Incidental Mutation 'PIT1430001:Snx29'
ID 529332
Institutional Source Beutler Lab
Gene Symbol Snx29
Ensembl Gene ENSMUSG00000071669
Gene Name sorting nexin 29
Synonyms 4933437K13Rik, LOC381035, LOC385605, Gm11170, Rundc2a
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # PIT1430001 (G1)
Quality Score 100
Status Validated
Chromosome 16
Chromosomal Location 11322908-11755472 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 11403624 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 305 (A305T)
Ref Sequence ENSEMBL: ENSMUSP00000138025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096273] [ENSMUST00000115814] [ENSMUST00000122168] [ENSMUST00000180792]
AlphaFold Q9D3S3
Predicted Effect probably benign
Transcript: ENSMUST00000096273
SMART Domains Protein: ENSMUSP00000093993
Gene: ENSMUSG00000071669

DomainStartEndE-ValueType
low complexity region 103 120 N/A INTRINSIC
coiled coil region 125 206 N/A INTRINSIC
PX 319 422 3.13e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115814
AA Change: A305T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000111481
Gene: ENSMUSG00000071669
AA Change: A305T

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.98e-5 PROSPERO
internal_repeat_1 203 222 2.98e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122168
SMART Domains Protein: ENSMUSP00000113595
Gene: ENSMUSG00000071669

DomainStartEndE-ValueType
low complexity region 88 105 N/A INTRINSIC
coiled coil region 110 191 N/A INTRINSIC
Blast:PX 301 326 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000180792
AA Change: A305T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000138025
Gene: ENSMUSG00000071669
AA Change: A305T

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.63e-5 PROSPERO
internal_repeat_1 203 222 2.63e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
low complexity region 445 462 N/A INTRINSIC
coiled coil region 467 548 N/A INTRINSIC
PX 661 764 3.13e-9 SMART
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 99% (136/137)
Allele List at MGI
Other mutations in this stock
Total: 139 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210016F16Rik T A 13: 58,385,013 K48* probably null Het
2700049A03Rik A T 12: 71,160,386 I524F possibly damaging Het
4930511M06Rik T C 18: 57,384,169 probably benign Het
9330159F19Rik T A 10: 29,224,715 N361K probably damaging Het
Akap9 A G 5: 4,029,849 D1867G probably damaging Het
Ankrd17 T C 5: 90,252,973 T1687A possibly damaging Het
Ap1m2 G A 9: 21,298,252 P376L probably damaging Het
Bicc1 A G 10: 70,957,681 S196P possibly damaging Het
Cacnb2 C T 2: 14,971,601 R228* probably null Het
Ccdc43 A G 11: 102,692,150 S83P probably damaging Het
Ccdc94 C T 17: 55,964,479 probably benign Het
Cdc42bpg T A 19: 6,322,552 probably null Het
Cdh16 C A 8: 104,617,639 M89I probably benign Het
Cecr2 A C 6: 120,758,479 H892P probably benign Het
Chd5 T A 4: 152,370,637 S859T probably damaging Het
Chrd G A 16: 20,738,998 probably null Het
Chrna2 T A 14: 66,149,737 L444Q probably benign Het
Ckap4 A G 10: 84,527,766 S478P probably damaging Het
Cldn4 A T 5: 134,946,660 M29K possibly damaging Het
Clpb T C 7: 101,786,719 V615A possibly damaging Het
