Incidental Mutation 'R6687:Dennd3'
ID 527844
Institutional Source Beutler Lab
Gene Symbol Dennd3
Ensembl Gene ENSMUSG00000036661
Gene Name DENN domain containing 3
Synonyms E030003N15Rik
MMRRC Submission 044805-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R6687 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 73384409-73444091 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 73428215 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 854 (V854M)
Ref Sequence ENSEMBL: ENSMUSP00000134002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043414] [ENSMUST00000160267] [ENSMUST00000173292]
AlphaFold A2RT67
Predicted Effect possibly damaging
Transcript: ENSMUST00000043414
AA Change: V854M

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000046774
Gene: ENSMUSG00000036661
AA Change: V854M

DomainStartEndE-ValueType
Blast:uDENN 12 161 3e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
WD40 1232 1272 1.1e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000160267
SMART Domains Protein: ENSMUSP00000124538
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
Blast:WD40 51 90 2e-9 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162488
SMART Domains Protein: ENSMUSP00000125657
Gene: ENSMUSG00000036661

DomainStartEndE-ValueType
low complexity region 5 19 N/A INTRINSIC
Blast:DENN 33 104 5e-28 BLAST
DENN 116 302 1.54e-62 SMART
dDENN 312 376 5.63e-6 SMART
WD40 892 931 3.68e1 SMART
WD40 934 975 3.32e-5 SMART
WD40 1109 1149 1.1e1 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000173292
AA Change: V854M

PolyPhen 2 Score 0.640 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000134002
Gene: ENSMUSG00000036661
AA Change: V854M

DomainStartEndE-ValueType
Blast:uDENN 12 161 2e-78 BLAST
DENN 187 373 1.54e-62 SMART
dDENN 436 499 6.81e-14 SMART
WD40 1015 1054 3.68e1 SMART
WD40 1057 1098 3.32e-5 SMART
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 T C 3: 151,248,392 (GRCm39) V688A probably benign Het
AI661453 A G 17: 47,777,927 (GRCm39) probably benign Het
Atp6ap1l A G 13: 91,034,842 (GRCm39) F180S probably benign Het
Cfd G A 10: 79,727,553 (GRCm39) V77M probably damaging Het
Col5a2 A T 1: 45,422,764 (GRCm39) L1151H probably damaging Het
Dlg5 C T 14: 24,240,441 (GRCm39) R247Q probably damaging Het
Fam3c G C 6: 22,328,669 (GRCm39) P53A probably benign Het
Gpbp1 T C 13: 111,574,619 (GRCm39) N302D possibly damaging Het
Hmcn1 A G 1: 150,620,784 (GRCm39) V1142A probably benign Het
Ighv9-3 G A 12: 114,104,544 (GRCm39) S40F probably damaging Het
Insr C T 8: 3,248,111 (GRCm39) R478H probably benign Het
Kcna2 C A 3: 107,012,343 (GRCm39) S308Y probably damaging Het
Larp1 A G 11: 57,948,156 (GRCm39) D985G probably damaging Het
Loxl3 A T 6: 83,027,645 (GRCm39) H729L probably damaging Het
Lrrc14b T C 13: 74,508,881 (GRCm39) M509V probably benign Het
Lrrc8e A G 8: 4,284,798 (GRCm39) Y341C probably damaging Het
Mettl18 A G 1: 163,824,369 (GRCm39) D230G possibly damaging Het
Mup12 T C 4: 60,697,308 (GRCm39) probably benign Het
Myo1c T C 11: 75,563,027 (GRCm39) S1020P probably benign Het
Or3a4 C A 11: 73,945,210 (GRCm39) R125L probably damaging Het
Phkb T C 8: 86,756,175 (GRCm39) I823T probably damaging Het
Psmb5 C A 14: 54,854,130 (GRCm39) R116L probably damaging Het
Rpap2 T C 5: 107,751,496 (GRCm39) probably null Het
Rpl38 T C 11: 114,559,594 (GRCm39) probably benign Het
Scn8a T C 15: 100,872,508 (GRCm39) F516L probably benign Het
Slc51a A T 16: 32,298,543 (GRCm39) D71E probably damaging Het
Slco1a6 T C 6: 142,045,076 (GRCm39) E470G possibly damaging Het
Spag17 C A 3: 100,000,266 (GRCm39) H1811N probably benign Het
Sycp2 C T 2: 177,996,753 (GRCm39) C1150Y probably damaging Het
Ttc12 A G 9: 49,349,718 (GRCm39) V693A probably benign Het
Wdr83 C T 8: 85,806,778 (GRCm39) V101I probably benign Het
Wnt3 G T 11: 103,703,411 (GRCm39) R298L probably damaging Het
Other mutations in Dennd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Dennd3 APN 15 73,438,982 (GRCm39) missense probably benign 0.26
IGL00579:Dennd3 APN 15 73,412,691 (GRCm39) missense possibly damaging 0.63
IGL02101:Dennd3 APN 15 73,399,794 (GRCm39) missense possibly damaging 0.81
IGL02164:Dennd3 APN 15 73,416,297 (GRCm39) missense probably benign 0.26
IGL02389:Dennd3 APN 15 73,438,905 (GRCm39) missense probably damaging 1.00
IGL02604:Dennd3 APN 15 73,428,252 (GRCm39) missense probably damaging 1.00
IGL02697:Dennd3 APN 15 73,396,085 (GRCm39) missense possibly damaging 0.82
IGL02885:Dennd3 APN 15 73,440,545 (GRCm39) missense probably benign
IGL03356:Dennd3 APN 15 73,440,482 (GRCm39) missense probably benign 0.19
IGL03388:Dennd3 APN 15 73,416,208 (GRCm39) missense probably damaging 0.98
BB006:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
BB016:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R0118:Dennd3 UTSW 15 73,436,925 (GRCm39) missense probably damaging 1.00
R0925:Dennd3 UTSW 15 73,405,284 (GRCm39) missense probably damaging 1.00
R1076:Dennd3 UTSW 15 73,412,582 (GRCm39) missense probably damaging 1.00
R1355:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1370:Dennd3 UTSW 15 73,412,703 (GRCm39) splice site probably benign
R1480:Dennd3 UTSW 15 73,404,695 (GRCm39) missense probably benign 0.20
R1727:Dennd3 UTSW 15 73,436,977 (GRCm39) missense possibly damaging 0.95
R1732:Dennd3 UTSW 15 73,409,267 (GRCm39) splice site probably benign
R1771:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1776:Dennd3 UTSW 15 73,426,950 (GRCm39) missense possibly damaging 0.71
R1779:Dennd3 UTSW 15 73,394,357 (GRCm39) critical splice donor site probably null
R1838:Dennd3 UTSW 15 73,436,949 (GRCm39) missense probably damaging 1.00
R2146:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2146:Dennd3 UTSW 15 73,395,345 (GRCm39) missense probably damaging 1.00
