Incidental Mutation 'IGL01155:Naa16'
| ID |
52745 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Naa16
|
| Ensembl Gene |
ENSMUSG00000022020 |
| Gene Name |
N(alpha)-acetyltransferase 16, NatA auxiliary subunit |
| Synonyms |
Narg1l, 1300019C06Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
IGL01155
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
14 |
| Chromosomal Location |
79325269-79390778 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 79384715 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Asparagine
at position 27
(K27N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131268
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022597]
[ENSMUST00000163486]
[ENSMUST00000169500]
|
| AlphaFold |
Q9DBB4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000022597
AA Change: K61N
PolyPhen 2
Score 0.714 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: K61N
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
46 |
79 |
2.99e1 |
SMART |
|
TPR
|
80 |
113 |
2.98e-3 |
SMART |
|
Blast:TPR
|
224 |
257 |
1e-10 |
BLAST |
|
TPR
|
374 |
407 |
9.96e0 |
SMART |
|
TPR
|
408 |
441 |
7.47e0 |
SMART |
|
low complexity region
|
616 |
633 |
N/A |
INTRINSIC |
|
Blast:TPR
|
672 |
705 |
3e-12 |
BLAST |
|
low complexity region
|
830 |
841 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000163486
AA Change: K27N
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: K27N
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
12 |
45 |
2.99e1 |
SMART |
|
TPR
|
46 |
79 |
2.98e-3 |
SMART |
|
Blast:TPR
|
190 |
223 |
3e-10 |
BLAST |
|
TPR
|
340 |
373 |
9.96e0 |
SMART |
|
TPR
|
374 |
407 |
7.47e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165337
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169500
|
| SMART Domains |
Protein: ENSMUSP00000127298
Gene: ENSMUSG00000022020
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4KVO|D
|
1 |
46 |
1e-6 |
PDB |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,950,275 (GRCm38) |
V124I |
probably damaging |
Het |
| Adgrl3 |
T |
A |
5: 81,560,893 (GRCm38) |
I409N |
probably benign |
Het |
| Akap13 |
A |
G |
7: 75,569,936 (GRCm38) |
D29G |
probably damaging |
Het |
| Ap4e1 |
C |
A |
2: 127,043,445 (GRCm38) |
T322K |
probably damaging |
Het |
| Arfgef1 |
G |
A |
1: 10,198,982 (GRCm38) |
|
probably benign |
Het |
| Asic5 |
A |
G |
3: 82,008,588 (GRCm38) |
T282A |
probably benign |
Het |
| Bptf |
T |
C |
11: 107,080,727 (GRCm38) |
T985A |
probably damaging |
Het |
| Btnl9 |
A |
G |
11: 49,175,691 (GRCm38) |
F349L |
probably damaging |
Het |
| Bves |
T |
A |
10: 45,353,859 (GRCm38) |
I253K |
probably damaging |
Het |
| Cars |
T |
A |
7: 143,569,849 (GRCm38) |
Y455F |
probably benign |
Het |
| Cfap206 |
C |
T |
4: 34,721,562 (GRCm38) |
S162N |
probably damaging |
Het |
| Cuedc2 |
C |
A |
19: 46,332,649 (GRCm38) |
V15F |
probably damaging |
Het |
| Defa22 |
T |
A |
8: 21,163,037 (GRCm38) |
|
probably null |
Het |
| Fat1 |
G |
A |
8: 45,023,949 (GRCm38) |
A2011T |
probably damaging |
Het |
| Fyb2 |
C |
T |
4: 104,999,386 (GRCm38) |
T533I |
probably benign |
Het |
| Gm1043 |
T |
C |
5: 37,187,089 (GRCm38) |
L182P |
probably damaging |
Het |
| Ice1 |
A |
T |
13: 70,604,082 (GRCm38) |
V1295E |
possibly damaging |
Het |
| Il12b |
T |
A |
11: 44,404,088 (GRCm38) |
S18T |
probably benign |
Het |
| Iqcg |
A |
G |
16: 33,040,875 (GRCm38) |
V157A |
probably damaging |
Het |
| Itgax |
T |
A |
7: 128,145,035 (GRCm38) |
M937K |
probably benign |
Het |
| Large1 |
T |
C |
8: 73,131,989 (GRCm38) |
S84G |
probably benign |
Het |
| Lrp1b |
T |
C |
2: 41,770,935 (GRCm38) |
T54A |
probably benign |
Het |
| Mfn1 |
A |
G |
3: 32,542,836 (GRCm38) |
M148V |
probably damaging |
Het |
| Mobp |
C |
A |
9: 120,168,234 (GRCm38) |
T73K |
probably benign |
Het |
| Ms4a3 |
T |
C |
19: 11,629,655 (GRCm38) |
|
probably benign |
Het |
| Muc5ac |
C |
T |
7: 141,806,943 (GRCm38) |
|
probably benign |
Het |
| Mzt2 |
A |
C |
16: 15,862,410 (GRCm38) |
S104A |
possibly damaging |
Het |
| Nos1 |
T |
A |
5: 117,945,926 (GRCm38) |
I1267N |
probably damaging |
Het |
| Olfr16 |
T |
A |
1: 172,956,924 (GRCm38) |
I43N |
probably benign |
Het |
| Rara |
A |
G |
11: 98,968,184 (GRCm38) |
E153G |
possibly damaging |
Het |
| Scn2a |
T |
G |
2: 65,717,748 (GRCm38) |
S66A |
probably damaging |
Het |
| Slc6a1 |
A |
T |
6: 114,314,465 (GRCm38) |
|
probably null |
Het |
| Sorbs3 |
A |
G |
14: 70,199,341 (GRCm38) |
V136A |
probably damaging |
Het |
| Spink5 |
T |
A |
18: 43,981,147 (GRCm38) |
H143Q |
probably benign |
Het |
| Susd2 |
G |
A |
10: 75,640,892 (GRCm38) |
T99I |
possibly damaging |
