Incidental Mutation 'IGL01125:Btd'
| ID |
52711 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Btd
|
| Ensembl Gene |
ENSMUSG00000021900 |
| Gene Name |
biotinidase |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.130)
|
| Stock # |
IGL01125
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
31363014-31390154 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 31389733 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Isoleucine
at position 485
(F485I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000087608
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090147]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090147
AA Change: F485I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000087608
Gene: ENSMUSG00000021900
AA Change: F485I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
34 |
N/A |
INTRINSIC |
|
Pfam:CN_hydrolase
|
63 |
287 |
3.9e-17 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128014
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit behavioral/neurological defects, weakness, bone loss, weight loss, and alopecia when fed a biotin-deprived diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrg2 |
C |
T |
X: 159,275,704 (GRCm39) |
T931I |
probably damaging |
Het |
| Atp5mc3 |
A |
G |
2: 73,741,293 (GRCm39) |
|
probably benign |
Het |
| Camk2d |
A |
G |
3: 126,591,934 (GRCm39) |
|
probably benign |
Het |
| Cd300lg |
A |
T |
11: 101,945,047 (GRCm39) |
|
probably benign |
Het |
| Col9a1 |
A |
G |
1: 24,263,726 (GRCm39) |
|
probably null |
Het |
| Cybb |
T |
A |
X: 9,312,983 (GRCm39) |
N367I |
possibly damaging |
Het |
| Dcaf17 |
T |
C |
2: 70,920,149 (GRCm39) |
V479A |
probably benign |
Het |
| Dscaml1 |
G |
T |
9: 45,660,930 (GRCm39) |
|
probably null |
Het |
| Espl1 |
T |
C |
15: 102,231,373 (GRCm39) |
F51S |
probably damaging |
Het |
| Gsdmc3 |
T |
A |
15: 63,733,306 (GRCm39) |
D258V |
probably benign |
Het |
| Gvin-ps3 |
A |
T |
7: 105,682,021 (GRCm39) |
N411K |
unknown |
Het |
| Ifngr1 |
C |
T |
10: 19,473,161 (GRCm39) |
|
probably benign |
Het |
| Kcnip1 |
A |
T |
11: 33,583,202 (GRCm39) |
D194E |
probably damaging |
Het |
| Lrrtm1 |
C |
T |
6: 77,221,436 (GRCm39) |
R298C |
probably damaging |
Het |
| Map3k4 |
G |
A |
17: 12,490,849 (GRCm39) |
S194L |
probably damaging |
Het |
| Mmp16 |
A |
G |
4: 18,112,066 (GRCm39) |
K481E |
possibly damaging |
Het |
| Myh1 |
A |
T |
11: 67,111,486 (GRCm39) |
M1642L |
probably benign |
Het |
| Nol9 |
G |
T |
4: 152,131,066 (GRCm39) |
C363F |
probably damaging |
Het |
| Nsd1 |
T |
C |
13: 55,393,430 (GRCm39) |
S344P |
probably damaging |
Het |
| Or52e5 |
A |
T |
7: 104,718,808 (GRCm39) |
I45F |
probably benign |
Het |
| Phf20 |
G |
A |
2: 156,145,104 (GRCm39) |
|
probably null |
Het |
| Ppp3cc |
G |
T |
14: 70,455,701 (GRCm39) |
H467Q |
probably damaging |
Het |
| Rab28 |
A |
G |
5: 41,793,237 (GRCm39) |
M136T |
probably benign |
Het |
| Rag1 |
A |
G |
2: 101,472,346 (GRCm39) |
I932T |
probably damaging |
Het |
| Sez6 |
T |
C |
11: 77,868,115 (GRCm39) |
|
probably benign |
Het |
| Slc49a3 |
A |
G |
5: 108,592,458 (GRCm39) |
|
probably benign |
Het |
| Sorcs1 |
T |
C |
19: 50,216,639 (GRCm39) |
T647A |
probably damaging |
Het |
| Sspo |
T |
A |
6: 48,469,822 (GRCm39) |
C4507S |
probably damaging |
Het |
| Traf3ip3 |
T |
C |
1: 192,866,772 (GRCm39) |
|
probably null |
Het |
| Vmn2r121 |
T |
A |
X: 123,042,504 (GRCm39) |
I218F |
probably damaging |
Het |
| Vmn2r61 |
A |
G |
7: 41,909,550 (GRCm39) |
Y25C |
probably damaging |
Het |
|
| Other mutations in Btd |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02728:Btd
|
APN |
14 |
31,389,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02965:Btd
|
APN |
14 |
31,389,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1503:Btd
|
UTSW |
14 |
31,389,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1662:Btd
|
UTSW |
14 |
31,388,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1817:Btd
|
UTSW |
14 |
31,384,246 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1868:Btd
|
UTSW |
14 |
31,389,266 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2225:Btd
|
UTSW |
14 |
31,389,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2418:Btd
|
UTSW |
14 |
31,363,093 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4660:Btd
|
UTSW |
14 |
31,389,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4727:Btd
|
UTSW |
14 |
31,384,278 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4923:Btd
|
UTSW |
14 |
31,384,044 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5703:Btd
|
UTSW |
14 |
31,389,004 (GRCm39) |
nonsense |
probably null |
|
|
R5806:Btd
|
UTSW |
14 |
31,389,469 (GRCm39) |
missense |
probably benign |
|
|
R6110:Btd
|
UTSW |
14 |
31,363,065 (GRCm39) |
unclassified |
probably benign |
|
|
R6119:Btd
|
UTSW |
14 |
31,363,065 (GRCm39) |
unclassified |
probably benign |
|
|
R6120:Btd
|
UTSW |
14 |
31,363,065 (GRCm39) |
unclassified |
probably benign |
|
|
R7019:Btd
|
UTSW |
14 |
31,389,063 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7019:Btd
|
UTSW |
14 |
31,389,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7021:Btd
|
UTSW |
14 |
31,389,788 (GRCm39) |
missense |
probably benign |
|
|
R7837:Btd
|
UTSW |
14 |
31,388,784 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8176:Btd
|
UTSW |
14 |
31,384,073 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8249:Btd
|
UTSW |
14 |
31,387,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8516:Btd
|
UTSW |
14 |
31,388,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9098:Btd
|
UTSW |
14 |
31,384,233 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9465:Btd
|
UTSW |
14 |
31,389,643 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation