Incidental Mutation 'R6298:Or6k2'
ID 527935
Institutional Source Beutler Lab
Gene Symbol Or6k2
Ensembl Gene ENSMUSG00000055033
Gene Name olfactory receptor family 6 subfamily K member 2
Synonyms GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
MMRRC Submission 044408-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R6298 (G1)
Quality Score 147.008
Status Validated
Chromosome 1
Chromosomal Location 173986288-173987333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173979748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 222 (V222D)
Ref Sequence ENSEMBL: ENSMUSP00000136689 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179386] [ENSMUST00000213748]
AlphaFold E9Q4G0
Predicted Effect probably benign
Transcript: ENSMUST00000179386
AA Change: V222D

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000136689
Gene: ENSMUSG00000091950
AA Change: V222D

DomainStartEndE-ValueType
low complexity region 25 38 N/A INTRINSIC
Pfam:7tm_1 41 288 5.6e-29 PFAM
Pfam:7tm_4 139 285 4.7e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213748
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency 98% (79/81)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abtb2 A T 2: 103,539,833 (GRCm39) M733L probably benign Het
Acss3 G A 10: 106,920,717 (GRCm39) P131L probably damaging Het
Adgrv1 T A 13: 81,539,886 (GRCm39) I5678F probably benign Het
Aff1 C T 5: 103,902,586 (GRCm39) L6F possibly damaging Het
Ank3 G T 10: 69,686,006 (GRCm39) R273L probably damaging Het
Anks1b G A 10: 90,516,699 (GRCm39) G898D probably damaging Het
Anxa11 C T 14: 25,873,158 (GRCm39) P131S unknown Het
Ap4e1 T A 2: 126,889,035 (GRCm39) M500K probably benign Het
Bag3 T C 7: 128,141,922 (GRCm39) S138P probably damaging Het
Capn9 T C 8: 125,344,193 (GRCm39) V670A probably benign Het
Ccne2 T A 4: 11,199,306 (GRCm39) W236R probably damaging Het
Cdh23 A T 10: 60,262,451 (GRCm39) Y702* probably null Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Cit A T 5: 116,086,124 (GRCm39) E896V probably damaging Het
Cntln T A 4: 85,014,998 (GRCm39) N1096K probably damaging Het
Cntnap5c T C 17: 58,411,747 (GRCm39) C544R probably damaging Het
Csf1 A T 3: 107,655,675 (GRCm39) L452Q possibly damaging Het
Cts8 T A 13: 61,397,037 (GRCm39) K294N possibly damaging Het
Dcakd T G 11: 102,890,618 (GRCm39) E56D possibly damaging Het
Dnah17 T C 11: 117,998,987 (GRCm39) I929V probably benign Het
Dnah2 G T 11: 69,382,467 (GRCm39) H1214Q probably benign Het
Dock9 T C 14: 121,872,006 (GRCm39) D536G probably damaging Het
Drc3 A G 11: 60,284,596 (GRCm39) N467S possibly damaging Het
Dysf A G 6: 84,084,118 (GRCm39) probably null Het
Ecpas T G 4: 58,877,157 (GRCm39) T93P probably damaging Het
Evpl A T 11: 116,121,748 (GRCm39) L378Q probably damaging Het
Fer1l4 A T 2: 155,866,660 (GRCm39) H1520Q probably damaging Het
Fhod1 A T 8: 106,063,780 (GRCm39) probably benign Het
Gabra1 T A 11: 42,073,205 (GRCm39) probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm14137 A G 2: 119,005,572 (GRCm39) T44A possibly damaging Het
H2bl1 T A 13: 99,120,974 (GRCm39) R17S probably benign Het
Herc2 T C 7: 55,841,013 (GRCm39) M3444T probably benign Het
Igsf5 T C 16: 96,197,648 (GRCm39) S208P possibly damaging Het
Ino80b A G 6: 83,102,066 (GRCm39) L12P possibly damaging Het
Insrr A G 3: 87,720,272 (GRCm39) D970G probably damaging Het
Iqcf4 G A 9: 106,445,874 (GRCm39) A91V probably benign Het
Itga10 A G 3: 96,564,078 (GRCm39) T911A probably benign Het
Katnip T C 7: 125,469,869 (GRCm39) V1446A probably benign Het
Klhl30 A T 1: 91,285,086 (GRCm39) D314V probably benign Het
Lpcat1 T C 13: 73,659,074 (GRCm39) V330A possibly damaging Het
Myef2l T C 3: 10,154,239 (GRCm39) I336T probably damaging Het
Nhlrc3 A T 3: 53,359,944 (GRCm39) D306E possibly damaging Het
Notum T A 11: 120,548,766 (GRCm39) I187F probably damaging Het
Nphp3 T C 9: 103,892,640 (GRCm39) L288P probably damaging Het
Ntrk2 G T 13: 59,019,570 (GRCm39) E394* probably null Het
Pbld2 A G 10: 62,874,931 (GRCm39) K63E probably benign Het
Phc2 T C 4: 128,641,982 (GRCm39) M768T possibly damaging Het
Pik3c2g G A 6: 139,603,561 (GRCm39) C249Y probably damaging Het
Plod1 G A 4: 148,000,772 (GRCm39) probably benign Het
