Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01111:Mx2'

52936

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mx2

Ensembl Gene

ENSMUSG00000023341

Gene Name

MX dynamin-like GTPase 2

Synonyms

Mx-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

IGL01111

Quality Score

Status

Chromosome

Chromosomal Location

97337281-97362101 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 97359919 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 563 (Q563L)

Ref Sequence

ENSEMBL: ENSMUSP00000024112 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000024112] [ENSMUST00000188251] [ENSMUST00000190447]

AlphaFold

Q9WVP9

Predicted Effect

probably benign
Transcript: ENSMUST00000024112
AA Change: Q563L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000024112
Gene: ENSMUSG00000023341
AA Change: Q563L

Domain	Start	End	E-Value	Type
DYNc	39	282	2.71e-135	SMART
Blast:DYNc	426	539	4e-17	BLAST
GED	562	653	9.88e-30	SMART

Predicted Effect

silent
Transcript: ENSMUST00000188251

SMART Domains

Protein: ENSMUSP00000141038
Gene: ENSMUSG00000023341

Domain	Start	End	E-Value	Type
DYNc	39	282	1.3e-137	SMART
low complexity region	592	603	N/A	INTRINSIC
low complexity region	619	637	N/A	INTRINSIC

Predicted Effect

silent
Transcript: ENSMUST00000190447

SMART Domains

Protein: ENSMUSP00000140229
Gene: ENSMUSG00000023341

Domain	Start	End	E-Value	Type
DYNc	39	282	1.3e-137	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191103

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ammecr1l	T	A	18: 31,905,123 (GRCm39)	Y121*	probably null	Het
Apc	C	T	18: 34,448,189 (GRCm39)	T1661I	possibly damaging	Het
Ccdc13	T	C	9: 121,639,150 (GRCm39)		probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cpt1c	T	C	7: 44,614,978 (GRCm39)	H325R	possibly damaging	Het
Cyp2a22	T	C	7: 26,635,883 (GRCm39)	K227E	probably damaging	Het
Ddx10	T	C	9: 53,071,248 (GRCm39)	K682E	possibly damaging	Het
Dlg2	T	C	7: 91,098,971 (GRCm39)	Y123H	possibly damaging	Het
Dnaaf9	G	T	2: 130,578,518 (GRCm39)	D655E	possibly damaging	Het
Dnah11	A	T	12: 118,106,669 (GRCm39)		probably benign	Het
Dpysl2	T	C	14: 67,071,681 (GRCm39)	E153G	probably damaging	Het
Edrf1	T	A	7: 133,260,282 (GRCm39)	Y64*	probably null	Het
Ephb2	A	T	4: 136,384,721 (GRCm39)	S897T	probably benign	Het
Flt1	A	G	5: 147,515,146 (GRCm39)	I1092T	probably damaging	Het
Gabra4	T	C	5: 71,790,972 (GRCm39)	Y290C	probably damaging	Het
Hectd2	A	T	19: 36,574,520 (GRCm39)	H67L	probably damaging	Het
Itgb2	T	C	10: 77,377,834 (GRCm39)	L11P	probably damaging	Het
Jmy	T	C	13: 93,577,529 (GRCm39)	R880G	probably damaging	Het
Klhl2	A	G	8: 65,202,081 (GRCm39)	C532R	probably damaging	Het
Kpna1	A	G	16: 35,833,259 (GRCm39)		probably benign	Het
L3mbtl2	T	C	15: 81,569,099 (GRCm39)	V591A	possibly damaging	Het
Ldc1	T	A	4: 130,115,518 (GRCm39)	D10V	probably benign	Het
Lepr	A	T	4: 101,671,852 (GRCm39)	N959Y	possibly damaging	Het
Man1a	A	T	10: 53,853,109 (GRCm39)		probably benign	Het
Mov10	A	T	3: 104,708,721 (GRCm39)	S431T	possibly damaging	Het
Nrap	A	T	19: 56,333,990 (GRCm39)	Y874N	probably damaging	Het
Nup160	T	C	2: 90,563,553 (GRCm39)	I1373T	probably benign	Het
Nwd2	A	T	5: 63,964,643 (GRCm39)	D1409V	probably damaging	Het
Obsl1	A	T	1: 75,473,789 (GRCm39)	V744E	possibly damaging	Het
Or51l4	T	A	7: 103,404,580 (GRCm39)	T71S	probably benign	Het
Pgap1	T	C	1: 54,570,102 (GRCm39)	K315R	probably benign	Het
Rab8a	T	C	8: 72,929,700 (GRCm39)	V114A	probably damaging	Het
Sh2d6	T	C	6: 72,496,812 (GRCm39)	T73A	probably benign	Het
Shroom1	A	G	11: 53,354,875 (GRCm39)	E265G	probably damaging	Het
Slc8b1	G	A	5: 120,671,000 (GRCm39)	V529M	probably damaging	Het
Srbd1	G	T	17: 86,405,961 (GRCm39)	A613E	probably benign	Het
Stat1	G	A	1: 52,182,120 (GRCm39)		probably null	Het
Tbck	A	G	3: 132,400,168 (GRCm39)	H73R	probably damaging	Het
Thg1l	A	T	11: 45,839,051 (GRCm39)	D220E	probably damaging	Het
Ttn	C	T	2: 76,608,667 (GRCm39)	G16037D	probably damaging	Het
Unc13b	A	G	4: 43,096,927 (GRCm39)	E100G	possibly damaging	Het
Vmn2r81	T	A	10: 79,083,831 (GRCm39)	D68E	probably benign	Het
Xpo6	T	C	7: 125,728,740 (GRCm39)	T505A	probably benign	Het
Zfp976	T	C	7: 42,265,711 (GRCm39)	K25E	probably damaging	Het

