Incidental Mutation 'R6712:Vmn1r231'
| ID |
529183 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r231
|
| Ensembl Gene |
ENSMUSG00000050933 |
| Gene Name |
vomeronasal 1 receptor 231 |
| Synonyms |
V1re7 |
| MMRRC Submission |
044830-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.049)
|
| Stock # |
R6712 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21109978-21110913 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 21109992 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 308
(T308A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056228
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061278]
|
| AlphaFold |
Q8R2A3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000061278
AA Change: T308A
PolyPhen 2
Score 0.535 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: T308A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
6 |
294 |
1.6e-13 |
PFAM |
|
Pfam:V1R
|
36 |
297 |
1.6e-27 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232004
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 96.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap8l |
G |
A |
17: 32,551,862 (GRCm39) |
T443M |
probably damaging |
Het |
| Ankmy1 |
A |
T |
1: 92,798,644 (GRCm39) |
V950D |
probably damaging |
Het |
| Cep350 |
T |
C |
1: 155,733,852 (GRCm39) |
K3014E |
possibly damaging |
Het |
| Col5a3 |
C |
T |
9: 20,690,329 (GRCm39) |
G1162R |
probably damaging |
Het |
| Dmxl2 |
A |
G |
9: 54,318,908 (GRCm39) |
Y1586H |
probably damaging |
Het |
| Dnah11 |
A |
T |
12: 118,014,457 (GRCm39) |
I2010N |
probably damaging |
Het |
| Dock10 |
T |
A |
1: 80,514,583 (GRCm39) |
M1446L |
probably benign |
Het |
| Fcmr |
T |
C |
1: 130,805,588 (GRCm39) |
L274P |
probably damaging |
Het |
| Foxn1 |
T |
G |
11: 78,252,085 (GRCm39) |
D382A |
probably damaging |
Het |
| Gpr179 |
T |
C |
11: 97,226,993 (GRCm39) |
R1721G |
possibly damaging |
Het |
| H2aj |
A |
G |
6: 136,785,524 (GRCm39) |
I63V |
probably benign |
Het |
| Mfsd9 |
T |
C |
1: 40,825,601 (GRCm39) |
|
probably null |
Het |
| Mis18a |
T |
C |
16: 90,524,045 (GRCm39) |
E39G |
possibly damaging |
Het |
| Mmp27 |
A |
T |
9: 7,572,177 (GRCm39) |
T126S |
probably damaging |
Het |
| Myo1c |
C |
T |
11: 75,562,461 (GRCm39) |
P918S |
probably benign |
Het |
| Myo5a |
A |
C |
9: 75,120,182 (GRCm39) |
D1635A |
probably benign |
Het |
| Ngdn |
T |
C |
14: 55,253,645 (GRCm39) |
V11A |
probably benign |
Het |
| Nlrc4 |
A |
T |
17: 74,753,831 (GRCm39) |
M184K |
probably damaging |
Het |
| Or10h28 |
T |
G |
17: 33,488,242 (GRCm39) |
H181Q |
possibly damaging |
Het |
| Or52e15 |
A |
T |
7: 104,645,625 (GRCm39) |
I162K |
possibly damaging |
Het |
| Peli2 |
C |
A |
14: 48,488,051 (GRCm39) |
Q81K |
probably benign |
Het |
| Pfdn2 |
T |
A |
1: 171,185,419 (GRCm39) |
I97K |
probably damaging |
Het |
| Pknox1 |
C |
A |
17: 31,814,290 (GRCm39) |
T205K |
probably benign |
Het |
| Polh |
T |
C |
17: 46,501,655 (GRCm39) |
S179G |
probably benign |
Het |
| Ppp4r4 |
G |
A |
12: 103,562,702 (GRCm39) |
R557Q |
probably damaging |
Het |
| Sipa1 |
A |
T |
19: 5,710,847 (GRCm39) |
D54E |
possibly damaging |
Het |
| Tmc8 |
C |
A |
11: 117,675,639 (GRCm39) |
N185K |
probably benign |
Het |
| Tns1 |
C |
A |
1: 74,118,460 (GRCm39) |
E57* |
probably null |
Het |
| Tyro3 |
G |
A |
2: 119,635,335 (GRCm39) |
A209T |
probably null |
Het |
| Ube2f |
T |
A |
1: 91,204,171 (GRCm39) |
C116S |
possibly damaging |
Het |
| Wwc2 |
T |
A |
8: 48,353,838 (GRCm39) |
M99L |
probably benign |
Het |
| Zfp516 |
C |
T |
18: 82,975,433 (GRCm39) |
R544C |
probably damaging |
Het |
| Zfp764l1 |
A |
T |
7: 126,991,482 (GRCm39) |
H168Q |
probably damaging |
Het |
|
| Other mutations in Vmn1r231 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00233:Vmn1r231
|
APN |
17 |
21,110,828 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02124:Vmn1r231
|
APN |
17 |
21,110,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Vmn1r231
|
APN |
17 |
21,109,997 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0066:Vmn1r231
|
UTSW |
17 |
21,109,998 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0066:Vmn1r231
|
UTSW |
17 |
21,109,998 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0396:Vmn1r231
|
UTSW |
17 |
21,110,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0427:Vmn1r231
|
UTSW |
17 |
21,110,490 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0470:Vmn1r231
|
UTSW |
17 |
21,110,265 (GRCm39) |
nonsense |
probably null |
|
|
R0848:Vmn1r231
|
UTSW |
17 |
21,110,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1692:Vmn1r231
|
UTSW |
17 |
21,110,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1987:Vmn1r231
|
UTSW |
17 |
21,110,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Vmn1r231
|
UTSW |
17 |
21,110,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2105:Vmn1r231
|
UTSW |
17 |
21,110,380 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4440:Vmn1r231
|
UTSW |
17 |
21,110,718 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4634:Vmn1r231
|
UTSW |
17 |
21,110,660 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4646:Vmn1r231
|
UTSW |
17 |
21,110,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4678:Vmn1r231
|
UTSW |
17 |
21,110,489 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4696:Vmn1r231
|
UTSW |
17 |
21,110,901 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4938:Vmn1r231
|
UTSW |
17 |
21,110,613 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5544:Vmn1r231
|
UTSW |
17 |
21,110,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5942:Vmn1r231
|
UTSW |
17 |
21,110,417 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6053:Vmn1r231
|
UTSW |
17 |
21,110,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6692:Vmn1r231
|
UTSW |
17 |
21,110,745 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7131:Vmn1r231
|
UTSW |
17 |
21,110,140 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7854:Vmn1r231
|
UTSW |
17 |
21,110,894 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7918:Vmn1r231
|
UTSW |
17 |
21,110,236 (GRCm39) |
nonsense |
probably null |
|
|
R8187:Vmn1r231
|
UTSW |
17 |
21,110,893 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8238:Vmn1r231
|
UTSW |
17 |
21,110,640 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8313:Vmn1r231
|
UTSW |
17 |
21,110,289 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8525:Vmn1r231
|
UTSW |
17 |
21,110,001 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9276:Vmn1r231
|
UTSW |
17 |
21,110,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF010:Vmn1r231
|
UTSW |
17 |
21,110,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGTAAAGGGCAACTCCTTC -3'
(R):5'- ACATTCTGGTGCTAGTGTCAC -3'
Sequencing Primer
(F):5'- TGAGTAAAGGGCAACTCCTTCATTCC -3'
(R):5'- GCTAGTGTCACTCTTTATTGGC -3'
|
| Posted On |
2018-07-24 |
Incidental Mutation