Incidental Mutation 'R6713:Or2y1'
ID 529218
Institutional Source Beutler Lab
Gene Symbol Or2y1
Ensembl Gene ENSMUSG00000059729
Gene Name olfactory receptor family 2 subfamily Y member 1
Synonyms Olfr1385, Olfr1549-ps1, MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, MOR256-41P
MMRRC Submission 044831-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R6713 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 49385362-49386291 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 49385784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tryptophan at position 141 (C141W)
Ref Sequence ENSEMBL: ENSMUSP00000150035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071807] [ENSMUST00000214948]
AlphaFold Q7TQT1
Predicted Effect probably damaging
Transcript: ENSMUST00000071807
AA Change: C141W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071710
Gene: ENSMUSG00000059729
AA Change: C141W

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 2.1e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 214 9.5e-6 PFAM
Pfam:7tm_1 41 289 2.8e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214948
AA Change: C141W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216450
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.9%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apol10a C T 15: 77,373,051 (GRCm39) T229M possibly damaging Het
Cdh16 G A 8: 105,346,617 (GRCm39) Q226* probably null Het
Cemip A T 7: 83,592,845 (GRCm39) N1227K probably benign Het
Dusp13b A G 14: 21,798,541 (GRCm39) V41A probably damaging Het
F3 C T 3: 121,525,323 (GRCm39) T53I possibly damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fyb2 T A 4: 104,847,432 (GRCm39) M484K probably benign Het
Glb1l A T 1: 75,179,061 (GRCm39) H253Q probably benign Het
Grm8 T C 6: 27,363,190 (GRCm39) E775G probably damaging Het
Hipk3 C T 2: 104,276,916 (GRCm39) V388M probably damaging Het
Ighe T C 12: 113,232,908 (GRCm39) probably benign Het
Kif14 A G 1: 136,453,544 (GRCm39) T1491A probably benign Het
Klre1 A G 6: 129,559,229 (GRCm39) probably null Het
Kpna6 A T 4: 129,547,777 (GRCm39) L257M probably damaging Het
Ldhc G A 7: 46,515,955 (GRCm39) probably null Het
Lekr1 C A 3: 65,591,380 (GRCm39) A39D probably benign Het
Lins1 A G 7: 66,358,230 (GRCm39) T122A probably benign Het
Lrrc40 G A 3: 157,769,350 (GRCm39) R516Q probably benign Het
Meis3 G T 7: 15,916,255 (GRCm39) G72* probably null Het
Mpo A G 11: 87,686,194 (GRCm39) T115A probably damaging Het
Mrgprb5 A G 7: 47,818,537 (GRCm39) V66A probably damaging Het
Myo1c C T 11: 75,562,461 (GRCm39) P918S probably benign Het
Nags C A 11: 102,037,347 (GRCm39) A146E probably benign Het
Nkain4 C T 2: 180,585,970 (GRCm39) G31D probably damaging Het
Or4k1 T A 14: 50,377,181 (GRCm39) H305L probably benign Het
Or5ak24 A C 2: 85,260,883 (GRCm39) C97G probably damaging Het
Or8a1 A G 9: 37,641,560 (GRCm39) C240R probably damaging Het
Otud6b C T 4: 14,822,739 (GRCm39) V122I probably benign Het
Ovca2 C T 11: 75,069,569 (GRCm39) S18N possibly damaging Het
Pax2 A G 19: 44,823,916 (GRCm39) S370G unknown Het
Pias2 G A 18: 77,153,416 (GRCm39) probably null Het
Slc2a10 T C 2: 165,357,128 (GRCm39) F263L probably damaging Het
Slc6a17 T G 3: 107,378,703 (GRCm39) M660L probably benign Het
Smarcc2 A G 10: 128,323,638 (GRCm39) probably null Het
Srcap A G 7: 127,134,089 (GRCm39) T937A probably benign Het
Ssh2 C A 11: 77,340,259 (GRCm39) D470E possibly damaging Het
St8sia1 A T 6: 142,775,008 (GRCm39) probably null Het
Supt20 T A 3: 54,606,022 (GRCm39) I36K possibly damaging Het
Tor1aip2 T A 1: 155,941,155 (GRCm39) L487Q probably damaging Het
Zfp619 G T 7: 39,187,322 (GRCm39) K1117N probably damaging Het
Other mutations in Or2y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Or2y1 APN 11 49,385,793 (GRCm39) missense probably damaging 0.99
IGL02098:Or2y1 APN 11 49,386,224 (GRCm39) missense probably damaging 1.00
IGL03206:Or2y1 APN 11 49,385,536 (GRCm39) missense probably benign 0.05
IGL03402:Or2y1 APN 11 49,385,873 (GRCm39) missense probably benign
R0412:Or2y1 UTSW 11 49,385,594 (GRCm39) missense probably damaging 1.00
R1263:Or2y1 UTSW 11 49,385,848 (GRCm39) missense probably benign
R1371:Or2y1 UTSW 11 49,385,650 (GRCm39) missense probably damaging 1.00
R1488:Or2y1 UTSW 11 49,385,945 (GRCm39) missense probably benign 0.07
R1835:Or2y1 UTSW 11 49,385,497 (GRCm39) missense probably damaging 1.00
R1923:Or2y1 UTSW 11 49,386,131 (GRCm39) missense probably damaging 0.97
R2290:Or2y1 UTSW 11 49,385,857 (GRCm39) missense probably benign
R3738:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R3739:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4034:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4193:Or2y1 UTSW 11 49,386,134 (GRCm39) missense probably damaging 1.00
R4406:Or2y1 UTSW 11 49,385,744 (GRCm39) missense probably benign 0.01
R5239:Or2y1 UTSW 11 49,385,555 (GRCm39) missense possibly damaging 0.93
R6861:Or2y1 UTSW 11 49,385,632 (GRCm39) missense probably benign 0.00
R7916:Or2y1 UTSW 11 49,385,543 (GRCm39) missense probably benign
R8712:Or2y1 UTSW 11 49,385,671 (GRCm39) missense probably benign
R9509:Or2y1 UTSW 11 49,385,476 (GRCm39) missense probably benign
R9624:Or2y1 UTSW 11 49,385,834 (GRCm39) missense possibly damaging 0.94
R9793:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
R9795:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
Z1176:Or2y1 UTSW 11 49,385,894 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCATGGACTTGACAGGACCATC -3'
(R):5'- CAATGTGTCCATAGGAGCCAAG -3'

Sequencing Primer
(F):5'- TTGACAGGACCATCAGCTATG -3'
(R):5'- ACCAAGATTATGGCTCTGGC -3'
Posted On 2018-07-24