Incidental Mutation 'R6682:Tmem179'
ID527549
Institutional Source Beutler Lab
Gene Symbol Tmem179
Ensembl Gene ENSMUSG00000054013
Gene Nametransmembrane protein 179
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #R6682 (G1)
Quality Score225.009
Status Not validated
Chromosome12
Chromosomal Location112500189-112516747 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 112503280 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Asparagine at position 29 (D29N)
Ref Sequence ENSEMBL: ENSMUSP00000152792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057465] [ENSMUST00000066791] [ENSMUST00000222836] [ENSMUST00000223266]
Predicted Effect probably benign
Transcript: ENSMUST00000057465
SMART Domains Protein: ENSMUSP00000056220
Gene: ENSMUSG00000043122

DomainStartEndE-ValueType
Pfam:DUF4658 32 165 4e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000066791
AA Change: D162N

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000068004
Gene: ENSMUSG00000054013
AA Change: D162N

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
transmembrane domain 73 95 N/A INTRINSIC
transmembrane domain 102 124 N/A INTRINSIC
transmembrane domain 171 193 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000222836
AA Change: D29N

PolyPhen 2 Score 0.247 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000223266
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aspm T C 1: 139,457,722 V368A possibly damaging Het
Bcl9l A G 9: 44,501,103 T92A possibly damaging Het
Celsr2 A T 3: 108,400,501 probably null Het
Cndp2 T C 18: 84,677,330 K149E probably benign Het
Cnpy4 T C 5: 138,187,722 probably null Het
Cox6c A T 15: 35,938,173 probably null Het
Cpt2 G T 4: 107,904,430 S158R probably damaging Het
Dlgap1 A G 17: 70,787,123 K813R probably damaging Het
Dock10 A C 1: 80,512,621 L1927R probably damaging Het
Gak T A 5: 108,598,876 K430I probably damaging Het
Grik3 T A 4: 125,650,466 Y327N probably damaging Het
Ldb3 T A 14: 34,552,264 T334S possibly damaging Het
Ldlr A G 9: 21,732,375 D85G probably benign Het
Med26 T A 8: 72,496,083 T391S probably benign Het
Mmp27 A G 9: 7,573,605 T233A probably benign Het
Mob1a A G 6: 83,334,150 Y117C possibly damaging Het
Mrps35 A T 6: 147,048,279 E97V possibly damaging Het
Msln A T 17: 25,753,019 S75T probably damaging Het
Myoz1 C T 14: 20,653,619 probably null Het
Nim1k A G 13: 119,712,188 I390T probably benign Het
Olfr1301 C T 2: 111,754,635 P129S probably damaging Het
Olfr370 A G 8: 83,541,558 H138R probably benign Het
Pclo A C 5: 14,539,879 Q731P unknown Het
Prl3d3 G A 13: 27,161,040 E132K probably benign Het
Pth1r C T 9: 110,727,251 probably null Het
Ptpru T C 4: 131,820,782 M135V probably benign Het
Slc12a9 A T 5: 137,327,401 L316Q probably damaging Het
Slc35f6 G A 5: 30,657,420 M177I possibly damaging Het
Smc4 T A 3: 69,007,241 S62R probably damaging Het
Togaram2 A T 17: 71,704,754 D476V probably benign Het
Trpc4ap C T 2: 155,637,767 probably null Het
Trpm8 C A 1: 88,326,502 T149K probably damaging Het
Uhmk1 C T 1: 170,212,235 probably null Het
Vmn2r79 C A 7: 87,004,162 T545K possibly damaging Het
Vmn2r95 C A 17: 18,440,227 N300K probably damaging Het
Wdr41 G A 13: 95,013,131 G419D probably damaging Het
Zc3hav1 A T 6: 38,325,195 H597Q probably benign Het
Zfp704 T C 3: 9,565,193 E36G probably benign Het
Zfp9 A G 6: 118,467,241 V47A possibly damaging Het
Other mutations in Tmem179
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1470:Tmem179 UTSW 12 112501854 missense probably benign 0.05
R1470:Tmem179 UTSW 12 112501854 missense probably benign 0.05
R1553:Tmem179 UTSW 12 112504660 missense probably benign
R2405:Tmem179 UTSW 12 112501913 missense probably damaging 1.00
R4125:Tmem179 UTSW 12 112511027 missense possibly damaging 0.71
R4128:Tmem179 UTSW 12 112511027 missense possibly damaging 0.71
R4480:Tmem179 UTSW 12 112503303 missense probably benign
R4916:Tmem179 UTSW 12 112501834 missense probably damaging 1.00
R7636:Tmem179 UTSW 12 112510743 critical splice donor site probably null
Predicted Primers
Posted On2018-07-23