Cyb5r4 G A 9: 87,038,738 G142E probably benign Het
Cyp1a1 A G 9: 57,700,911 Y274C probably benign Het
D2hgdh T C 1: 93,826,279 probably benign Het
Dgkh T A 14: 78,581,513 E919V probably damaging Het
Dnah1 A G 14: 31,262,580 Y3916H probably damaging Het
Dpp10 A G 1: 123,341,182 probably benign Het
Egfr A G 11: 16,910,214 T1043A probably benign Het
Elp5 T G 11: 69,967,109 probably null Het
Emilin3 A T 2: 160,908,482 M449K possibly damaging Het
Epb41l4a T G 18: 33,797,347 T686P probably damaging Het
Eppk1 A G 15: 76,105,236 C2482R probably benign Het
Eps8l3 T C 3: 107,884,867 L370P probably damaging Het
Erbin A T 13: 103,859,509 S228R probably damaging Het
Fam149a C T 8: 45,351,706 E280K probably benign Het
Fam78b T C 1: 167,001,744 I60T probably benign Het
Fank1 A T 7: 133,876,800 R197* probably null Het
Fbxo21 C T 5: 117,977,866 S83F possibly damaging Het
Fbxo4 G C 15: 3,979,300 T42R probably benign Het
Fhad1 C G 4: 141,909,749 E1135D probably damaging Het
Fmo1 T A 1: 162,830,053 E506D probably benign Het
Glipr1l2 A T 10: 112,106,840 T231S probably benign Het
Gm11651 C G 11: 105,973,091 probably benign Het
Gm16043 A G 6: 8,426,969 probably null Het
Gm5615 A T 9: 36,534,999 L39* probably null Het
Gm572 T G 4: 148,671,393 W389G unknown Het
Gpc6 G A 14: 117,951,182 W409* probably null Het
Gpr124 A G 8: 27,114,188 M469V possibly damaging Het
Gpr155 T C 2: 73,370,138 T342A probably benign Het
Hcn4 A C 9: 58,859,550 H798P unknown Het
Herc2 T C 7: 56,226,954 S4513P probably damaging Het
Hmcn1 G A 1: 150,808,737 R361C probably benign Het
Hoxa4 G T 6: 52,191,219 P157Q possibly damaging Het
Ift122 A C 6: 115,925,744 probably benign Het
Igfbpl1 G A 4: 45,826,756 S13L unknown Het
Igsf10 T C 3: 59,328,158 D1534G probably benign Het
Il1rap T G 16: 26,710,593 L339V possibly damaging Het
Irf2bpl C T 12: 86,883,455 R148H possibly damaging Het
Ivns1abp A T 1: 151,361,605 R58W probably damaging Het
Kcnq5 C T 1: 21,535,181 V167M probably damaging Het
Lrrcc1 G A 3: 14,545,596 C337Y probably damaging Het
Lrriq3 A G 3: 155,098,870 I56V probably benign Het
Marc1 T G 1: 184,807,049 T37P probably benign Het
Masp1 C A 16: 23,513,944 S47I probably damaging Het
Mcm7 A T 5: 138,167,446 probably benign Het
Mdm2 G T 10: 117,694,935 S210R probably damaging Het
Mical1 A G 10: 41,483,496 R500G possibly damaging Het
Myc A C 15: 61,987,693 T73P probably damaging Het
Myh15 G A 16: 49,196,891 probably null Het
Myh4 A G 11: 67,258,832 M1768V probably benign Het
Nap1l1 T C 10: 111,486,736 Y66H probably damaging Het
Ncoa1 C T 12: 4,323,005 R132K probably benign Het
Nfatc3 C T 8: 106,059,973 S28F possibly damaging Het
Nhlrc3 T A 3: 53,453,629 K235M probably damaging Het
Nrk G A X: 138,978,714 E757K probably damaging Het
Obsl1 G A 1: 75,506,167 P20S probably damaging Het
P2rx7 C T 5: 122,681,216 A567V probably damaging Het
Pcdhb15 G A 18: 37,475,671 R652H probably benign Het
Pcdhga4 T C 18: 37,686,214 V272A probably benign Het
Pcdhgb1 T G 18: 37,681,419 V321G probably damaging Het
Pde2a C G 7: 101,451,477 probably benign Het
Pdhb C T 14: 8,170,425 E109K probably damaging Het
Pkd1 C A 17: 24,569,511 L748M probably damaging Het
