Mutagenetix > Incidental Mutation

Incidental Mutation 'R6692:Vmn1r231'

527930

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r231

Ensembl Gene

ENSMUSG00000050933

Gene Name

vomeronasal 1 receptor 231

Synonyms

V1re7

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

R6692 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20889716-20890651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20890483 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 57 (I57V)

Ref Sequence

ENSEMBL: ENSMUSP00000056228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061278]

AlphaFold

Q8R2A3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000061278
AA Change: I57V

PolyPhen 2 Score 0.461 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: I57V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	6	294	1.6e-13	PFAM
Pfam:V1R	36	297	1.6e-27	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232004

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.1%

Validation Efficiency

100% (38/38)

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahcyl1	C	T	3: 107,675,085	G54D	probably damaging	Het
Aldh1b1	T	C	4: 45,803,427	C322R	probably damaging	Het
Cdc14b	T	C	13: 64,215,563	I258V	probably damaging	Het
Cenph	T	C	13: 100,772,735	I55V	probably benign	Het
Cep290	T	A	10: 100,569,144		probably null	Het
Ces2b	A	G	8: 104,837,287	Y431C	probably damaging	Het
Cyp4f17	T	C	17: 32,506,976	S28P	possibly damaging	Het
Cyp4f40	C	G	17: 32,675,742	T427S	possibly damaging	Het
Exoc2	A	G	13: 30,935,507	I137T	probably benign	Het
Fam168b	C	A	1: 34,836,741	G21V	probably damaging	Het
G3bp1	T	A	11: 55,493,509	D168E	probably benign	Het
Gm765	T	G	6: 98,248,208	H38P	possibly damaging	Het
Impg2	T	A	16: 56,252,333	L376H	probably damaging	Het
Kdm4d	A	T	9: 14,463,065	M499K	probably benign	Het
Lonp1	C	T	17: 56,619,230	V426M	probably damaging	Het
Lypla2	C	A	4: 135,970,862	A26S	probably benign	Het
Map3k13	T	C	16: 21,905,237	V323A	possibly damaging	Het
Mov10	A	G	3: 104,818,044	L83P	probably damaging	Het
Mphosph9	G	T	5: 124,260,116	A1039D	probably damaging	Het
Nedd1	T	C	10: 92,698,337	K317R	possibly damaging	Het
Olfr1117-ps1	A	G	2: 87,308,992	T68A	possibly damaging	Het
Pde3a	T	A	6: 141,479,346	S623T	probably damaging	Het
Pld1	T	A	3: 28,041,199	M227K	probably benign	Het
Rell1	T	G	5: 63,937,867	K85N	probably damaging	Het
Rhbdf1	T	C	11: 32,215,652	T93A	probably damaging	Het
Sccpdh	T	A	1: 179,684,227	M88K	possibly damaging	Het
Siae	T	G	9: 37,642,799		probably null	Het
Slc22a16	G	A	10: 40,603,905	E637K	unknown	Het
Stk19	C	T	17: 34,824,794	G95S	probably benign	Het
Stpg2	G	A	3: 139,522,977		probably null	Het
Sult2a5	T	A	7: 13,624,132	F30I	probably damaging	Het
Svil	A	G	18: 5,082,853	E748G	probably damaging	Het
Swap70	T	A	7: 110,269,919	H306Q	probably benign	Het
Try10	G	A	6: 41,357,821	G227D	probably damaging	Het
Ttn	T	C	2: 76,896,369		probably benign	Het
Ttn	T	A	2: 76,919,092	H3871L	probably benign	Het
Vpreb1	A	G	16: 16,868,802	S75P	probably damaging	Het
Zkscan5	A	G	5: 145,221,084		probably null	Het

Other mutations in Vmn1r231

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Vmn1r231	APN	17	20890566	missense	possibly damaging	0.68
IGL02124:Vmn1r231	APN	17	20890306	missense	probably damaging	1.00
IGL02151:Vmn1r231	APN	17	20889735	missense	probably benign	0.06
R0066:Vmn1r231	UTSW	17	20889736	missense	probably benign	0.27
R0066:Vmn1r231	UTSW	17	20889736	missense	probably benign	0.27
R0396:Vmn1r231	UTSW	17	20890399	missense	probably damaging	0.98
R0427:Vmn1r231	UTSW	17	20890228	missense	probably benign	0.05
R0470:Vmn1r231	UTSW	17	20890003	nonsense	probably null
R0848:Vmn1r231	UTSW	17	20890171	missense	probably damaging	1.00
R1692:Vmn1r231	UTSW	17	20890609	missense	probably benign	0.02
R1987:Vmn1r231	UTSW	17	20889950	missense	probably damaging	1.00
R1988:Vmn1r231	UTSW	17	20889950	missense	probably damaging	1.00
R2105:Vmn1r231	UTSW	17	20890118	missense	possibly damaging	0.66
R4440:Vmn1r231	UTSW	17	20890456	missense	possibly damaging	0.48
R4634:Vmn1r231	UTSW	17	20890398	missense	possibly damaging	0.46
R4646:Vmn1r231	UTSW	17	20890309	missense	probably damaging	1.00
R4678:Vmn1r231	UTSW	17	20890227	missense	possibly damaging	0.94
R4696:Vmn1r231	UTSW	17	20890639	missense	possibly damaging	0.63
R4938:Vmn1r231	UTSW	17	20890351	missense	possibly damaging	0.76
R5544:Vmn1r231	UTSW	17	20890578	missense	probably damaging	1.00
R5942:Vmn1r231	UTSW	17	20890155	missense	possibly damaging	0.83
R6053:Vmn1r231	UTSW	17	20889819	missense	probably damaging	1.00
R6712:Vmn1r231	UTSW	17	20889730	missense	possibly damaging	0.54
R7131:Vmn1r231	UTSW	17	20889878	missense	possibly damaging	0.87
R7854:Vmn1r231	UTSW	17	20890632	missense	probably damaging	0.98
R7918:Vmn1r231	UTSW	17	20889974	nonsense	probably null
R8187:Vmn1r231	UTSW	17	20890631	missense	probably benign	0.10
R8238:Vmn1r231	UTSW	17	20890378	missense	probably benign	0.08
R8313:Vmn1r231	UTSW	17	20890027	missense	probably benign	0.02
R8525:Vmn1r231	UTSW	17	20889739	missense	probably benign	0.06
R9276:Vmn1r231	UTSW	17	20890298	missense	probably benign	0.00
RF010:Vmn1r231	UTSW	17	20889993	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ATGGCCTGGAAGACACTCAAG -3'
(R):5'- TCCACTGCCTAATGGTAAAACATC -3'

Sequencing Primer
(F):5'- CACTCAAGAGACAGATGGTACCAATG -3'
(R):5'- ACATCATTTTGGTCAGAGAAGTG -3'

Posted On

2018-07-23