Incidental Mutation 'R6713:Nags'
ID |
529223 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nags
|
Ensembl Gene |
ENSMUSG00000048217 |
Gene Name |
N-acetylglutamate synthase |
Synonyms |
1700120E20Rik |
MMRRC Submission |
044831-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.788)
|
Stock # |
R6713 (G1)
|
Quality Score |
199.009 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
102036339-102040303 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 102037347 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Glutamic Acid
at position 146
(A146E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000050258
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055409]
|
AlphaFold |
Q8R4H7 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000055409
AA Change: A146E
PolyPhen 2
Score 0.274 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000050258 Gene: ENSMUSG00000048217 AA Change: A146E
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
48 |
N/A |
INTRINSIC |
low complexity region
|
77 |
90 |
N/A |
INTRINSIC |
Pfam:NAT
|
349 |
514 |
3.5e-50 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123060
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129799
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147252
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.9%
|
Validation Efficiency |
100% (39/39) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008] PHENOTYPE: In the absence of N-carbamyl-L-glutamate and L-citrulline supplementation homozygous null mice develop severe hyperammonemia and die. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Apol10a |
C |
T |
15: 77,373,051 (GRCm39) |
T229M |
possibly damaging |
Het |
Cdh16 |
G |
A |
8: 105,346,617 (GRCm39) |
Q226* |
probably null |
Het |
Cemip |
A |
T |
7: 83,592,845 (GRCm39) |
N1227K |
probably benign |
Het |
Dusp13b |
A |
G |
14: 21,798,541 (GRCm39) |
V41A |
probably damaging |
Het |
F3 |
C |
T |
3: 121,525,323 (GRCm39) |
T53I |
possibly damaging |
Het |
Fan1 |
T |
A |
7: 64,022,234 (GRCm39) |
N340Y |
probably damaging |
Het |
Fyb2 |
T |
A |
4: 104,847,432 (GRCm39) |
M484K |
probably benign |
Het |
Glb1l |
A |
T |
1: 75,179,061 (GRCm39) |
H253Q |
probably benign |
Het |
Grm8 |
T |
C |
6: 27,363,190 (GRCm39) |
E775G |
probably damaging |
Het |
Hipk3 |
C |
T |
2: 104,276,916 (GRCm39) |
V388M |
probably damaging |
Het |
Ighe |
T |
C |
12: 113,232,908 (GRCm39) |
|
probably benign |
Het |
Kif14 |
A |
G |
1: 136,453,544 (GRCm39) |
T1491A |
probably benign |
Het |
Klre1 |
A |
G |
6: 129,559,229 (GRCm39) |
|
probably null |
Het |
Kpna6 |
A |
T |
4: 129,547,777 (GRCm39) |
L257M |
probably damaging |
Het |
Ldhc |
G |
A |
7: 46,515,955 (GRCm39) |
|
probably null |
Het |
Lekr1 |
C |
A |
3: 65,591,380 (GRCm39) |
A39D |
probably benign |
Het |
Lins1 |
A |
G |
7: 66,358,230 (GRCm39) |
T122A |
probably benign |
Het |
Lrrc40 |
G |
A |
3: 157,769,350 (GRCm39) |
R516Q |
probably benign |
Het |
Meis3 |
G |
T |
7: 15,916,255 (GRCm39) |
G72* |
probably null |
Het |
Mpo |
A |
G |
11: 87,686,194 (GRCm39) |
T115A |
probably damaging |
Het |
Mrgprb5 |
A |
G |
7: 47,818,537 (GRCm39) |
V66A |
probably damaging |
Het |
Myo1c |
C |
T |
11: 75,562,461 (GRCm39) |
P918S |
probably benign |
Het |
Nkain4 |
C |
T |
2: 180,585,970 (GRCm39) |
G31D |
probably damaging |
Het |
Or2y1 |
T |
G |
11: 49,385,784 (GRCm39) |
C141W |
probably damaging |
Het |
Or4k1 |
T |
A |
