Incidental Mutation 'R6675:Or2n1'
ID 527269
Institutional Source Beutler Lab
Gene Symbol Or2n1
Ensembl Gene ENSMUSG00000096009
Gene Name olfactory receptor family 2 subfamily N member 1
Synonyms GA_x6K02T2PSCP-2623613-2624551, MOR256-5, Olfr134
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R6675 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38485977-38486915 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38486905 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 310 (M310K)
Ref Sequence ENSEMBL: ENSMUSP00000151069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074883] [ENSMUST00000215900]
AlphaFold Q8VG95
Predicted Effect probably benign
Transcript: ENSMUST00000074883
AA Change: M310K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074423
Gene: ENSMUSG00000096009
AA Change: M310K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.4e-50 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215900
AA Change: M310K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,006,302 (GRCm39) T1268A probably benign Het
Adamts20 A G 15: 94,229,197 (GRCm39) probably null Het
Arhgap45 G T 10: 79,853,938 (GRCm39) D151Y probably null Het
Arhgef40 C A 14: 52,229,098 (GRCm39) L592I probably damaging Het
Ascc3 G T 10: 50,626,659 (GRCm39) E1720* probably null Het
Atp2c1 C T 9: 105,330,732 (GRCm39) probably null Het
Avpi1 G A 19: 42,112,183 (GRCm39) P125L probably benign Het
Cers3 A T 7: 66,435,844 (GRCm39) T232S possibly damaging Het
Cfap53 T C 18: 74,440,447 (GRCm39) probably null Het
Col4a3 T C 1: 82,646,646 (GRCm39) S386P unknown Het
Dhtkd1 A T 2: 5,908,889 (GRCm39) M735K probably damaging Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Gad2 T C 2: 22,563,997 (GRCm39) V400A possibly damaging Het
Gm10801 TC TCGCC 2: 98,494,151 (GRCm39) probably benign Het
Hmgxb3 T G 18: 61,270,648 (GRCm39) D892A possibly damaging Het
Hsd3b2 G A 3: 98,620,788 (GRCm39) T89I probably benign Het
Iars1 C A 13: 49,873,054 (GRCm39) A713D probably damaging Het
Itih1 G A 14: 30,651,798 (GRCm39) T848I possibly damaging Het
Kcne2 A G 16: 92,093,512 (GRCm39) D13G probably benign Het
Klra17 T A 6: 129,849,286 (GRCm39) N96I probably damaging Het
Lrig2 T C 3: 104,365,251 (GRCm39) N634D probably benign Het
Mrc2 T A 11: 105,233,906 (GRCm39) probably null Het
Mroh3 A T 1: 136,118,550 (GRCm39) S558T possibly damaging Het
Ncapg2 G T 12: 116,398,281 (GRCm39) K627N possibly damaging Het
Ncstn A T 1: 171,899,095 (GRCm39) D345E probably damaging Het
Nkx1-1 G T 5: 33,591,223 (GRCm39) A33E unknown Het
Or51f2 A G 7: 102,526,480 (GRCm39) E51G possibly damaging Het
Osbpl9 G T 4: 108,991,025 (GRCm39) probably null Het
P2rx6 T C 16: 17,380,032 (GRCm39) V52A probably benign Het
Pcdhgb5 C T 18: 37,864,255 (GRCm39) L17F probably damaging Het
Pdk2 T C 11: 94,919,568 (GRCm39) I273V probably benign Het
Pdpr C T 8: 111,828,532 (GRCm39) Q12* probably null Het
Plxdc2 A G 2: 16,716,932 (GRCm39) T339A probably benign Het
Pramel27 G A 4: 143,579,828 (GRCm39) C471Y probably damaging Het
Retsat T C 6: 72,578,672 (GRCm39) V128A probably benign Het
Rnf17 A G 14: 56,697,432 (GRCm39) E442G probably damaging Het
Sec31b T C 19: 44,512,214 (GRCm39) N560S probably benign Het
Slc22a16 C T 10: 40,449,836 (GRCm39) Q91* probably null Het
Slc24a5 G T 2: 124,922,615 (GRCm39) A126S possibly damaging Het
Slc26a4 A T 12: 31,590,512 (GRCm39) D380E possibly damaging Het
