Incidental Mutation 'R6680:Adgre4'
ID 527472
Institutional Source Beutler Lab
Gene Symbol Adgre4
Ensembl Gene ENSMUSG00000032915
Gene Name adhesion G protein-coupled receptor E4
Synonyms EGF-TM7, Gpr127, FIRE, Emr4, D17Ertd479e
MMRRC Submission 044799-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6680 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 56056984-56160662 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 56098959 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 155 (K155R)
Ref Sequence ENSEMBL: ENSMUSP00000025004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025004]
AlphaFold Q91ZE5
Predicted Effect probably benign
Transcript: ENSMUST00000025004
AA Change: K155R

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000025004
Gene: ENSMUSG00000032915
AA Change: K155R

DomainStartEndE-ValueType
signal peptide 1 36 N/A INTRINSIC
Blast:EGF_like 38 76 2e-10 BLAST
Pfam:EGF_CA 77 117 3.6e-9 PFAM
GPS 288 338 4.03e-12 SMART
Pfam:7tm_2 343 588 5.7e-57 PFAM
low complexity region 613 628 N/A INTRINSIC
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 100% (35/35)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd31 T A 13: 96,967,117 (GRCm39) probably null Het
AW011738 A G 4: 156,288,182 (GRCm39) probably benign Het
Btnl12 T C 16: 37,676,536 (GRCm39) D77G probably benign Het
Ccl3 A G 11: 83,539,132 (GRCm39) S76P probably benign Het
Col5a3 C T 9: 20,690,329 (GRCm39) G1162R probably damaging Het
Dnaaf10 T C 11: 17,179,857 (GRCm39) L286P probably damaging Het
Fat2 G T 11: 55,201,684 (GRCm39) Y463* probably null Het
Frem3 A G 8: 81,395,949 (GRCm39) T1915A probably damaging Het
Hspg2 A G 4: 137,293,048 (GRCm39) Q4162R probably benign Het
Krt87 C T 15: 101,331,859 (GRCm39) R293H probably damaging Het
Mipep A G 14: 61,025,672 (GRCm39) I143V possibly damaging Het
Mrc2 C T 11: 105,216,579 (GRCm39) R123C probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Ndc80 T C 17: 71,824,540 (GRCm39) K223R probably null Het
Nudt16l2 A G 9: 105,020,773 (GRCm39) S163P probably damaging Het
Nuf2 A C 1: 169,342,578 (GRCm39) probably null Het
Omd T C 13: 49,743,004 (GRCm39) V18A possibly damaging Het
Or51a39 T A 7: 102,363,522 (GRCm39) I33F possibly damaging Het
Or8g21 T C 9: 38,905,954 (GRCm39) Y259C probably damaging Het
Or8k53 T A 2: 86,177,589 (GRCm39) I174F probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Shank2 A G 7: 143,974,603 (GRCm39) S1384G probably damaging Het
Slc22a28 A G 19: 8,078,757 (GRCm39) S311P probably benign Het
Sox6 C T 7: 115,076,218 (GRCm39) E765K possibly damaging Het
Tas2r106 A T 6: 131,655,437 (GRCm39) I138K probably damaging Het
Tbx15 T A 3: 99,220,389 (GRCm39) Y54* probably null Het
Tulp4 T G 17: 6,189,312 (GRCm39) W45G probably damaging Het
Ugt3a1 T C 15: 9,370,154 (GRCm39) Y433H probably damaging Het
Usp13 T C 3: 32,935,618 (GRCm39) V348A probably damaging Het
Vezf1 T C 11: 87,972,410 (GRCm39) I439T probably benign Het
Vmn2r93 C A 17: 18,536,920 (GRCm39) Y534* probably null Het
Zfp579 A G 7: 4,996,501 (GRCm39) L470P probably damaging Het
Zfp598 A G 17: 24,897,660 (GRCm39) N327S probably benign Het
Zscan4d A T 7: 10,896,366 (GRCm39) S335T possibly damaging Het
Other mutations in Adgre4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Adgre4 APN 17 56,098,915 (GRCm39) splice site probably benign
IGL00228:Adgre4 APN 17 56,109,135 (GRCm39) missense probably damaging 1.00
IGL00572:Adgre4 APN 17 56,127,648 (GRCm39) missense probably benign 0.00
IGL01404:Adgre4 APN 17 56,104,639 (GRCm39) missense possibly damaging 0.63
IGL01420:Adgre4 APN 17 56,106,785 (GRCm39) splice site probably benign
IGL01501:Adgre4 APN 17 56,109,002 (GRCm39) splice site probably benign
IGL01510:Adgre4 APN 17 56,125,760 (GRCm39) critical splice donor site probably null
IGL01554:Adgre4 APN 17 56,124,090 (GRCm39) missense probably damaging 1.00
IGL01607:Adgre4 APN 17 56,101,748 (GRCm39) splice site probably benign
