Incidental Mutation 'R6675:Or51f2'
ID 527248
Institutional Source Beutler Lab
Gene Symbol Or51f2
Ensembl Gene ENSMUSG00000073965
Gene Name olfactory receptor family 51 subfamily F member 2
Synonyms MOR14-11, GA_x6K02T2PBJ9-5588278-5589228, MOR14-3, Olfr568
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R6675 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 102526329-102527270 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102526480 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 51 (E51G)
Ref Sequence ENSEMBL: ENSMUSP00000095818 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098216]
AlphaFold E9Q554
Predicted Effect possibly damaging
Transcript: ENSMUST00000098216
AA Change: E51G

PolyPhen 2 Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000095818
Gene: ENSMUSG00000073965
AA Change: E51G

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 7.6e-113 PFAM
Pfam:7TM_GPCR_Srsx 34 306 1.8e-7 PFAM
Pfam:7tm_1 40 291 1e-20 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,006,302 (GRCm39) T1268A probably benign Het
Adamts20 A G 15: 94,229,197 (GRCm39) probably null Het
Arhgap45 G T 10: 79,853,938 (GRCm39) D151Y probably null Het
Arhgef40 C A 14: 52,229,098 (GRCm39) L592I probably damaging Het
Ascc3 G T 10: 50,626,659 (GRCm39) E1720* probably null Het
Atp2c1 C T 9: 105,330,732 (GRCm39) probably null Het
Avpi1 G A 19: 42,112,183 (GRCm39) P125L probably benign Het
Cers3 A T 7: 66,435,844 (GRCm39) T232S possibly damaging Het
Cfap53 T C 18: 74,440,447 (GRCm39) probably null Het
Col4a3 T C 1: 82,646,646 (GRCm39) S386P unknown Het
Dhtkd1 A T 2: 5,908,889 (GRCm39) M735K probably damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Gad2 T C 2: 22,563,997 (GRCm39) V400A possibly damaging Het
Gm10801 TC TCGCC 2: 98,494,151 (GRCm39) probably benign Het
Hmgxb3 T G 18: 61,270,648 (GRCm39) D892A possibly damaging Het
Hsd3b2 G A 3: 98,620,788 (GRCm39) T89I probably benign Het
Iars1 C A 13: 49,873,054 (GRCm39) A713D probably damaging Het
Itih1 G A 14: 30,651,798 (GRCm39) T848I possibly damaging Het
Kcne2 A G 16: 92,093,512 (GRCm39) D13G probably benign Het
Klra17 T A 6: 129,849,286 (GRCm39) N96I probably damaging Het
Lrig2 T C 3: 104,365,251 (GRCm39) N634D probably benign Het
Mrc2 T A 11: 105,233,906 (GRCm39) probably null Het
Mroh3 A T 1: 136,118,550 (GRCm39) S558T possibly damaging Het
Ncapg2 G T 12: 116,398,281 (GRCm39) K627N possibly damaging Het
Ncstn A T 1: 171,899,095 (GRCm39) D345E probably damaging Het
Nkx1-1 G T 5: 33,591,223 (GRCm39) A33E unknown Het
Or2n1 T A 17: 38,486,905 (GRCm39) M310K probably benign Het
Osbpl9 G T 4: 108,991,025 (GRCm39) probably null Het
P2rx6 T C 16: 17,380,032 (GRCm39) V52A probably benign Het
Pcdhgb5 C T 18: 37,864,255 (GRCm39) L17F probably damaging Het
Pdk2 T C 11: 94,919,568 (GRCm39) I273V probably benign Het
Pdpr C T 8: 111,828,532 (GRCm39) Q12* probably null Het
Plxdc2 A G 2: 16,716,932 (GRCm39) T339A probably benign Het
Pramel27 G A 4: 143,579,828 (GRCm39) C471Y probably damaging Het
Retsat T C 6: 72,578,672 (GRCm39) V128A probably benign Het
Rnf17 A G 14: 56,697,432 (GRCm39) E442G probably damaging Het
Sec31b T C 19: 44,512,214 (GRCm39) N560S probably benign Het
Slc22a16 C T 10: 40,449,836 (GRCm39) Q91* probably null Het
Slc24a5 G T 2: 124,922,615 (GRCm39) A126S possibly damaging Het
Slc26a4 A T 12: 31,590,512 (GRCm39) D380E possibly damaging Het
Stc2 T A 11: 31,310,307 (GRCm39) D243V probably benign Het
Tshz2 G T 2: 169,727,965 (GRCm39) A385S probably damaging Het
Vmn1r113 G A 7: 20,521,903 (GRCm39) G232S probably benign Het
Vmn1r77 A G 7: 11,775,382 (GRCm39) T53A probably damaging Het
Zeb2 A T 2: 44,887,457 (GRCm39) Y518* probably null Het
Zfp760 T A 17: 21,941,991 (GRCm39) S389T possibly damaging Het
Other mutations in Or51f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01682:Or51f2 APN 7 102,526,440 (GRCm39) missense probably benign 0.02
IGL02349:Or51f2 APN 7 102,527,116 (GRCm39) missense probably benign 0.06
IGL02421:Or51f2 APN 7 102,526,966 (GRCm39) missense probably damaging 1.00
IGL03179:Or51f2 APN 7 102,527,279 (GRCm39) unclassified probably benign
FR4737:Or51f2 UTSW 7 102,526,440 (GRCm39) small insertion probably benign
R0003:Or51f2 UTSW 7 102,527,068 (GRCm39) missense probably benign 0.02
R0126:Or51f2 UTSW 7 102,526,347 (GRCm39) missense probably benign 0.25
R1435:Or51f2 UTSW 7 102,526,974 (GRCm39) missense probably damaging 1.00
R1585:Or51f2 UTSW 7 102,526,980 (GRCm39) missense probably benign 0.00
R1660:Or51f2 UTSW 7 102,526,863 (GRCm39) missense probably damaging 1.00
R1678:Or51f2 UTSW 7 102,526,870 (GRCm39) missense probably damaging 1.00
R2010:Or51f2 UTSW 7 102,526,892 (GRCm39) nonsense probably null
R4706:Or51f2 UTSW 7 102,526,640 (GRCm39) missense probably damaging 1.00
R5490:Or51f2 UTSW 7 102,527,100 (GRCm39) missense probably damaging 1.00
R5632:Or51f2 UTSW 7 102,527,004 (GRCm39) missense probably benign 0.00
R6370:Or51f2 UTSW 7 102,526,377 (GRCm39) missense probably benign 0.43
R7854:Or51f2 UTSW 7 102,526,992 (GRCm39) nonsense probably null
R8682:Or51f2 UTSW 7 102,526,646 (GRCm39) missense probably benign 0.02
R9650:Or51f2 UTSW 7 102,526,987 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCAAGAAGAGAAGCCTACATTTC -3'
(R):5'- AGCAGAACTCCGGATTCCATG -3'

Sequencing Primer
(F):5'- ATCTGATTGCCCTTCTTTTTCCAGAC -3'
(R):5'- CGGATTCCATGAAAGTAAACCCATGG -3'
Posted On 2018-07-23