|Institutional Source||Beutler Lab|
|Gene Name||interleukin 1 receptor antagonist|
|Is this an essential gene?||Probably non essential (E-score: 0.080)|
|Stock #||R6662 (G1)|
|Chromosomal Location||24336853-24351494 bp(+) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||A to T at 24336875 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000141269 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000114487] [ENSMUST00000142093]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (46/46)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
PHENOTYPE: Nullizygous mutations of this gene may result in decreased body weight, increased inflammatory response to turpentine and LPS, decreased susceptibility to bacterial infection, psoriasis, aortitis, rheumatoid arthritis, and abnormal dendritic and CD4-positive T cell morphology. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Il1rn||
(F):5'- GGCTTCTGCTAGACTGAGTC -3'
(R):5'- GGCCAGATTTTCCTGATAGCC -3'
(F):5'- TAGACTGAGTCACGCCTCTG -3'
(R):5'- CATTGAGCATTGAGTCAACACTAGCG -3'