Het |
| T |
C |
T |
17: 8,441,745 (GRCm38) |
|
probably null |
Het |
| Tac2 |
G |
A |
10: 127,726,134 (GRCm38) |
|
probably null |
Het |
| Tfap4 |
G |
T |
16: 4,547,359 (GRCm38) |
P180T |
probably damaging |
Het |
| Trap1 |
G |
A |
16: 4,043,978 (GRCm38) |
Q641* |
probably null |
Het |
| Unc119 |
A |
G |
11: 78,348,609 (GRCm38) |
N252S |
probably damaging |
Het |
|
| Other mutations in Naa16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00551:Naa16
|
APN |
14 |
79,355,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01025:Naa16
|
APN |
14 |
79,384,756 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01335:Naa16
|
APN |
14 |
79,345,116 (GRCm38) |
splice site |
probably benign |
|
|
IGL01981:Naa16
|
APN |
14 |
79,381,516 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL02230:Naa16
|
APN |
14 |
79,377,361 (GRCm38) |
splice site |
probably benign |
|
|
IGL02313:Naa16
|
APN |
14 |
79,384,668 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02418:Naa16
|
APN |
14 |
79,383,366 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02544:Naa16
|
APN |
14 |
79,335,820 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03051:Naa16
|
APN |
14 |
79,369,082 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL03064:Naa16
|
APN |
14 |
79,339,628 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03205:Naa16
|
APN |
14 |
79,356,512 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
PIT4508001:Naa16
|
UTSW |
14 |
79,369,087 (GRCm38) |
missense |
probably benign |
0.15 |
|
R0651:Naa16
|
UTSW |
14 |
79,351,392 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1429:Naa16
|
UTSW |
14 |
79,359,527 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1674:Naa16
|
UTSW |
14 |
79,387,057 (GRCm38) |
start codon destroyed |
probably null |
0.65 |
|
R1693:Naa16
|
UTSW |
14 |
79,351,456 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1874:Naa16
|
UTSW |
14 |
79,355,743 (GRCm38) |
missense |
possibly damaging |
0.62 |
|
R1992:Naa16
|
UTSW |
14 |
79,356,491 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2015:Naa16
|
UTSW |
14 |
79,345,059 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2391:Naa16
|
UTSW |
14 |
79,370,049 (GRCm38) |
missense |
probably benign |
0.16 |
|
R2847:Naa16
|
UTSW |
14 |
79,335,883 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2848:Naa16
|
UTSW |
14 |
79,335,883 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2877:Naa16
|
UTSW |
14 |
79,343,298 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3884:Naa16
|
UTSW |
14 |
79,343,262 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4001:Naa16
|
UTSW |
14 |
79,343,121 (GRCm38) |
splice site |
probably null |
|
|
R4199:Naa16
|
UTSW |
14 |
79,355,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4638:Naa16
|
UTSW |
14 |
79,340,033 (GRCm38) |
splice site |
probably null |
|
|
R4676:Naa16
|
UTSW |
14 |
79,336,348 (GRCm38) |
unclassified |
probably benign |
|
|
R4690:Naa16
|
UTSW |
14 |
79,345,057 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4952:Naa16
|
UTSW |
14 |
79,345,085 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5087:Naa16
|
UTSW |
14 |
79,377,415 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R5104:Naa16
|
UTSW |
14 |
79,384,700 (GRCm38) |
nonsense |
probably null |
|
|
R5729:Naa16
|
UTSW |
14 |
79,355,780 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6178:Naa16
|
UTSW |
14 |
79,383,340 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R6960:Naa16
|
UTSW |
14 |
79,359,471 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R7794:Naa16
|
UTSW |
14 |
79,377,494 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7936:Naa16
|
UTSW |
14 |
79,341,046 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R8356:Naa16
|
UTSW |
14 |
79,359,475 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8456:Naa16
|
UTSW |
14 |
79,359,475 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8892:Naa16
|
UTSW |
14 |
79,390,576 (GRCm38) |
missense |
probably benign |
0.32 |
|
R8931:Naa16
|
UTSW |
14 |
79,344,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9010:Naa16
|
UTSW |
14 |
79,370,042 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9068:Naa16
|
UTSW |
14 |
79,374,849 (GRCm38) |
missense |
probably benign |
0.18 |
|
R9360:Naa16
|
UTSW |
14 |
79,356,503 (GRCm38) |
missense |
probably benign |
0.05 |
|
R9688:Naa16
|
UTSW |
14 |
79,335,869 (GRCm38) |
nonsense |
probably null |
|
|
X0064:Naa16
|
UTSW |
14 |
79,351,389 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Naa16
|
UTSW |
14 |
79,344,979 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation