Incidental Mutation 'R6662:Slco1a6'
ID 528019
Institutional Source Beutler Lab
Gene Symbol Slco1a6
Ensembl Gene ENSMUSG00000079262
Gene Name solute carrier organic anion transporter family, member 1a6
Synonyms Slc21a13, Oatp-5, organic anion-transporting polypeptide, 4930422F19Rik
MMRRC Submission 044782-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6662 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 142031487-142131903 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 142078941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 118 (T118I)
Ref Sequence ENSEMBL: ENSMUSP00000107458 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111827]
AlphaFold Q99J94
Predicted Effect probably damaging
Transcript: ENSMUST00000111827
AA Change: T118I

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000107458
Gene: ENSMUSG00000079262
AA Change: T118I

DomainStartEndE-ValueType
Pfam:MFS_1 21 421 7.8e-26 PFAM
Pfam:OATP 21 597 1.3e-163 PFAM
Pfam:Kazal_2 445 486 2.7e-11 PFAM
transmembrane domain 600 619 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172984
Meta Mutation Damage Score 0.1622 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 A G 19: 57,062,285 (GRCm39) probably null Het
Acox1 A G 11: 116,066,149 (GRCm39) Y418H probably damaging Het
Akr1b1 C T 6: 34,286,939 (GRCm39) V206M possibly damaging Het
Aldh3a1 G A 11: 61,105,481 (GRCm39) V196I probably benign Het
Aox3 A G 1: 58,157,774 (GRCm39) K44E probably damaging Het
Bad T A 19: 6,928,438 (GRCm39) probably benign Het
BC034090 G T 1: 155,102,085 (GRCm39) Q60K possibly damaging Het
Casp6 A G 3: 129,705,875 (GRCm39) T181A probably benign Het
Catsperg2 G A 7: 29,418,938 (GRCm39) probably benign Het
Ccdc14 T C 16: 34,511,164 (GRCm39) L46P probably damaging Het
Ces1b A G 8: 93,790,697 (GRCm39) L364S probably benign Het
Cfap45 T C 1: 172,357,417 (GRCm39) I15T probably benign Het
Dph5 G A 3: 115,722,205 (GRCm39) E228K probably benign Het
Fat4 G T 3: 39,010,970 (GRCm39) L2023F possibly damaging Het
Garem1 T C 18: 21,281,304 (GRCm39) N351D probably benign Het
Grm2 C T 9: 106,525,252 (GRCm39) A488T probably benign Het
Ifit3b A G 19: 34,589,337 (GRCm39) E171G probably damaging Het
Il1rn A T 2: 24,226,887 (GRCm39) probably null Het
Itih5 A T 2: 10,253,992 (GRCm39) I748F probably benign Het
Kcnh5 C A 12: 75,054,385 (GRCm39) D520Y probably damaging Het
Mgat5 C A 1: 127,396,974 (GRCm39) H574N probably damaging Het
Moxd1 A C 10: 24,160,658 (GRCm39) D437A probably damaging Het
Mybpc2 A G 7: 44,155,590 (GRCm39) F888L probably benign Het
Ncs1 T A 2: 31,177,372 (GRCm39) L183Q probably damaging Het
Neto2 A T 8: 86,389,844 (GRCm39) D206E probably damaging Het
Omp A G 7: 97,794,546 (GRCm39) L27P probably damaging Het
Oxsm A G 14: 16,242,287 (GRCm38) S161P probably benign Het
Pate6 C A 9: 35,701,296 (GRCm39) R6M possibly damaging Het
Pde4b A G 4: 102,459,095 (GRCm39) I381M possibly damaging Het
Pramel5 A T 4: 143,999,675 (GRCm39) N137K probably benign Het
Prss33 T C 17: 24,052,934 (GRCm39) S247G probably damaging Het
Rassf9 T A 10: 102,381,899 (GRCm39) L425Q possibly damaging Het
Setx A T 2: 29,048,126 (GRCm39) D1909V probably damaging Het
Slc26a3 A T 12: 31,507,345 (GRCm39) K402* probably null Het
Syne1 A G 10: 5,078,416 (GRCm39) L6769P probably damaging Het
Tas2r107 A T 6: 131,636,452 (GRCm39) V199D possibly damaging Het
Tchp A G 5: 114,858,076 (GRCm39) probably null Het
Trdn A T 10: 33,350,483 (GRCm39) N684I probably damaging Het
Trio G T 15: 27,855,082 (GRCm39) T700K probably benign Het
Ttn C T 2: 76,586,242 (GRCm39) V20084I probably benign Het
Ubl3 A T 5: 148,446,116 (GRCm39) Y62* probably null Het
Uckl1 A G 2: 181,215,053 (GRCm39) Y267H possibly damaging Het
Zfp1005 G A 2: 150,108,172 (GRCm39) probably null Het
Zfp786 T C 6: 47,803,920 (GRCm39) N41D probably damaging Het
