Incidental Mutation 'R6734:Tas1r3'
ID 528332
Institutional Source Beutler Lab
Gene Symbol Tas1r3
Ensembl Gene ENSMUSG00000029072
Gene Name taste receptor, type 1, member 3
Synonyms T1r3
MMRRC Submission 044852-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R6734 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 155943725-155947810 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 155945257 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 655 (T655A)
Ref Sequence ENSEMBL: ENSMUSP00000030949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030948] [ENSMUST00000030949] [ENSMUST00000030950] [ENSMUST00000168552]
AlphaFold Q925D8
Predicted Effect probably benign
Transcript: ENSMUST00000030948
SMART Domains Protein: ENSMUSP00000030948
Gene: ENSMUSG00000029071

DomainStartEndE-ValueType
DAX 1 85 2.17e-52 SMART
Pfam:Dishevelled 144 215 1.1e-31 PFAM
low complexity region 217 233 N/A INTRINSIC
low complexity region 235 246 N/A INTRINSIC
PDZ 260 339 3.13e-16 SMART
low complexity region 380 397 N/A INTRINSIC
DEP 425 499 1.47e-26 SMART
Pfam:Dsh_C 503 685 4.2e-67 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000030949
AA Change: T655A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000030949
Gene: ENSMUSG00000029072
AA Change: T655A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 72 469 2e-79 PFAM
Pfam:NCD3G 500 552 1.9e-16 PFAM
Pfam:7tm_3 576 821 9.6e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030950
SMART Domains Protein: ENSMUSP00000030950
Gene: ENSMUSG00000029073

DomainStartEndE-ValueType
Pfam:GLTP 27 179 1.4e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129450
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133184
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141539
Predicted Effect probably benign
Transcript: ENSMUST00000168552
SMART Domains Protein: ENSMUSP00000133137
Gene: ENSMUSG00000029071

