Incidental Mutation 'R6652:Or6y1'
ID 528080
Institutional Source Beutler Lab
Gene Symbol Or6y1
Ensembl Gene ENSMUSG00000066671
Gene Name olfactory receptor family 6 subfamily Y member 1
Synonyms EG546747, Olfr413-ps1, GA_x6K02T2P20D-20731742-20730694, Olfr220, MOR103-13P, MOR103-17, GA_x6K02SYWY4V-595-239
MMRRC Submission 044773-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R6652 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 174276191-174277168 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 174276627 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 146 (C146Y)
Ref Sequence ENSEMBL: ENSMUSP00000141919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085861] [ENSMUST00000194229]
AlphaFold E9Q050
Predicted Effect probably damaging
Transcript: ENSMUST00000085861
AA Change: C146Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083023
Gene: ENSMUSG00000066671
AA Change: C146Y

DomainStartEndE-ValueType
Pfam:7tm_4 36 314 1.2e-51 PFAM
Pfam:7tm_1 46 295 3.6e-25 PFAM
low complexity region 315 325 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000194229
AA Change: C146Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141919
Gene: ENSMUSG00000066671
AA Change: C146Y

DomainStartEndE-ValueType
Pfam:7tm_1 46 295 6e-33 PFAM
Pfam:7tm_4 144 288 1.4e-44 PFAM
low complexity region 315 325 N/A INTRINSIC
Meta Mutation Damage Score 0.3317 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.7%
Validation Efficiency 100% (42/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,846,164 (GRCm39) D605G probably damaging Het
Cfh A T 1: 140,071,806 (GRCm39) I294N probably benign Het
Clk3 A G 9: 57,669,078 (GRCm39) S49P probably damaging Het
Cmya5 A G 13: 93,229,403 (GRCm39) V1895A probably benign Het
Cmya5 T C 13: 93,229,547 (GRCm39) D1847G probably damaging Het
Cwf19l1 T C 19: 44,103,138 (GRCm39) D359G probably benign Het
Dag1 A T 9: 108,086,289 (GRCm39) M284K probably damaging Het
Ergic2 T C 6: 148,091,079 (GRCm39) Y211C probably damaging Het
Espnl A C 1: 91,272,421 (GRCm39) I594L probably benign Het
Fam193b A G 13: 55,690,603 (GRCm39) S226P probably damaging Het
Fat2 T A 11: 55,143,088 (GRCm39) I4254L probably benign Het
Fhdc1 T C 3: 84,371,631 (GRCm39) Y108C probably damaging Het
Fut9 G C 4: 25,620,619 (GRCm39) T65S probably benign Het
Gm9507 A T 10: 77,647,493 (GRCm39) probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Grap2 A T 15: 80,532,723 (GRCm39) N297Y probably damaging Het
Igfn1 A G 1: 135,891,609 (GRCm39) F2302S probably damaging Het
Ighv1-81 T A 12: 115,884,051 (GRCm39) I67F probably damaging Het
Kidins220 T A 12: 25,060,059 (GRCm39) probably null Het
Kti12 T A 4: 108,705,730 (GRCm39) S215T probably benign Het
Mc1r G A 8: 124,134,370 (GRCm39) G41D probably damaging Het
Mov10l1 A G 15: 88,878,105 (GRCm39) Y129C probably damaging Het
Mthfsd A T 8: 121,825,560 (GRCm39) L337Q probably damaging Het
Musk C T 4: 58,368,977 (GRCm39) A629V probably damaging Het
Nadsyn1 A T 7: 143,364,955 (GRCm39) M250K probably benign Het
Ncapd2 G A 6: 125,163,233 (GRCm39) H92Y probably benign Het
Or4e5 C T 14: 52,728,250 (GRCm39) R57Q probably benign Het
Plec A T 15: 76,063,974 (GRCm39) V2100E probably damaging Het
Prss37 C A 6: 40,496,090 (GRCm39) probably benign Het
Sebox A T 11: 78,394,631 (GRCm39) E32V probably damaging Het
Senp7 C A 16: 55,944,257 (GRCm39) Q194K probably benign Het
Sfxn3 G A 19: 45,038,354 (GRCm39) probably null Het
Spart G A 3: 55,032,248 (GRCm39) E361K probably benign Het
Stn1 T C 19: 47,496,017 (GRCm39) T334A probably benign Het
Stoml1 A G 9: 58,164,017 (GRCm39) D112G probably damaging Het
Thap2 T A 10: 115,212,441 (GRCm39) D28V probably damaging Het
Ubap2 A T 4: 41,196,743 (GRCm39) N872K possibly damaging Het
Vezt A G 10: 93,806,141 (GRCm39) F757L probably damaging Het
Vmn1r204 T C 13: 22,740,573 (GRCm39) I68T probably damaging Het
Wnt10a A G 1: 74,842,613 (GRCm39) probably null Het
Yipf7 A G 5: 69,698,504 (GRCm39) M1T probably null Het
Zdhhc19 T C 16: 32,316,047 (GRCm39) F48S probably damaging Het
Zfp317 C T 9: 19,558,335 (GRCm39) T183I probably damaging Het
Other mutations in Or6y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00096:Or6y1 APN 1 174,276,233 (GRCm39) missense probably benign 0.00
IGL03369:Or6y1 APN 1 174,276,435 (GRCm39) missense probably damaging 1.00
R1792:Or6y1 UTSW 1 174,276,303 (GRCm39) missense probably benign
R4090:Or6y1 UTSW 1 174,276,500 (GRCm39) missense probably benign 0.01
R4169:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R4769:Or6y1 UTSW 1 174,276,524 (GRCm39) missense possibly damaging 0.80
R6930:Or6y1 UTSW 1 174,276,677 (GRCm39) missense probably damaging 1.00
R7237:Or6y1 UTSW 1 174,276,905 (GRCm39) missense probably benign 0.05
R8039:Or6y1 UTSW 1 174,277,162 (GRCm39) missense unknown
R8187:Or6y1 UTSW 1 174,276,838 (GRCm39) frame shift probably null
R8518:Or6y1 UTSW 1 174,276,742 (GRCm39) nonsense probably null
R9177:Or6y1 UTSW 1 174,276,923 (GRCm39) missense probably damaging 1.00
R9453:Or6y1 UTSW 1 174,276,233 (GRCm39) missense probably benign 0.00
R9757:Or6y1 UTSW 1 174,276,866 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCATCAGTCCCAAGATGCTG -3'
(R):5'- ACAGCAATGACCATGAGGGC -3'

Sequencing Primer
(F):5'- CAAGATGCTGGTAGACTTCCTCAG -3'
(R):5'- GAAGAAGTCTACTAGCTCTGCCTG -3'
Posted On 2018-07-24