Plscr2 A T 9: 92,172,772 (GRCm39) T9S probably benign Het
Pnrc1 T A 4: 33,246,315 (GRCm39) M215L probably benign Het
Prcp G T 7: 92,577,841 (GRCm39) C370F probably damaging Het
Pter A G 2: 12,983,205 (GRCm39) N70S probably damaging Het
Ptprt G T 2: 161,395,779 (GRCm39) H1131Q probably damaging Het
Rasal2 T C 1: 157,239,432 (GRCm39) D8G possibly damaging Het
Rcn2 A C 9: 55,960,209 (GRCm39) K159Q probably benign Het
Rex2 T A 4: 147,141,972 (GRCm39) C153* probably null Het
Rps6ka2 T C 17: 7,437,766 (GRCm39) F8S possibly damaging Het
Samd9l A G 6: 3,375,383 (GRCm39) L626S probably damaging Het
Sptb A G 12: 76,667,428 (GRCm39) probably null Het
Srgap3 A T 6: 112,793,571 (GRCm39) V135D probably damaging Het
Srsf7 T C 17: 80,514,682 (GRCm39) probably benign Het
Tacc2 A G 7: 130,228,255 (GRCm39) T1647A probably benign Het
Thap12 G T 7: 98,352,612 (GRCm39) A6S probably damaging Het
Tmem33 T A 5: 67,425,894 (GRCm39) L146* probably null Het
Trip13 C A 13: 74,084,378 (GRCm39) E36* probably null Het
Vkorc1l1 T A 5: 129,971,079 (GRCm39) C23S probably damaging Het
Vmn1r20 G A 6: 57,409,112 (GRCm39) R146H probably benign Het
Vmn1r222 T A 13: 23,416,965 (GRCm39) I83F probably benign Het
Vmn2r107 A T 17: 20,576,044 (GRCm39) I125F probably benign Het
Vmn2r116 A G 17: 23,605,736 (GRCm39) D216G probably damaging Het
Vwa3a C T 7: 120,394,874 (GRCm39) T898I probably benign Het
Wdfy3 T C 5: 102,116,812 (GRCm39) D76G probably damaging Het
Wdhd1 T C 14: 47,510,579 (GRCm39) D148G possibly damaging Het
Xylt1 T C 7: 117,255,960 (GRCm39) I844T probably damaging Het
Zfp106 A T 2: 120,353,185 (GRCm39) V1535D probably damaging Het
Zfp385b A T 2: 77,244,323 (GRCm39) L315Q possibly damaging Het
Zfp458 T A 13: 67,404,870 (GRCm39) H523L probably damaging Het
Zfp712 T C 13: 67,189,393 (GRCm39) H378R probably damaging Het
Zic1 T C 9: 91,246,556 (GRCm39) Y172C probably damaging Het
Other mutations in Or6k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Or6k2 APN 1 173,986,423 (GRCm39) missense probably damaging 1.00
IGL02479:Or6k2 APN 1 173,986,520 (GRCm39) nonsense probably null
IGL03190:Or6k2 APN 1 173,987,110 (GRCm39) missense probably damaging 0.99
IGL03270:Or6k2 APN 1 173,987,119 (GRCm39) missense probably benign 0.04
R0645:Or6k2 UTSW 1 173,986,920 (GRCm39) missense probably benign 0.00
R0834:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R1432:Or6k2 UTSW 1 173,986,483 (GRCm39) missense possibly damaging 0.67
R1508:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R2351:Or6k2 UTSW 1 173,986,486 (GRCm39) missense probably damaging 0.99
R3440:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R3441:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R4571:Or6k2 UTSW 1 173,986,494 (GRCm39) missense possibly damaging 0.77
R5072:Or6k2 UTSW 1 173,986,527 (GRCm39) missense probably damaging 1.00
R6060:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
R6166:Or6k2 UTSW 1 173,986,659 (GRCm39) missense probably benign 0.43
R6228:Or6k2 UTSW 1 173,979,712 (GRCm39) missense probably benign 0.00
R6272:Or6k2 UTSW 1 173,986,741 (GRCm39) missense probably benign 0.02
R6400:Or6k2 UTSW 1 173,986,830 (GRCm39) missense probably damaging 0.99
R7581:Or6k2 UTSW 1 173,986,337 (GRCm39) splice site probably null
R7677:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 1.00
R7823:Or6k2 UTSW 1 173,987,254 (GRCm39) missense probably benign 0.12
R7829:Or6k2 UTSW 1 173,986,425 (GRCm39) missense probably benign 0.00
R8077:Or6k2 UTSW 1 173,979,411 (GRCm39) unclassified probably benign
R8519:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 0.99
R9106:Or6k2 UTSW 1 173,986,369 (GRCm39) missense probably benign 0.00
R9205:Or6k2 UTSW 1 173,986,456 (GRCm39) missense probably benign 0.33
R9507:Or6k2 UTSW 1 173,986,552 (GRCm39) missense possibly damaging 0.94
R9797:Or6k2 UTSW 1 173,986,417 (GRCm39) missense probably benign
Z1187:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Z1192:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GCTCACTGCTGGTTCTTGTG -3'
(R):5'- ATGTCCTTATTTCTCAGGCTGT -3'

Sequencing Primer
(F):5'- CATCCTTCTACCTGAGATTGTGTGG -3'
(R):5'- TAGGATTGAAAAGAGGGGCAAACAC -3'
Posted On 2018-07-23