Incidental Mutation 'R6679:Or5h26'
ID 527405
Institutional Source Beutler Lab
Gene Symbol Or5h26
Ensembl Gene ENSMUSG00000096695
Gene Name olfactory receptor family 5 subfamily H member 26
Synonyms MOR183-1, Olfr196, GA_x54KRFPKG5P-55389051-55388122
MMRRC Submission 044798-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R6679 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 58987010-58990817 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58988209 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 99 (I99T)
Ref Sequence ENSEMBL: ENSMUSP00000145684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077027] [ENSMUST00000205471]
AlphaFold E9PYP4
Predicted Effect probably benign
Transcript: ENSMUST00000077027
AA Change: I99T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000076285
Gene: ENSMUSG00000096695
AA Change: I99T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.1e-48 PFAM
Pfam:7tm_1 41 290 1.1e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205471
AA Change: I99T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 91% (40/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930449I24Rik T A 5: 146,441,750 (GRCm39) V299E probably damaging Het
Adgrb3 T C 1: 25,170,377 (GRCm39) I767V probably benign Het
Ahnak2 G A 12: 112,739,410 (GRCm39) T748I probably damaging Het
Aoc3 T A 11: 101,222,279 (GRCm39) L129M probably damaging Het
Arhgef7 T A 8: 11,874,667 (GRCm39) M540K possibly damaging Het
Bod1l T A 5: 41,974,009 (GRCm39) K2435M probably damaging Het
Col11a1 A G 3: 113,946,368 (GRCm39) probably null Het
Col5a3 C T 9: 20,690,329 (GRCm39) G1162R probably damaging Het
Creb5 G T 6: 53,662,454 (GRCm39) M250I possibly damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Homo
Dock10 A G 1: 80,544,514 (GRCm39) I557T probably benign Het
Efcab2 G A 1: 178,264,969 (GRCm39) A12T probably benign Het
Ehd1 A G 19: 6,344,474 (GRCm39) N245D probably benign Het
Erich3 T A 3: 154,468,066 (GRCm39) D839E possibly damaging Het
Fam13b T C 18: 34,620,075 (GRCm39) T270A possibly damaging Het
Fat2 A T 11: 55,200,131 (GRCm39) L981Q probably damaging Het
Fgfrl1 G A 5: 108,852,838 (GRCm39) W89* probably null Het
Fgfrl1 G T 5: 108,852,839 (GRCm39) W89C probably damaging Het
Gm10770 G A 2: 150,021,569 (GRCm39) P11S probably damaging Het
Gm10801 TC TCGGC 2: 98,494,151 (GRCm39) probably benign Het
Hdac3 A G 18: 38,077,986 (GRCm39) V190A possibly damaging Het
Htr1a A G 13: 105,581,936 (GRCm39) N392S probably damaging Het
Ift43 A G 12: 86,185,592 (GRCm39) M59V probably benign Het
Jakmip2 T C 18: 43,699,014 (GRCm39) T482A probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Nme8 A T 13: 19,875,140 (GRCm39) probably null Het
Peg10 CCAACAACAACAACAACAACAACA CCAACAACAACAACAACAACA 6: 4,754,276 (GRCm39) probably benign Het
Plec A G 15: 76,058,015 (GRCm39) F3996S probably damaging Het
Ppfia4 A T 1: 134,237,417 (GRCm39) Y961N probably damaging Het
Rag1 G A 2: 101,474,629 (GRCm39) P171L probably damaging Het
Rbm24 A T 13: 46,572,468 (GRCm39) probably benign Het
Rsf1 A AAGGCGACGG 7: 97,229,111 (GRCm39) probably null Het
Rxfp3 T C 15: 11,035,956 (GRCm39) Y472C probably damaging Het
Sash1 T A 10: 8,615,949 (GRCm39) I638F probably damaging Het
Sh3glb2 G A 2: 30,240,631 (GRCm39) R145W probably damaging Het
Ston2 G T 12: 91,614,870 (GRCm39) P513T probably damaging Het
Sycp2 A G 2: 178,022,721 (GRCm39) M470T probably damaging Het
Syt10 C A 15: 89,698,574 (GRCm39) D257Y probably damaging Het
Tcfl5 G T 2: 180,277,055 (GRCm39) L447I probably damaging Het
Tlr11 T C 14: 50,600,311 (GRCm39) W766R probably benign Het
Usp33 T A 3: 152,074,124 (GRCm39) D19E possibly damaging Het
Vmn1r123 T A 7: 20,896,868 (GRCm39) Y253* probably null Het
Wdr55 G A 18: 36,896,177 (GRCm39) G289D probably damaging Het
Zfp523 C T 17: 28,421,194 (GRCm39) T235M probably damaging Het
Other mutations in Or5h26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02560:Or5h26 APN 16 58,987,891 (GRCm39) nonsense probably null
PIT4495001:Or5h26 UTSW 16 58,988,337 (GRCm39) missense possibly damaging 0.48
R0312:Or5h26 UTSW 16 58,988,202 (GRCm39) missense probably benign 0.00
R0345:Or5h26 UTSW 16 58,988,269 (GRCm39) missense possibly damaging 0.90
R0644:Or5h26 UTSW 16 58,987,979 (GRCm39) missense probably damaging 1.00
R0679:Or5h26 UTSW 16 58,987,979 (GRCm39) missense probably damaging 1.00
R1709:Or5h26 UTSW 16 58,988,264 (GRCm39) missense probably benign 0.03
R1818:Or5h26 UTSW 16 58,988,243 (GRCm39) missense probably benign 0.00
R2090:Or5h26 UTSW 16 58,988,503 (GRCm39) start codon destroyed probably null 0.99
R5327:Or5h26 UTSW 16 58,987,983 (GRCm39) missense possibly damaging 0.96
R5945:Or5h26 UTSW 16 58,988,482 (GRCm39) missense probably benign 0.42
R6093:Or5h26 UTSW 16 58,988,330 (GRCm39) missense probably damaging 1.00
R6268:Or5h26 UTSW 16 58,987,656 (GRCm39) splice site probably null
R6487:Or5h26 UTSW 16 58,988,536 (GRCm39) splice site probably null
R6628:Or5h26 UTSW 16 58,988,344 (GRCm39) missense probably benign 0.00
R7642:Or5h26 UTSW 16 58,988,080 (GRCm39) missense probably benign 0.01
R8285:Or5h26 UTSW 16 58,988,176 (GRCm39) missense probably benign 0.35
R8336:Or5h26 UTSW 16 58,987,918 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- CTGAATACCTGAATTGAGCCAGAG -3'
(R):5'- GGCAACCTTGGTCTGATCAC -3'

Sequencing Primer
(F):5'- CAGGAAATCTTTAACAGTGGCATAAC -3'
(R):5'- GGTCTGATCACTCTCATCTGGAATG -3'
Posted On 2018-07-23