Stc2 T A 11: 31,310,307 (GRCm39) D243V probably benign Het
Tshz2 G T 2: 169,727,965 (GRCm39) A385S probably damaging Het
Vmn1r113 G A 7: 20,521,903 (GRCm39) G232S probably benign Het
Vmn1r77 A G 7: 11,775,382 (GRCm39) T53A probably damaging Het
Zeb2 A T 2: 44,887,457 (GRCm39) Y518* probably null Het
Zfp760 T A 17: 21,941,991 (GRCm39) S389T possibly damaging Het
Other mutations in Or2n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01677:Or2n1 APN 17 38,486,766 (GRCm39) missense probably damaging 1.00
IGL01749:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01750:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01751:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01753:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01757:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01765:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01766:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01767:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL01822:Or2n1 APN 17 38,486,339 (GRCm39) missense probably damaging 1.00
IGL02256:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02257:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02258:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02259:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02275:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02293:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02295:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02317:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
IGL02318:Or2n1 APN 17 38,486,577 (GRCm39) missense probably benign 0.04
R0230:Or2n1 UTSW 17 38,486,841 (GRCm39) missense probably damaging 1.00
R0363:Or2n1 UTSW 17 38,486,338 (GRCm39) missense probably damaging 1.00
R1074:Or2n1 UTSW 17 38,486,331 (GRCm39) missense probably damaging 1.00
R1506:Or2n1 UTSW 17 38,486,091 (GRCm39) missense probably benign
R2300:Or2n1 UTSW 17 38,486,441 (GRCm39) nonsense probably null
R3743:Or2n1 UTSW 17 38,486,793 (GRCm39) missense probably damaging 1.00
R3975:Or2n1 UTSW 17 38,486,386 (GRCm39) missense probably benign 0.03
R4230:Or2n1 UTSW 17 38,486,772 (GRCm39) missense possibly damaging 0.67
R5158:Or2n1 UTSW 17 38,486,345 (GRCm39) nonsense probably null
R5439:Or2n1 UTSW 17 38,486,917 (GRCm39) splice site probably null
R6144:Or2n1 UTSW 17 38,486,116 (GRCm39) missense probably damaging 1.00
R6309:Or2n1 UTSW 17 38,486,410 (GRCm39) missense probably benign 0.00
R6800:Or2n1 UTSW 17 38,486,013 (GRCm39) missense probably benign 0.01
R6873:Or2n1 UTSW 17 38,486,259 (GRCm39) missense probably benign
R7193:Or2n1 UTSW 17 38,485,987 (GRCm39) missense probably benign 0.44
R7534:Or2n1 UTSW 17 38,486,188 (GRCm39) missense probably benign 0.22
R7869:Or2n1 UTSW 17 38,486,830 (GRCm39) missense possibly damaging 0.94
R7912:Or2n1 UTSW 17 38,486,158 (GRCm39) missense probably damaging 0.99
R8048:Or2n1 UTSW 17 38,486,419 (GRCm39) missense probably benign 0.11
R8305:Or2n1 UTSW 17 38,486,464 (GRCm39) missense probably damaging 1.00
R9396:Or2n1 UTSW 17 38,486,421 (GRCm39) missense probably damaging 1.00
R9445:Or2n1 UTSW 17 38,486,694 (GRCm39) missense probably damaging 1.00
X0011:Or2n1 UTSW 17 38,486,742 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTCCAGCCATTAGTATGTATC -3'
(R):5'- TGGCAATTGCTTTGGAACAATG -3'

Sequencing Primer
(F):5'- GTCCAGCCATTAGTATGTATCTTCAG -3'
(R):5'- GTAAGGATTTCTGCATGTACAAGTAC -3'
Posted On 2018-07-23