DomainStartEndE-ValueType
DAX 1 85 2.17e-52 SMART
Pfam:Dishevelled 90 247 1.7e-60 PFAM
PDZ 260 339 3.13e-16 SMART
low complexity region 380 397 N/A INTRINSIC
DEP 425 499 1.47e-26 SMART
Pfam:Dsh_C 503 685 7.6e-59 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143457
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156997
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156266
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Ano6 A G 15: 95,847,417 (GRCm39) K554R probably damaging Het
Arhgef10 A T 8: 15,025,053 (GRCm39) I703F probably damaging Het
Bbs1 T C 19: 4,953,924 (GRCm39) S80G probably benign Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Camk1 C A 6: 113,311,345 (GRCm39) R352L probably benign Het
Cand1 G A 10: 119,047,897 (GRCm39) P531L possibly damaging Het
Cnot2 G A 10: 116,334,058 (GRCm39) P371S possibly damaging Het
Col24a1 C A 3: 145,214,429 (GRCm39) P1384Q probably benign Het
Csmd2 C A 4: 128,357,606 (GRCm39) T1689K probably benign Het
Cyp26a1 T A 19: 37,689,660 (GRCm39) L452H probably damaging Het
Dcpp2 T C 17: 24,119,545 (GRCm39) Y120H probably damaging Het
Dennd6a G T 14: 26,329,774 (GRCm39) R115L possibly damaging Het
Eml2 T A 7: 18,934,432 (GRCm39) V377E probably benign Het
Fam135b T C 15: 71,334,629 (GRCm39) E855G probably benign Het
Fam149a A T 8: 45,834,478 (GRCm39) I107K probably benign Het
Fam227b A T 2: 125,968,896 (GRCm39) Y59* probably null Het
Fbn2 T C 18: 58,169,032 (GRCm39) E2249G probably damaging Het
Flrt1 T C 19: 7,073,524 (GRCm39) D341G possibly damaging Het
Galnt9 G A 5: 110,768,465 (GRCm39) R587H probably damaging Het
Gsdma2 A G 11: 98,540,416 (GRCm39) T112A possibly damaging Het
Klhl24 T C 16: 19,926,279 (GRCm39) V269A probably damaging Het
Lcorl A G 5: 45,890,839 (GRCm39) S505P probably damaging Het
Liph A G 16: 21,802,707 (GRCm39) S121P probably damaging Het
Lrp4 G A 2: 91,316,242 (GRCm39) V787M possibly damaging Het
Lrrd1 A C 5: 3,900,226 (GRCm39) D177A possibly damaging Het
Mbd1 G A 18: 74,409,114 (GRCm39) R399H probably damaging Het
Naa25 C T 5: 121,576,888 (GRCm39) T879M possibly damaging Het
Naa35 T G 13: 59,756,005 (GRCm39) L147R possibly damaging Het
Ninl C A 2: 150,787,003 (GRCm39) probably null Het
Nrap T C 19: 56,333,941 (GRCm39) D972G probably damaging Het
Or9k7 A G 10: 130,046,126 (GRCm39) F291S probably benign Het
Pdzd2 T C 15: 12,592,551 (GRCm39) E31G probably damaging Het
Plec C T 15: 76,078,603 (GRCm39) E41K probably damaging Het
Plxnb1 A T 9: 108,937,988 (GRCm39) K1245* probably null Het
Ppfia1 T C 7: 144,032,790 (GRCm39) T1263A probably damaging Het
Prex2 G A 1: 11,150,283 (GRCm39) V152I probably damaging Het
Prpf40b C T 15: 99,212,784 (GRCm39) R627W probably damaging Het
Prss3l T C 6: 41,422,321 (GRCm39) Y28C probably damaging Het
Prune2 T G 19: 16,981,097 (GRCm39) F85V probably damaging Het
Rrp1b T G 17: 32,274,278 (GRCm39) probably benign Het
Sec62 A G 3: 30,864,609 (GRCm39) T158A probably benign Het
Sema6a G A 18: 47,412,236 (GRCm39) T526I probably benign Het
Shank1 G T 7: 44,003,110 (GRCm39) A1610S probably benign Het
Slc24a4 T C 12: 102,185,259 (GRCm39) V123A probably damaging Het
Stk11ip T C 1: 75,509,013 (GRCm39) V714A probably benign Het
Tns2 G T 15: 102,011,551 (GRCm39) L10F probably damaging Het
Trmt10c A G 16: 55,854,489 (GRCm39) V382A probably benign Het
Unc45a G C 7: 79,986,746 (GRCm39) T149R probably damaging Het
Zhx3 T G 2: 160,623,640 (GRCm39) I176L probably damaging Het
Zscan12 T A 13: 21,552,966 (GRCm39) C263* probably null Het
Other mutations in Tas1r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01356:Tas1r3 APN 4 155,945,784 (GRCm39) missense probably benign 0.43
IGL01587:Tas1r3 APN 4 155,945,816 (GRCm39) missense probably damaging 0.99
IGL02314:Tas1r3 APN 4 155,945,119 (GRCm39) missense probably damaging 1.00
IGL02747:Tas1r3 APN 4 155,944,917 (GRCm39) missense possibly damaging 0.92
IGL02999:Tas1r3 APN 4 155,946,816 (GRCm39) missense probably damaging 0.97
IGL03026:Tas1r3 APN 4 155,946,300 (GRCm39) unclassified probably benign
IGL03407:Tas1r3 APN 4 155,946,439 (GRCm39) splice site probably null
R0122:Tas1r3 UTSW 4 155,945,290 (GRCm39) missense probably benign
R0827:Tas1r3 UTSW 4 155,945,326 (GRCm39) missense probably benign 0.02
R1700:Tas1r3 UTSW 4 155,946,027 (GRCm39) missense probably benign
R1803:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R1804:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R1883:Tas1r3 UTSW 4 155,946,610 (GRCm39) missense probably damaging 1.00
R1998:Tas1r3 UTSW 4 155,947,377 (GRCm39) missense probably damaging 1.00
R2061:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2104:Tas1r3 UTSW 4 155,946,588 (GRCm39) missense probably benign 0.26
R2127:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2129:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2237:Tas1r3 UTSW 4 155,946,675 (GRCm39) missense possibly damaging 0.58
R2316:Tas1r3 UTSW 4 155,947,772 (GRCm39) missense probably benign
R2847:Tas1r3 UTSW 4 155,944,659 (GRCm39) missense probably benign 0.08
R3619:Tas1r3 UTSW 4 155,945,410 (GRCm39) missense probably damaging 0.99
R3870:Tas1r3 UTSW 4 155,945,810 (GRCm39) missense probably damaging 1.00
R4194:Tas1r3 UTSW 4 155,947,442 (GRCm39) missense probably damaging 1.00
R4195:Tas1r3 UTSW 4 155,947,442 (GRCm39) missense probably damaging 1.00
R4420:Tas1r3 UTSW 4 155,946,789 (GRCm39) missense probably damaging 0.99
R5577:Tas1r3 UTSW 4 155,946,522 (GRCm39) missense probably benign 0.36
R7006:Tas1r3 UTSW 4 155,947,361 (GRCm39) missense possibly damaging 0.93
R7231:Tas1r3 UTSW 4 155,947,283 (GRCm39) missense probably damaging 1.00
R7490:Tas1r3 UTSW 4 155,946,480 (GRCm39) missense probably damaging 0.97
R7895:Tas1r3 UTSW 4 155,947,005 (GRCm39) missense probably damaging 1.00
R8701:Tas1r3 UTSW 4 155,945,503 (GRCm39) missense probably benign 0.00
R8796:Tas1r3 UTSW 4 155,945,848 (GRCm39) missense probably benign 0.15
R8941:Tas1r3 UTSW 4 155,947,600 (GRCm39) critical splice donor site probably null
R9371:Tas1r3 UTSW 4 155,945,059 (GRCm39) missense possibly damaging 0.75
R9576:Tas1r3 UTSW 4 155,946,822 (GRCm39) missense probably benign
R9743:Tas1r3 UTSW 4 155,945,256 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCACTGACCAGTCTGTCAC -3'
(R):5'- ACCAGTGGTCCCCAGAGAAAAG -3'

Sequencing Primer
(F):5'- AGTCTGTCACCACCTCTGG -3'
(R):5'- AGCCAGTTGTGCTGTCAC -3'
Posted On 2018-07-24