Incidental Mutation 'R6695:Or5g27'
ID 528524
Institutional Source Beutler Lab
Gene Symbol Or5g27
Ensembl Gene ENSMUSG00000111179
Gene Name olfactory receptor family 5 subfamily G member 27
Synonyms MOR175-4, GA_x6K02T2Q125-47058060-47059004, Olfr996
MMRRC Submission 044813-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R6695 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85409559-85410626 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85409793 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 70 (D70G)
Ref Sequence ENSEMBL: ENSMUSP00000076330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077075]
AlphaFold Q7TRA0
Predicted Effect probably damaging
Transcript: ENSMUST00000077075
AA Change: D70G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076330
Gene: ENSMUSG00000111179
AA Change: D70G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.2e-52 PFAM
Pfam:7tm_1 41 290 2.7e-16 PFAM
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd9 A T 12: 110,943,497 (GRCm39) L179H probably benign Het
Cacna1h C A 17: 25,612,714 (GRCm39) A370S probably damaging Het
Cc2d2a A T 5: 43,876,019 (GRCm39) I1053F probably damaging Het
Csmd3 A G 15: 47,721,230 (GRCm39) V1467A probably damaging Het
Cyp4f15 T A 17: 32,911,586 (GRCm39) L156* probably null Het
Dmwd T A 7: 18,814,652 (GRCm39) L434Q probably damaging Het
Dtx4 T A 19: 12,450,599 (GRCm39) R538* probably null Het
Fcgbp T A 7: 27,785,695 (GRCm39) C377* probably null Het
Galntl6 G T 8: 58,880,804 (GRCm39) H116Q probably damaging Het
Herc1 T A 9: 66,391,148 (GRCm39) probably null Het
Hydin T G 8: 111,053,092 (GRCm39) S255A probably benign Het
Knstrn G A 2: 118,644,723 (GRCm39) A48T probably damaging Het
Lonrf2 T C 1: 38,852,470 (GRCm39) D127G probably benign Het
Luzp1 T C 4: 136,272,609 (GRCm39) S12P possibly damaging Het
Man2c1 A T 9: 57,048,875 (GRCm39) H822L probably benign Het
Map3k13 G T 16: 21,741,028 (GRCm39) G785V probably benign Het
Mia2 A G 12: 59,219,366 (GRCm39) H454R probably damaging Het
Mib2 G A 4: 155,745,629 (GRCm39) R61C probably damaging Het
Muc15 A T 2: 110,561,616 (GRCm39) L17F probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Nav2 A G 7: 49,114,652 (GRCm39) I879V probably benign Het
Nomo1 T A 7: 45,715,885 (GRCm39) S751T probably benign Het
Or1j10 A T 2: 36,267,117 (GRCm39) S110C probably benign Het
Or5b24 A T 19: 12,912,764 (GRCm39) I221L possibly damaging Het
Pcdhac2 A G 18: 37,278,256 (GRCm39) N412S probably benign Het
Plk5 T C 10: 80,196,035 (GRCm39) S235P probably benign Het
Ppm1j A G 3: 104,692,802 (GRCm39) D437G probably damaging Het
Rab11fip1 T C 8: 27,633,262 (GRCm39) E1148G probably damaging Het
Rad9b T C 5: 122,489,754 (GRCm39) N43S probably damaging Het
Rc3h2 A C 2: 37,304,673 (GRCm39) I29S possibly damaging Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Homo
Spdl1 T A 11: 34,713,830 (GRCm39) probably null Het
Spta1 A T 1: 174,071,608 (GRCm39) probably null Het
Stk32c A T 7: 138,702,880 (GRCm39) V53E probably damaging Het
Strc A T 2: 121,207,705 (GRCm39) F555L probably benign Het
Sugct T G 13: 17,497,815 (GRCm39) N286T possibly damaging Het
Swsap1 A T 9: 21,867,971 (GRCm39) probably null Het
Thbs2 T A 17: 14,894,426 (GRCm39) D807V possibly damaging Het
Tnrc6b A G 15: 80,763,974 (GRCm39) D492G probably damaging Het
Tonsl A T 15: 76,514,018 (GRCm39) S1184T possibly damaging Het
Tpp2 T A 1: 44,022,436 (GRCm39) Y945N probably benign Het
Usp54 G T 14: 20,610,937 (GRCm39) A1293D possibly damaging Het
Vps52 A T 17: 34,182,173 (GRCm39) K516* probably null Het
Zbtb17 T A 4: 141,189,110 (GRCm39) V10D probably damaging Het
Zfp607b T C 7: 27,403,464 (GRCm39) V640A probably benign Het
Other mutations in Or5g27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Or5g27 APN 2 85,409,875 (GRCm39) nonsense probably null
IGL01972:Or5g27 APN 2 85,410,117 (GRCm39) missense probably damaging 1.00
IGL02102:Or5g27 APN 2 85,410,017 (GRCm39) missense probably damaging 0.98
IGL03159:Or5g27 APN 2 85,410,284 (GRCm39) missense probably damaging 0.99
R0539:Or5g27 UTSW 2 85,410,119 (GRCm39) missense probably damaging 0.99
R4275:Or5g27 UTSW 2 85,410,207 (GRCm39) missense probably benign 0.07
R4561:Or5g27 UTSW 2 85,409,964 (GRCm39) missense probably damaging 0.99
R4953:Or5g27 UTSW 2 85,410,069 (GRCm39) nonsense probably null
R5794:Or5g27 UTSW 2 85,409,685 (GRCm39) missense probably benign 0.03
R6061:Or5g27 UTSW 2 85,409,886 (GRCm39) missense possibly damaging 0.48
R6981:Or5g27 UTSW 2 85,409,825 (GRCm39) missense probably benign 0.06
R7030:Or5g27 UTSW 2 85,409,746 (GRCm39) missense possibly damaging 0.56
R7399:Or5g27 UTSW 2 85,409,640 (GRCm39) missense probably benign 0.00
R8914:Or5g27 UTSW 2 85,410,056 (GRCm39) missense possibly damaging 0.72
R9594:Or5g27 UTSW 2 85,409,882 (GRCm39) nonsense probably null
R9686:Or5g27 UTSW 2 85,410,340 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAAGAATCAGACTGTCATGCCTG -3'
(R):5'- CATAATAAGTGTGTACAGCAAGGGC -3'

Sequencing Primer
(F):5'- GAATCAGACTGTCATGCCTGAGTTTC -3'
(R):5'- AGGGCTTACATATGGCTGCATACC -3'
Posted On 2018-07-24