Pkd2 A T 5: 104,459,788 E51V probably damaging Het
Pkdrej A G 15: 85,821,292 Y148H probably damaging Het
Polr3gl C G 3: 96,580,912 probably benign Het
Ppfia1 A T 7: 144,498,336 L882Q probably damaging Het
Ppp4r3b G T 11: 29,209,434 R596L probably benign Het
Ppp6r3 G A 19: 3,471,059 Q85* probably null Het
Prss8 A G 7: 127,922,252 probably benign Het
Rab22a A G 2: 173,695,170 I87V probably benign Het
Rev1 A C 1: 38,056,256 probably benign Het
Rnase13 A G 14: 51,922,530 Y51H probably damaging Het
Rnf26 T C 9: 44,112,645 H102R probably damaging Het
Rnf5 T C 17: 34,603,367 E36G probably damaging Het
Rplp1 T G 9: 61,914,376 D18A probably benign Het
Rrs1 C A 1: 9,545,925 D134E probably damaging Het
Sec14l1 A G 11: 117,143,803 Y166C probably damaging Het
Sec14l2 A T 11: 4,109,209 Y153* probably null Het
Senp1 A G 15: 98,084,989 L39P probably damaging Het
Senp2 T A 16: 22,014,114 probably benign Het
Sh3bp1 G A 15: 78,914,024 A19T probably benign Het
Sis G A 3: 72,922,829 P1130S probably damaging Het
Slc16a12 C T 19: 34,677,359 A95T possibly damaging Het
Slc22a4 A G 11: 54,027,957 V7A probably benign Het
Slc35c2 C T 2: 165,277,532 S296N probably benign Het
Slf1 A G 13: 77,050,050 probably benign Het
Slitrk6 A T 14: 110,750,427 V616E possibly damaging Het
Smarca2 T A 19: 26,649,093 M439K probably benign Het
Socs5 C T 17: 87,133,616 probably benign Het
Spata31d1a G T 13: 59,701,196 H1039Q probably benign Het
Srgap1 G A 10: 121,896,753 probably benign Het
Synj1 A T 16: 90,964,508 I650N probably damaging Het
Tac4 A C 11: 95,267,364 probably benign Het
Tbck A C 3: 132,722,726 T281P probably benign Het
Tbx22 T C X: 107,677,005 L62P probably damaging Het
Terf2 G C 8: 107,096,302 R70G probably damaging Het
Tfdp1 C T 8: 13,372,526 P138S probably benign Het
Tigd2 T C 6: 59,211,248 Y367H probably damaging Het
Tmprss15 A T 16: 79,024,752 probably null Het
Tmprss6 C T 15: 78,440,627 G741D probably damaging Het
Tnrc6b A C 15: 80,929,186 T1715P probably damaging Het
Tpcn1 T C 5: 120,548,323 probably benign Het
Trappc2l T C 8: 122,613,135 S35P probably damaging Het
Trim63 T C 4: 134,321,173 probably benign Het
Trim66 G T 7: 109,475,247 D602E probably damaging Het
Trp53bp1 G A 2: 121,271,275 P2S probably damaging Het
Tspan14 A G 14: 40,915,531 L100P probably damaging Het
Tspan15 C T 10: 62,188,120 E260K probably damaging Het
Ubxn10 T C 4: 138,720,888 D159G probably benign Het
Unc5a T G 13: 55,003,896 V713G probably damaging Het
Usp16 C T 16: 87,473,132 A324V probably damaging Het
Uvssa G A 5: 33,402,570 R422Q possibly damaging Het
Wdr34 T C 2: 30,032,135 Y438C probably damaging Het
Wipf1 A C 2: 73,437,602 F151V probably damaging Het
Xpo1 A T 11: 23,276,437 K104N possibly damaging Het
Ybx3 T C 6: 131,379,459 T150A probably damaging Het
Zap70 T A 1: 36,779,169 S312R possibly damaging Het
Zfp534 T G 4: 147,675,423 K263T probably benign Het
Zfp534 T G 4: 147,675,460 N251H probably benign Het
Other mutations in Snx29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00733:Snx29 APN 16 11403502 missense probably damaging 0.97
IGL02207:Snx29 APN 16 11738352 missense probably damaging 1.00
PIT4810001:Snx29 UTSW 16 11400981 missense probably damaging 1.00