R2147:Dennd3 UTSW 15 73,395,336 (GRCm39) missense probably damaging 1.00
R2148:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2149:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2150:Dennd3 UTSW 15 73,426,909 (GRCm39) missense probably benign 0.35
R2174:Dennd3 UTSW 15 73,427,154 (GRCm39) missense probably damaging 1.00
R2295:Dennd3 UTSW 15 73,395,404 (GRCm39) critical splice donor site probably null
R2905:Dennd3 UTSW 15 73,429,495 (GRCm39) missense probably damaging 1.00
R3106:Dennd3 UTSW 15 73,436,973 (GRCm39) nonsense probably null
R3757:Dennd3 UTSW 15 73,394,083 (GRCm39) missense probably benign 0.00
R3785:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3786:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3787:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R3847:Dennd3 UTSW 15 73,414,581 (GRCm39) missense possibly damaging 0.64
R4369:Dennd3 UTSW 15 73,412,658 (GRCm39) missense probably damaging 0.98
R4601:Dennd3 UTSW 15 73,439,009 (GRCm39) missense probably damaging 0.99
R4666:Dennd3 UTSW 15 73,442,709 (GRCm39) missense probably damaging 1.00
R4680:Dennd3 UTSW 15 73,405,225 (GRCm39) missense possibly damaging 0.82
R4708:Dennd3 UTSW 15 73,395,344 (GRCm39) missense probably damaging 1.00
R4789:Dennd3 UTSW 15 73,394,131 (GRCm39) missense probably damaging 1.00
R4920:Dennd3 UTSW 15 73,412,574 (GRCm39) missense probably benign 0.13
R5043:Dennd3 UTSW 15 73,399,785 (GRCm39) missense probably benign 0.00
R5074:Dennd3 UTSW 15 73,419,144 (GRCm39) missense probably damaging 1.00
R5410:Dennd3 UTSW 15 73,419,297 (GRCm39) missense probably benign 0.02
R5421:Dennd3 UTSW 15 73,438,964 (GRCm39) missense probably benign
R5560:Dennd3 UTSW 15 73,404,744 (GRCm39) missense probably damaging 1.00
R6008:Dennd3 UTSW 15 73,438,929 (GRCm39) missense possibly damaging 0.88
R6357:Dennd3 UTSW 15 73,428,321 (GRCm39) missense possibly damaging 0.49
R6563:Dennd3 UTSW 15 73,416,229 (GRCm39) missense probably damaging 0.98
R6837:Dennd3 UTSW 15 73,429,542 (GRCm39) missense probably damaging 1.00
R6910:Dennd3 UTSW 15 73,426,965 (GRCm39) missense probably benign 0.01
R7125:Dennd3 UTSW 15 73,405,140 (GRCm39) missense possibly damaging 0.50
R7297:Dennd3 UTSW 15 73,429,459 (GRCm39) missense probably damaging 1.00
R7524:Dennd3 UTSW 15 73,396,095 (GRCm39) nonsense probably null
R7580:Dennd3 UTSW 15 73,428,296 (GRCm39) missense possibly damaging 0.89
R7653:Dennd3 UTSW 15 73,434,275 (GRCm39) missense probably damaging 0.99
R7731:Dennd3 UTSW 15 73,434,216 (GRCm39) missense probably damaging 0.99
R7767:Dennd3 UTSW 15 73,394,079 (GRCm39) missense probably benign
R7806:Dennd3 UTSW 15 73,442,624 (GRCm39) missense possibly damaging 0.87
R7860:Dennd3 UTSW 15 73,412,657 (GRCm39) missense probably damaging 0.97
R7902:Dennd3 UTSW 15 73,439,964 (GRCm39) critical splice donor site probably benign
R7929:Dennd3 UTSW 15 73,436,423 (GRCm39) missense probably damaging 1.00
R8218:Dennd3 UTSW 15 73,384,622 (GRCm39) missense probably benign 0.31
R8436:Dennd3 UTSW 15 73,434,198 (GRCm39) missense probably damaging 1.00
R8444:Dennd3 UTSW 15 73,442,672 (GRCm39) missense probably benign 0.09
R8698:Dennd3 UTSW 15 73,394,154 (GRCm39) missense possibly damaging 0.52
R8967:Dennd3 UTSW 15 73,419,426 (GRCm39) missense possibly damaging 0.89
R9147:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9148:Dennd3 UTSW 15 73,429,463 (GRCm39) missense probably damaging 1.00
R9194:Dennd3 UTSW 15 73,419,153 (GRCm39) missense probably benign 0.04
R9449:Dennd3 UTSW 15 73,429,477 (GRCm39) missense probably damaging 1.00
R9501:Dennd3 UTSW 15 73,419,041 (GRCm39) missense probably benign 0.01
R9616:Dennd3 UTSW 15 73,440,563 (GRCm39) missense probably benign
R9730:Dennd3 UTSW 15 73,426,959 (GRCm39) missense probably damaging 1.00
RF006:Dennd3 UTSW 15 73,419,441 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTAGTCCCTGCCTGACTTG -3'
(R):5'- CTTCCAAGTGCTGCAAGCTC -3'

Sequencing Primer
(F):5'- TGCCTGACTTGCCAGCTG -3'
(R):5'- CAAGTGCTGCAAGCTCTGGATG -3'
Posted On 2018-07-23