Incidental Mutation 'R6295:Fbxw16'
ID 527942
Institutional Source Beutler Lab
Gene Symbol Fbxw16
Ensembl Gene ENSMUSG00000074062
Gene Name F-box and WD-40 domain protein 16
Synonyms 7420402K12Rik
MMRRC Submission 044463-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6295 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 109261386-109278208 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 109277837 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000082051 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084984]
AlphaFold Q497Z0
Predicted Effect probably benign
Transcript: ENSMUST00000084984
SMART Domains Protein: ENSMUSP00000082051
Gene: ENSMUSG00000074062

DomainStartEndE-ValueType
FBOX 5 45 2.72e-6 SMART
SCOP:d1e1aa_ 128 249 3e-5 SMART
Blast:WD40 137 176 1e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196410
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197559
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A C 12: 118,838,379 (GRCm39) V1061G probably damaging Het
Acap1 A G 11: 69,781,413 (GRCm39) probably null Het
Apbb1 A G 7: 105,215,902 (GRCm39) F112L probably benign Het
Atg9a A G 1: 75,161,702 (GRCm39) S615P probably benign Het
Atp8a2 G A 14: 60,249,848 (GRCm39) R548* probably null Het
Bbof1 A T 12: 84,457,942 (GRCm39) N69I possibly damaging Het
Bcl2l14 T A 6: 134,404,370 (GRCm39) V186D probably benign Het
Bmp1 T G 14: 70,728,823 (GRCm39) Y583S possibly damaging Het
Boc A C 16: 44,312,711 (GRCm39) S586R probably benign Het
Btbd9 A T 17: 30,518,710 (GRCm39) probably null Het
Cacna1e T C 1: 154,317,919 (GRCm39) M1180V probably damaging Het
Ciao1 T C 2: 127,088,376 (GRCm39) H149R probably damaging Het
Cops5 T C 1: 10,100,920 (GRCm39) probably benign Het
Doc2b C T 11: 75,671,093 (GRCm39) R209Q probably damaging Het
Doc2b T C 11: 75,686,451 (GRCm39) Y90C probably benign Het
Ep400 A G 5: 110,901,675 (GRCm39) F481L probably benign Het
Fat4 T A 3: 39,061,229 (GRCm39) probably null Het
Fbxw27 T C 9: 109,601,154 (GRCm39) E17G possibly damaging Het
Gm29735 G A 7: 141,710,367 (GRCm39) P162S unknown Het
Gypa T G 8: 81,222,969 (GRCm39) S24R unknown Het
Hdhd5 T C 6: 120,495,485 (GRCm39) N153D probably benign Het
Ibsp C A 5: 104,449,987 (GRCm39) probably null Het
Klhdc3 C T 17: 46,988,972 (GRCm39) V73I probably benign Het
Lrrc37a T C 11: 103,388,459 (GRCm39) E2322G unknown Het
Lrrtm3 T C 10: 63,765,913 (GRCm39) H558R probably benign Het
Mbtd1 C T 11: 93,823,058 (GRCm39) H493Y possibly damaging Het
Mphosph9 A G 5: 124,458,978 (GRCm39) V64A possibly damaging Het
Nthl1 C T 17: 24,857,475 (GRCm39) R251C probably damaging Het
Numa1 G A 7: 101,649,974 (GRCm39) R1235H probably benign Het
Opn1sw T A 6: 29,379,413 (GRCm39) Y197F possibly damaging Het
Or10a3m T C 7: 108,312,845 (GRCm39) V95A probably damaging Het
Pcca A T 14: 122,896,187 (GRCm39) I268F probably benign Het
Per2 A T 1: 91,377,594 (GRCm39) D76E unknown Het
Pfas T C 11: 68,888,825 (GRCm39) N374S probably benign Het
Pomk C A 8: 26,472,955 (GRCm39) V333F probably damaging Het
Ptgfr T C 3: 151,540,926 (GRCm39) E194G probably benign Het
Ptpn14 C T 1: 189,582,997 (GRCm39) P615S probably damaging Het
Pyroxd1 T C 6: 142,300,479 (GRCm39) I203T probably benign Het
Rgs22 T C 15: 36,087,520 (GRCm39) N466S probably benign Het
Rpl3l G A 17: 24,952,966 (GRCm39) V309I probably benign Het
Rtkn2 C T 10: 67,815,529 (GRCm39) probably benign Het
Sec16a C T 2: 26,318,253 (GRCm39) A1613T probably damaging Het
Sis T A 3: 72,874,103 (GRCm39) T33S probably damaging Het
Slc22a4 C A 11: 53,898,634 (GRCm39) V153F possibly damaging Het