R0240:Snx29 UTSW 16 11660553 missense probably damaging 1.00
R0240:Snx29 UTSW 16 11660553 missense probably damaging 1.00
R0276:Snx29 UTSW 16 11738373 missense probably benign 0.01
R0506:Snx29 UTSW 16 11395303 missense probably benign 0.15
R0621:Snx29 UTSW 16 11405787 splice site probably null
R0975:Snx29 UTSW 16 11347871 missense possibly damaging 0.66
R1225:Snx29 UTSW 16 11420686 intron probably benign
R1406:Snx29 UTSW 16 11399793 missense probably benign 0.38
R1406:Snx29 UTSW 16 11399793 missense probably benign 0.38
R1452:Snx29 UTSW 16 11631471 missense probably damaging 1.00
R1515:Snx29 UTSW 16 11399837 critical splice donor site probably null
R1874:Snx29 UTSW 16 11367681 missense probably benign 0.01
R1953:Snx29 UTSW 16 11399783 nonsense probably null
R1978:Snx29 UTSW 16 11367724 missense probably benign 0.23
R2054:Snx29 UTSW 16 11631492 missense probably damaging 1.00
R2105:Snx29 UTSW 16 11511034 missense possibly damaging 0.72
R2128:Snx29 UTSW 16 11400971 missense probably damaging 0.98
R2152:Snx29 UTSW 16 11400843 missense possibly damaging 0.95
R2912:Snx29 UTSW 16 11447453 missense probably damaging 0.99
R2913:Snx29 UTSW 16 11447453 missense probably damaging 0.99
R2914:Snx29 UTSW 16 11447453 missense probably damaging 0.99
R4468:Snx29 UTSW 16 11420701 splice site probably null
R4469:Snx29 UTSW 16 11420701 splice site probably null
R4612:Snx29 UTSW 16 11447495 missense probably damaging 0.99
R4744:Snx29 UTSW 16 11349909 nonsense probably null
R4798:Snx29 UTSW 16 11420736 missense probably damaging 1.00
R5000:Snx29 UTSW 16 11403507 missense probably damaging 0.99
R5165:Snx29 UTSW 16 11420775 missense probably damaging 0.98
R5207:Snx29 UTSW 16 11738363 missense probably damaging 1.00
R5235:Snx29 UTSW 16 11413246 missense possibly damaging 0.94
R5274:Snx29 UTSW 16 11738404 missense probably damaging 1.00
R5277:Snx29 UTSW 16 11399824 missense possibly damaging 0.82
R5462:Snx29 UTSW 16 11511012 missense possibly damaging 0.89
R5655:Snx29 UTSW 16 11755321 missense probably damaging 1.00
R6036:Snx29 UTSW 16 11738437 splice site probably null
R6036:Snx29 UTSW 16 11738437 splice site probably null
R6326:Snx29 UTSW 16 11403566 missense probably benign
R6576:Snx29 UTSW 16 11715056 critical splice donor site probably null
R7406:Snx29 UTSW 16 11755316 missense probably damaging 1.00
R7552:Snx29 UTSW 16 11420785 critical splice donor site probably null
R7555:Snx29 UTSW 16 11400942 missense probably benign 0.02
R7736:Snx29 UTSW 16 11367724 missense probably benign 0.23
R7962:Snx29 UTSW 16 11413357 critical splice donor site probably null
R8101:Snx29 UTSW 16 11571716 missense probably benign 0.16
R8415:Snx29 UTSW 16 11447427 missense probably damaging 1.00
R8549:Snx29 UTSW 16 11715056 critical splice donor site probably null
R9010:Snx29 UTSW 16 11631527 missense probably benign 0.00
R9091:Snx29 UTSW 16 11395291 missense probably benign 0.33
R9099:Snx29 UTSW 16 11660571 missense probably damaging 1.00
R9176:Snx29 UTSW 16 11418864 missense probably benign
R9258:Snx29 UTSW 16 11714935 missense possibly damaging 0.78
R9270:Snx29 UTSW 16 11395291 missense probably benign 0.33
Predicted Primers
Posted On 2018-07-31