Incidental Mutation 'R6681:Olfr1450'
ID527519
Institutional Source Beutler Lab
Gene Symbol Olfr1450
Ensembl Gene ENSMUSG00000062892
Gene Nameolfactory receptor 1450
SynonymsMOR202-33, GA_x6K02T2RE5P-3283121-3284098
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #R6681 (G1)
Quality Score225.009
Status Validated
Chromosome19
Chromosomal Location12950258-12956406 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 12954459 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 290 (Y290C)
Ref Sequence ENSEMBL: ENSMUSP00000150243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082006] [ENSMUST00000213587] [ENSMUST00000213925]
Predicted Effect probably damaging
Transcript: ENSMUST00000082006
AA Change: Y290C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080666
Gene: ENSMUSG00000062892
AA Change: Y290C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.5e-6 PFAM
Pfam:7tm_1 41 290 2.1e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213587
AA Change: Y290C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213925
AA Change: Y290C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A T 3: 122,121,798 T971S probably damaging Het
Catsperb C T 12: 101,624,735 Q1021* probably null Het
Ccdc62 A G 5: 123,934,093 T62A probably benign Het
Cuzd1 A G 7: 131,311,683 S402P probably damaging Het
Dcun1d1 C T 3: 35,895,670 V244M probably damaging Het
Dennd2c A G 3: 103,131,661 T42A probably benign Het
Dnah7a T C 1: 53,521,226 probably null Het
Dnase1l1 C T X: 74,277,038 probably null Homo
Dpp4 A T 2: 62,348,549 F607L probably benign Het
Ech1 C T 7: 28,830,338 probably null Het
Fam53a A G 5: 33,607,840 L174P probably damaging Het
Fh1 T C 1: 175,619,124 D62G probably null Het
Gm15448 T A 7: 3,822,252 M464L probably benign Het
Gpatch11 T C 17: 78,840,099 I103T probably damaging Het
Hmgcll1 A T 9: 76,081,449 T169S probably benign Het
Kbtbd3 A T 9: 4,330,687 I354F probably benign Het
Kdm5b T C 1: 134,613,269 F700L possibly damaging Het
Mamdc4 C A 2: 25,567,744 G439V probably damaging Het
Mrps30 A T 13: 118,380,598 S362T probably damaging Het
Mug1 C T 6: 121,838,724 S29L possibly damaging Het
Myh2 G A 11: 67,178,348 D328N probably damaging Het
Olfr1106 T C 2: 87,048,598 T213A probably benign Het
Olfr1404 C A 1: 173,216,406 H252N probably damaging Het
Olfr969 T A 9: 39,795,414 I13N probably benign Het
Otx1 C A 11: 21,997,037 A91S probably damaging Het
Pus7l G A 15: 94,527,865 P552S probably benign Het
Rest A G 5: 77,280,997 K421R probably damaging Het
Rttn C A 18: 89,014,611 H668N probably damaging Het
Scn9a T C 2: 66,563,342 I228V possibly damaging Het
Scp2 G T 4: 108,091,316 Q155K probably damaging Het
Sec61a2 G A 2: 5,876,408 R18* probably null Het
Serpinb8 T A 1: 107,597,591 M41K probably damaging Het
Sgsm2 A T 11: 74,865,378 W382R probably damaging Het
Slc26a10 G T 10: 127,173,661 T606N possibly damaging Het
Slc30a6 T C 17: 74,404,032 I40T possibly damaging Het
Slfn5 G A 11: 82,956,378 E30K possibly damaging Het
Sorcs2 C A 5: 36,397,810 R79L probably benign Het
Tmc5 G A 7: 118,669,304 S865N probably damaging Het
Tmprss11c T A 5: 86,289,260 M1L possibly damaging Het
Trpv5 C G 6: 41,653,354 E601Q probably damaging Het
Ttc39b A T 4: 83,240,048 probably benign Het
Ttll6 T A 11: 96,138,863 C201S probably damaging Het
Vezt A G 10: 93,996,997 V204A probably benign Het
Vmn1r45 T A 6: 89,934,003 probably benign Het
Zfp433 A T 10: 81,720,888 H408L probably damaging Het
Zfp865 T C 7: 5,029,451 I145T possibly damaging Het
Other mutations in Olfr1450
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01978:Olfr1450 APN 19 12954042 missense probably benign 0.00
IGL02378:Olfr1450 APN 19 12954383 missense probably benign 0.01
IGL02405:Olfr1450 APN 19 12954459 missense probably damaging 1.00
IGL02493:Olfr1450 APN 19 12953774 missense probably benign 0.12
IGL02496:Olfr1450 APN 19 12954192 missense possibly damaging 0.86
IGL02866:Olfr1450 APN 19 12954355 missense possibly damaging 0.81
IGL02886:Olfr1450 APN 19 12954518 missense probably benign 0.00
IGL03223:Olfr1450 APN 19 12953904 missense probably benign 0.00
IGL03286:Olfr1450 APN 19 12954168 missense probably benign 0.05
IGL03396:Olfr1450 APN 19 12953820 missense probably damaging 1.00
R0106:Olfr1450 UTSW 19 12954356 missense probably benign 0.10
R0106:Olfr1450 UTSW 19 12954356 missense probably benign 0.10
R0544:Olfr1450 UTSW 19 12953702 missense possibly damaging 0.79
R1660:Olfr1450 UTSW 19 12953691 missense probably damaging 1.00
R2020:Olfr1450 UTSW 19 12954332 missense possibly damaging 0.61
R4292:Olfr1450 UTSW 19 12954156 missense possibly damaging 0.83
R4647:Olfr1450 UTSW 19 12954077 missense probably benign 0.00
R5964:Olfr1450 UTSW 19 12954531 missense probably benign 0.03
R6398:Olfr1450 UTSW 19 12954317 missense probably damaging 1.00
R7129:Olfr1450 UTSW 19 12954114 missense possibly damaging 0.94
R7399:Olfr1450 UTSW 19 12954447 missense probably damaging 1.00
R7561:Olfr1450 UTSW 19 12954039 missense probably benign 0.00
R7692:Olfr1450 UTSW 19 12953642 missense possibly damaging 0.59
R8094:Olfr1450 UTSW 19 12954002 missense probably benign 0.00
R8258:Olfr1450 UTSW 19 12954363 missense possibly damaging 0.58
R8259:Olfr1450 UTSW 19 12954363 missense possibly damaging 0.58
Predicted Primers PCR Primer
(F):5'- GAAGAAGGCCTCCTCTACTTG -3'
(R):5'- ACCATGATTGAGCCCTGATG -3'

Sequencing Primer
(F):5'- AAGGCCTCCTCTACTTGTGCATC -3'
(R):5'- TGATTGAGCCCTGATGCAAAC -3'
Posted On2018-07-23