14: 50,377,181 (GRCm39) |
H305L |
probably benign |
Het |
Or5ak24 |
A |
C |
2: 85,260,883 (GRCm39) |
C97G |
probably damaging |
Het |
Or8a1 |
A |
G |
9: 37,641,560 (GRCm39) |
C240R |
probably damaging |
Het |
Otud6b |
C |
T |
4: 14,822,739 (GRCm39) |
V122I |
probably benign |
Het |
Ovca2 |
C |
T |
11: 75,069,569 (GRCm39) |
S18N |
possibly damaging |
Het |
Pax2 |
A |
G |
19: 44,823,916 (GRCm39) |
S370G |
unknown |
Het |
Pias2 |
G |
A |
18: 77,153,416 (GRCm39) |
|
probably null |
Het |
Slc2a10 |
T |
C |
2: 165,357,128 (GRCm39) |
F263L |
probably damaging |
Het |
Slc6a17 |
T |
G |
3: 107,378,703 (GRCm39) |
M660L |
probably benign |
Het |
Smarcc2 |
A |
G |
10: 128,323,638 (GRCm39) |
|
probably null |
Het |
Srcap |
A |
G |
7: 127,134,089 (GRCm39) |
T937A |
probably benign |
Het |
Ssh2 |
C |
A |
11: 77,340,259 (GRCm39) |
D470E |
possibly damaging |
Het |
St8sia1 |
A |
T |
6: 142,775,008 (GRCm39) |
|
probably null |
Het |
Supt20 |
T |
A |
3: 54,606,022 (GRCm39) |
I36K |
possibly damaging |
Het |
Tor1aip2 |
T |
A |
1: 155,941,155 (GRCm39) |
L487Q |
probably damaging |
Het |
Zfp619 |
G |
T |
7: 39,187,322 (GRCm39) |
K1117N |
probably damaging |
Het |
|
Other mutations in Nags |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00336:Nags
|
APN |
11 |
102,039,892 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02308:Nags
|
APN |
11 |
102,039,897 (GRCm39) |
makesense |
probably null |
|
IGL02551:Nags
|
APN |
11 |
102,038,767 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03114:Nags
|
APN |
11 |
102,039,814 (GRCm39) |
missense |
probably damaging |
1.00 |
R0254:Nags
|
UTSW |
11 |
102,038,771 (GRCm39) |
missense |
probably damaging |
1.00 |
R0395:Nags
|
UTSW |
11 |
102,036,530 (GRCm39) |
missense |
unknown |
|
R0573:Nags
|
UTSW |
11 |
102,037,805 (GRCm39) |
missense |
probably damaging |
0.97 |
R3085:Nags
|
UTSW |
11 |
102,036,810 (GRCm39) |
missense |
probably damaging |
1.00 |
R4687:Nags
|
UTSW |
11 |
102,039,022 (GRCm39) |
missense |
probably damaging |
0.97 |
R4852:Nags
|
UTSW |
11 |
102,037,447 (GRCm39) |
nonsense |
probably null |
|
R5093:Nags
|
UTSW |
11 |
102,037,395 (GRCm39) |
missense |
probably damaging |
1.00 |
R5516:Nags
|
UTSW |
11 |
102,036,773 (GRCm39) |
nonsense |
probably null |
|
R6374:Nags
|
UTSW |
11 |
102,037,337 (GRCm39) |
missense |
possibly damaging |
0.58 |
R6741:Nags
|
UTSW |
11 |
102,037,718 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7082:Nags
|
UTSW |
11 |
102,038,298 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7903:Nags
|
UTSW |
11 |
102,037,503 (GRCm39) |
missense |
possibly damaging |
0.61 |
R8234:Nags
|
UTSW |
11 |
102,039,824 (GRCm39) |
missense |
probably damaging |
1.00 |
R9072:Nags
|
UTSW |
11 |
102,038,347 (GRCm39) |
missense |
probably damaging |
1.00 |
R9073:Nags
|
UTSW |
11 |
102,038,347 (GRCm39) |
missense |
probably damaging |
1.00 |
R9090:Nags
|
UTSW |
11 |
102,037,584 (GRCm39) |
missense |
probably benign |
0.25 |
R9271:Nags
|
UTSW |
11 |
102,037,584 (GRCm39) |
missense |
probably benign |
0.25 |
R9546:Nags
|
UTSW |
11 |
102,039,081 (GRCm39) |
missense |
probably damaging |
0.97 |
X0017:Nags
|
UTSW |
11 |
102,036,573 (GRCm39) |
missense |
probably benign |
0.13 |
|
Predicted Primers |
PCR Primer
(F):5'- AGCAGTTAGGGGTTCAGTCG -3'
(R):5'- GTGCCTTAGTTCATCCACCAG -3'
Sequencing Primer
(F):5'- CAAGGTGTCCCAGAGTCCAAG -3'
(R):5'- GCACCTTGCAGCTCTGAG -3'
|
Posted On |
2018-07-24 |