Zfp983 T C 17: 21,881,001 (GRCm39) S310P probably damaging Het
Other mutations in Slco1a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Slco1a6 APN 6 142,106,743 (GRCm39) missense probably benign 0.00
IGL00430:Slco1a6 APN 6 142,047,377 (GRCm39) nonsense probably null
IGL00541:Slco1a6 APN 6 142,042,025 (GRCm39) missense possibly damaging 0.67
IGL01340:Slco1a6 APN 6 142,055,109 (GRCm39) missense possibly damaging 0.71
IGL01693:Slco1a6 APN 6 142,078,935 (GRCm39) nonsense probably null
IGL01713:Slco1a6 APN 6 142,032,293 (GRCm39) missense possibly damaging 0.87
IGL01828:Slco1a6 APN 6 142,042,137 (GRCm39) missense probably damaging 1.00
IGL02049:Slco1a6 APN 6 142,047,309 (GRCm39) splice site probably benign
IGL02085:Slco1a6 APN 6 142,032,200 (GRCm39) missense probably benign 0.00
IGL02245:Slco1a6 APN 6 142,055,150 (GRCm39) missense probably damaging 1.00
IGL02549:Slco1a6 APN 6 142,042,141 (GRCm39) splice site probably benign
IGL02698:Slco1a6 APN 6 142,048,737 (GRCm39) nonsense probably null
IGL02948:Slco1a6 APN 6 142,078,961 (GRCm39) splice site probably null
IGL03075:Slco1a6 APN 6 142,048,875 (GRCm39) splice site probably benign
PIT4585001:Slco1a6 UTSW 6 142,055,246 (GRCm39) missense probably damaging 0.99
R0008:Slco1a6 UTSW 6 142,102,948 (GRCm39) unclassified probably benign
R0106:Slco1a6 UTSW 6 142,103,116 (GRCm39) unclassified probably benign
R0106:Slco1a6 UTSW 6 142,103,116 (GRCm39) unclassified probably benign
R0173:Slco1a6 UTSW 6 142,048,848 (GRCm39) missense probably benign 0.10
R1642:Slco1a6 UTSW 6 142,032,160 (GRCm39) missense probably benign 0.00
R1939:Slco1a6 UTSW 6 142,078,956 (GRCm39) missense probably damaging 1.00
R2256:Slco1a6 UTSW 6 142,036,742 (GRCm39) missense probably benign 0.04
R2257:Slco1a6 UTSW 6 142,036,742 (GRCm39) missense probably benign 0.04
R2696:Slco1a6 UTSW 6 142,058,662 (GRCm39) missense probably damaging 1.00
R2902:Slco1a6 UTSW 6 142,042,046 (GRCm39) missense probably damaging 1.00
R4602:Slco1a6 UTSW 6 142,047,378 (GRCm39) missense probably benign 0.00
R4611:Slco1a6 UTSW 6 142,047,378 (GRCm39) missense probably benign 0.00
R4958:Slco1a6 UTSW 6 142,091,431 (GRCm39) missense probably damaging 1.00
R5256:Slco1a6 UTSW 6 142,078,427 (GRCm39) missense probably benign 0.39
R5347:Slco1a6 UTSW 6 142,032,325 (GRCm39) missense probably damaging 0.98
R6130:Slco1a6 UTSW 6 142,032,155 (GRCm39) missense probably benign 0.26
R6384:Slco1a6 UTSW 6 142,055,105 (GRCm39) missense probably benign 0.01
R6543:Slco1a6 UTSW 6 142,078,872 (GRCm39) missense probably benign 0.00
R6687:Slco1a6 UTSW 6 142,045,076 (GRCm39) missense possibly damaging 0.91
R6702:Slco1a6 UTSW 6 142,048,826 (GRCm39) missense probably damaging 0.99
R7012:Slco1a6 UTSW 6 142,032,287 (GRCm39) missense probably benign 0.02
R7140:Slco1a6 UTSW 6 142,048,745 (GRCm39) missense probably benign 0.00
R7392:Slco1a6 UTSW 6 142,103,003 (GRCm39) missense probably benign 0.00
R7399:Slco1a6 UTSW 6 142,036,794 (GRCm39) missense probably benign 0.01
R7476:Slco1a6 UTSW 6 142,048,727 (GRCm39) missense possibly damaging 0.71
R7621:Slco1a6 UTSW 6 142,106,743 (GRCm39) missense probably damaging 0.96
R7633:Slco1a6 UTSW 6 142,091,481 (GRCm39) missense probably damaging 1.00
R8139:Slco1a6 UTSW 6 142,035,626 (GRCm39) missense probably damaging 1.00
R8177:Slco1a6 UTSW 6 142,047,460 (GRCm39) missense probably damaging 1.00
R8768:Slco1a6 UTSW 6 142,078,897 (GRCm39) missense probably benign 0.01
R8957:Slco1a6 UTSW 6 142,091,493 (GRCm39) missense probably damaging 0.99
R9090:Slco1a6 UTSW 6 142,035,575 (GRCm39) missense probably damaging 1.00
R9271:Slco1a6 UTSW 6 142,035,575 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCCAGTGTGGTATTATAACCTTTC -3'
(R):5'- CTACATGTTCAGCCCAATGATAC -3'

Sequencing Primer
(F):5'- CCTTTCATAAAAGAGCATTCTGTAGC -3'
(R):5'- GTGCAGCAAGTACTTCACATG -3'
Posted On 2018-07-24