCTGGG -3'
(R):5'- TAGGTGTGGCACATCTGTCC -3'

Sequencing Primer
(F):5'- CCAGTCTAGATAATTCTGGGGAATAC -3'
(R):5'- TGTGGCACATCTGTCCACAGG -3'
Posted On 2018-07-23