Incidental Mutation 'R6714:Or6c205'
ID 529260
Institutional Source Beutler Lab
Gene Symbol Or6c205
Ensembl Gene ENSMUSG00000096220
Gene Name olfactory receptor family 6 subfamily C member 205
Synonyms Olfr1518, MOR111-6, MOR111-7, MOR111-7, GA_x6K02T2PULF-10936819-10937757, Olfr775
MMRRC Submission 044832-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6714 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129086405-129087343 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129086809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 135 (N135K)
Ref Sequence ENSEMBL: ENSMUSP00000150345 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097163] [ENSMUST00000214109]
AlphaFold Q7TRI4
Predicted Effect possibly damaging
Transcript: ENSMUST00000097163
AA Change: N135K

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132845
Gene: ENSMUSG00000096220
AA Change: N135K

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 9.9e-52 PFAM
Pfam:7tm_1 39 288 9.1e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214109
AA Change: N135K

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.4493 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.9%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
BC061237 A T 14: 44,741,639 (GRCm39) R127S possibly damaging Het
Bub1 C A 2: 127,656,652 (GRCm39) M463I probably benign Het
Cdh23 T C 10: 60,167,609 (GRCm39) I1794V possibly damaging Het
Clspn C T 4: 126,459,561 (GRCm39) T320M probably damaging Het
Coch A C 12: 51,649,520 (GRCm39) D277A probably damaging Het
Col5a3 C T 9: 20,690,329 (GRCm39) G1162R probably damaging Het
Dnah7c A T 1: 46,779,966 (GRCm39) I3223F probably damaging Het
E2f6 G A 12: 16,869,003 (GRCm39) V109I probably damaging Het
Edem2 A T 2: 155,570,809 (GRCm39) probably null Het
Efcab8 A G 2: 153,631,130 (GRCm39) K187E probably damaging Het
Fam184a T C 10: 53,574,979 (GRCm39) N210S probably benign Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fsip2 A G 2: 82,809,878 (GRCm39) I2066V probably benign Het
Fsip2 A G 2: 82,820,430 (GRCm39) T5388A possibly damaging Het
Gpc5 C T 14: 115,789,715 (GRCm39) Q530* probably null Het
Hmcn1 A T 1: 150,579,926 (GRCm39) I1937K probably damaging Het
Hpx G A 7: 105,244,302 (GRCm39) R269C probably damaging Het
Ice1 T C 13: 70,763,382 (GRCm39) probably null Het
Kbtbd4 A T 2: 90,736,183 (GRCm39) probably benign Het
Ldlrad3 T C 2: 101,783,297 (GRCm39) T310A probably benign Het
Lrp4 G A 2: 91,306,710 (GRCm39) S341N possibly damaging Het
Map3k3 T C 11: 106,005,048 (GRCm39) V69A possibly damaging Het
Myh8 T C 11: 67,197,775 (GRCm39) Y1881H probably damaging Het
Nectin4 A T 1: 171,198,218 (GRCm39) probably benign Het
Nhsl1 G T 10: 18,400,459 (GRCm39) V562L possibly damaging Het
Or4k5 A T 14: 50,385,671 (GRCm39) I220K possibly damaging Het
Pcdhga7 T A 18: 37,850,330 (GRCm39) V779E probably benign Het
Peg12 T A 7: 62,113,317 (GRCm39) H260L unknown Het
Qrfpr A T 3: 36,234,405 (GRCm39) M312K possibly damaging Het
Rbl2 T A 8: 91,833,415 (GRCm39) I730N possibly damaging Het
Rbm39 G C 2: 156,003,538 (GRCm39) L281V possibly damaging Het
Setd1b A G 5: 123,295,654 (GRCm39) E1074G unknown Het
Sfr1 A G 19: 47,723,405 (GRCm39) D303G probably damaging Het
Slc7a12 T C 3: 14,546,380 (GRCm39) V175A probably benign Het
Slc8a1 A T 17: 81,715,678 (GRCm39) L785Q probably damaging Het
Spdl1 T A 11: 34,713,830 (GRCm39) probably null Het
Spg11 T C 2: 121,926,212 (GRCm39) I694M probably damaging Het
Tasor2 A T 13: 3,644,189 (GRCm39) F143L probably benign Het
Trpc1 A T 9: 95,605,326 (GRCm39) L111Q probably damaging Het
Tti1 A G 2: 157,848,971 (GRCm39) V756A possibly damaging Het
Unc93a2 T G 17: 7,643,937 (GRCm39) E124A probably benign Het
Usp32 A T 11: 84,917,696 (GRCm39) I777N probably damaging Het
Zbtb8b C T 4: 129,326,776 (GRCm39) E97K probably damaging Het
Zfhx4 A G 3: 5,306,897 (GRCm39) D41G probably damaging Het
Zfp493 A T 13: 67,934,499 (GRCm39) S151C probably benign Het
Zfp503 T C 14: 22,035,825 (GRCm39) T364A probably benign Het
Zfp507 T C 7: 35,487,152 (GRCm39) K772R probably damaging Het
Zfp804b T A 5: 6,819,239 (GRCm39) M1275L probably benign Het
Zfp811 G A 17: 33,016,736 (GRCm39) H434Y probably damaging Het
Other mutations in Or6c205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01025:Or6c205 APN 10 129,086,609 (GRCm39) missense possibly damaging 0.79
IGL01310:Or6c205 APN 10 129,086,865 (GRCm39) missense possibly damaging 0.85
IGL02185:Or6c205 APN 10 129,086,904 (GRCm39) missense possibly damaging 0.60
IGL02887:Or6c205 APN 10 129,086,794 (GRCm39) nonsense probably null
R0584:Or6c205 UTSW 10 129,086,817 (GRCm39) missense probably benign 0.01
R1482:Or6c205 UTSW 10 129,087,012 (GRCm39) missense possibly damaging 0.80
R1845:Or6c205 UTSW 10 129,086,463 (GRCm39) missense probably benign 0.00
R2062:Or6c205 UTSW 10 129,087,001 (GRCm39) nonsense probably null
R2131:Or6c205 UTSW 10 129,086,943 (GRCm39) missense probably benign 0.05
R4975:Or6c205 UTSW 10 129,087,141 (GRCm39) missense probably damaging 1.00
R7803:Or6c205 UTSW 10 129,086,864 (GRCm39) missense probably benign 0.04
R8060:Or6c205 UTSW 10 129,086,915 (GRCm39) missense possibly damaging 0.62
R8177:Or6c205 UTSW 10 129,086,790 (GRCm39) missense probably benign 0.05
R8878:Or6c205 UTSW 10 129,086,883 (GRCm39) missense probably benign 0.39
R9007:Or6c205 UTSW 10 129,086,669 (GRCm39) missense possibly damaging 0.94
R9332:Or6c205 UTSW 10 129,086,972 (GRCm39) missense probably damaging 0.99
R9571:Or6c205 UTSW 10 129,087,182 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- TGCTAGATTCCCAGTTAAAGACTCC -3'
(R):5'- AGCCTCGTATCTGAGCAAGAC -3'

Sequencing Primer
(F):5'- TCCCAGTTAAAGACTCCTATGTAC -3'
(R):5'- CTCGTATCTGAGCAAGACAGCTG -3'
Posted On 2018-07-24