IGL01767:Adgre4 APN 17 56,104,740 (GRCm39) missense probably benign 0.19
IGL02253:Adgre4 APN 17 56,067,573 (GRCm39) missense probably benign 0.01
IGL02358:Adgre4 APN 17 56,150,209 (GRCm39) missense probably benign 0.15
IGL02466:Adgre4 APN 17 56,121,188 (GRCm39) missense probably benign 0.42
IGL03057:Adgre4 APN 17 56,106,602 (GRCm39) splice site probably benign
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0070:Adgre4 UTSW 17 56,109,154 (GRCm39) missense probably damaging 0.98
R0111:Adgre4 UTSW 17 56,124,073 (GRCm39) missense possibly damaging 0.92
R0311:Adgre4 UTSW 17 56,109,010 (GRCm39) missense probably benign 0.36
R0366:Adgre4 UTSW 17 56,099,001 (GRCm39) nonsense probably null
R0415:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
R0465:Adgre4 UTSW 17 56,092,137 (GRCm39) splice site probably benign
R0619:Adgre4 UTSW 17 56,127,679 (GRCm39) missense possibly damaging 0.52
R0685:Adgre4 UTSW 17 56,099,035 (GRCm39) missense probably benign 0.05
R0724:Adgre4 UTSW 17 56,159,281 (GRCm39) missense probably benign 0.00
R0835:Adgre4 UTSW 17 56,106,637 (GRCm39) missense probably damaging 1.00
R1330:Adgre4 UTSW 17 56,085,814 (GRCm39) missense probably benign 0.36
R1452:Adgre4 UTSW 17 56,091,996 (GRCm39) missense probably benign 0.35
R1960:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R1961:Adgre4 UTSW 17 56,098,497 (GRCm39) missense probably benign
R2046:Adgre4 UTSW 17 56,085,847 (GRCm39) missense possibly damaging 0.82
R2421:Adgre4 UTSW 17 56,085,872 (GRCm39) missense probably benign 0.10
R2570:Adgre4 UTSW 17 56,085,878 (GRCm39) missense possibly damaging 0.54
R3162:Adgre4 UTSW 17 56,109,218 (GRCm39) splice site probably benign
R4222:Adgre4 UTSW 17 56,092,121 (GRCm39) missense probably damaging 1.00
R4526:Adgre4 UTSW 17 56,092,016 (GRCm39) nonsense probably null
R4631:Adgre4 UTSW 17 56,121,305 (GRCm39) missense probably null 1.00
R4689:Adgre4 UTSW 17 56,109,096 (GRCm39) missense probably damaging 1.00
R4701:Adgre4 UTSW 17 56,091,971 (GRCm39) missense probably damaging 1.00
R4792:Adgre4 UTSW 17 56,098,491 (GRCm39) missense probably benign 0.00
R5205:Adgre4 UTSW 17 56,101,727 (GRCm39) nonsense probably null
R5210:Adgre4 UTSW 17 56,092,029 (GRCm39) missense probably damaging 0.97
R5358:Adgre4 UTSW 17 56,125,758 (GRCm39) missense probably benign 0.00
R5873:Adgre4 UTSW 17 56,159,282 (GRCm39) missense probably benign 0.13
R6025:Adgre4 UTSW 17 56,099,013 (GRCm39) missense probably benign 0.00
R6257:Adgre4 UTSW 17 56,109,133 (GRCm39) missense possibly damaging 0.87
R6426:Adgre4 UTSW 17 56,109,196 (GRCm39) missense probably benign 0.18
R6440:Adgre4 UTSW 17 56,101,744 (GRCm39) critical splice donor site probably null
R6484:Adgre4 UTSW 17 56,109,036 (GRCm39) missense possibly damaging 0.52
R7086:Adgre4 UTSW 17 56,127,649 (GRCm39) missense probably benign 0.00
R7442:Adgre4 UTSW 17 56,159,340 (GRCm39) missense probably benign 0.04
R7467:Adgre4 UTSW 17 56,098,952 (GRCm39) missense probably benign 0.00
R7875:Adgre4 UTSW 17 56,099,016 (GRCm39) missense probably benign 0.00
R8007:Adgre4 UTSW 17 56,121,233 (GRCm39) missense probably damaging 0.99
R8096:Adgre4 UTSW 17 56,127,700 (GRCm39) missense probably damaging 1.00
R8172:Adgre4 UTSW 17 56,104,769 (GRCm39) missense probably benign 0.00
R8512:Adgre4 UTSW 17 56,125,760 (GRCm39) critical splice donor site probably null
R8972:Adgre4 UTSW 17 56,109,189 (GRCm39) missense probably damaging 1.00
R9018:Adgre4 UTSW 17 56,098,993 (GRCm39) missense probably benign 0.00
R9049:Adgre4 UTSW 17 56,092,094 (GRCm39) missense probably benign 0.05
S24628:Adgre4 UTSW 17 56,159,288 (GRCm39) missense probably benign 0.03
X0010:Adgre4 UTSW 17 56,121,308 (GRCm39) missense probably damaging 1.00
Z1177:Adgre4 UTSW 17 56,121,152 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- GCCTAGGGTATCTTCAGCTGTC -3'
(R):5'- TGCTCACCTATTCTGACATAGAGATG -3'

Sequencing Primer
(F):5'- GGGTATCTTCAGCTGTCATCAAAGAC -3'
(R):5'- CAGATTGCTATTCACATGAGATGTTC -3'
Posted On 2018-07-23