Stxbp1 C G 2: 32,684,621 (GRCm39) E603Q probably damaging Het
Tiam2 A G 17: 3,559,831 (GRCm39) S1291G probably damaging Het
Tmem94 T A 11: 115,687,572 (GRCm39) L1144M probably damaging Het
Ttn G A 2: 76,579,673 (GRCm39) T23740M probably damaging Het
Vmn1r201 T C 13: 22,659,533 (GRCm39) V249A probably benign Het
Wdr7 T A 18: 63,888,182 (GRCm39) C552S probably damaging Het
Other mutations in Fbxw16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02139:Fbxw16 APN 9 109,265,754 (GRCm39) missense probably benign 0.34
IGL02801:Fbxw16 APN 9 109,270,144 (GRCm39) missense possibly damaging 0.73
milky_way UTSW 9 109,270,318 (GRCm39) missense probably damaging 1.00
R0041:Fbxw16 UTSW 9 109,277,232 (GRCm39) missense probably damaging 1.00
R0245:Fbxw16 UTSW 9 109,265,236 (GRCm39) missense possibly damaging 0.93
R0389:Fbxw16 UTSW 9 109,261,550 (GRCm39) missense probably benign 0.03
R0652:Fbxw16 UTSW 9 109,265,236 (GRCm39) missense possibly damaging 0.93
R1693:Fbxw16 UTSW 9 109,265,327 (GRCm39) missense possibly damaging 0.74
R1772:Fbxw16 UTSW 9 109,268,650 (GRCm39) missense possibly damaging 0.91
R1965:Fbxw16 UTSW 9 109,270,289 (GRCm39) missense probably damaging 1.00
R2190:Fbxw16 UTSW 9 109,265,739 (GRCm39) missense probably damaging 1.00
R2334:Fbxw16 UTSW 9 109,267,429 (GRCm39) missense probably benign 0.16
R3800:Fbxw16 UTSW 9 109,265,665 (GRCm39) missense probably damaging 0.99
R3976:Fbxw16 UTSW 9 109,268,697 (GRCm39) missense probably benign 0.42
R4298:Fbxw16 UTSW 9 109,275,625 (GRCm39) missense probably benign 0.00
R4914:Fbxw16 UTSW 9 109,267,245 (GRCm39) missense probably benign 0.01
R4948:Fbxw16 UTSW 9 109,267,415 (GRCm39) missense probably damaging 1.00
R4995:Fbxw16 UTSW 9 109,270,318 (GRCm39) missense probably damaging 1.00
R5057:Fbxw16 UTSW 9 109,270,232 (GRCm39) missense probably damaging 1.00
R5077:Fbxw16 UTSW 9 109,270,117 (GRCm39) critical splice donor site probably null
R5111:Fbxw16 UTSW 9 109,265,796 (GRCm39) missense probably benign 0.11
R5294:Fbxw16 UTSW 9 109,265,712 (GRCm39) missense probably benign 0.34
R5901:Fbxw16 UTSW 9 109,270,285 (GRCm39) missense probably benign 0.06
R6303:Fbxw16 UTSW 9 109,278,169 (GRCm39) missense probably benign 0.00
R6664:Fbxw16 UTSW 9 109,267,326 (GRCm39) missense probably benign 0.27
R6670:Fbxw16 UTSW 9 109,267,280 (GRCm39) missense probably damaging 1.00
R6890:Fbxw16 UTSW 9 109,265,810 (GRCm39) missense probably benign 0.14
R7056:Fbxw16 UTSW 9 109,265,352 (GRCm39) missense possibly damaging 0.50
R7073:Fbxw16 UTSW 9 109,270,123 (GRCm39) missense probably damaging 1.00
R7344:Fbxw16 UTSW 9 109,278,103 (GRCm39) missense probably benign 0.00
R7396:Fbxw16 UTSW 9 109,278,091 (GRCm39) missense probably damaging 1.00
R7464:Fbxw16 UTSW 9 109,268,619 (GRCm39) missense possibly damaging 0.50
R7568:Fbxw16 UTSW 9 109,268,657 (GRCm39) missense possibly damaging 0.49
R7735:Fbxw16 UTSW 9 109,270,135 (GRCm39) missense probably damaging 1.00
R7808:Fbxw16 UTSW 9 109,277,222 (GRCm39) missense probably damaging 0.96
R7998:Fbxw16 UTSW 9 109,265,766 (GRCm39) missense probably damaging 1.00
R9019:Fbxw16 UTSW 9 109,270,135 (GRCm39) missense probably damaging 1.00
R9111:Fbxw16 UTSW 9 109,265,679 (GRCm39) missense probably damaging 1.00
R9216:Fbxw16 UTSW 9 109,276,887 (GRCm39) missense probably damaging 1.00
R9758:Fbxw16 UTSW 9 109,278,169 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGTGCAGCCTGTTCCATTC -3'
(R):5'- ACTCAGTCTTGGAGTCTCGG -3'

Sequencing Primer
(F):5'- GTGGTTGATTTGACCCAAAACTCCTG -3'
(R):5'- AGTCTTGGAGTCTCGGCTACC -3'
Posted On 2018-07-23