Other mutations in Mx2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00421:Mx2	APN	16	97,345,678 (GRCm39)	missense	probably damaging	0.99
IGL02103:Mx2	APN	16	97,345,795 (GRCm39)	missense	probably damaging	1.00
IGL02678:Mx2	APN	16	97,357,320 (GRCm39)	critical splice donor site	probably null
IGL03166:Mx2	APN	16	97,347,990 (GRCm39)	missense	probably damaging	1.00
IGL03323:Mx2	APN	16	97,347,575 (GRCm39)	missense	probably damaging	0.99
R0254:Mx2	UTSW	16	97,357,295 (GRCm39)	missense	probably benign
R0699:Mx2	UTSW	16	97,345,753 (GRCm39)	missense	probably damaging	1.00
R1180:Mx2	UTSW	16	97,357,209 (GRCm39)	missense	probably damaging	1.00
R1702:Mx2	UTSW	16	97,359,883 (GRCm39)	missense	probably benign
R1762:Mx2	UTSW	16	97,339,903 (GRCm39)	missense	probably benign	0.09
R1922:Mx2	UTSW	16	97,361,551 (GRCm39)	missense	probably benign	0.05
R2049:Mx2	UTSW	16	97,339,903 (GRCm39)	missense	probably benign	0.09
R2141:Mx2	UTSW	16	97,339,903 (GRCm39)	missense	probably benign	0.09
R2142:Mx2	UTSW	16	97,339,903 (GRCm39)	missense	probably benign	0.09
R3010:Mx2	UTSW	16	97,347,999 (GRCm39)	missense	possibly damaging	0.85
R4079:Mx2	UTSW	16	97,357,236 (GRCm39)	missense	probably damaging	0.98
R4553:Mx2	UTSW	16	97,353,205 (GRCm39)	missense	possibly damaging	0.52
R4594:Mx2	UTSW	16	97,348,632 (GRCm39)	nonsense	probably null
R5211:Mx2	UTSW	16	97,348,633 (GRCm39)	missense	probably damaging	1.00
R5785:Mx2	UTSW	16	97,339,904 (GRCm39)	missense	possibly damaging	0.90
R6091:Mx2	UTSW	16	97,347,635 (GRCm39)	missense	probably damaging	1.00
R7250:Mx2	UTSW	16	97,348,664 (GRCm39)	missense	probably damaging	0.99
R7485:Mx2	UTSW	16	97,346,918 (GRCm39)	missense	probably benign	0.11
R7793:Mx2	UTSW	16	97,348,083 (GRCm39)	missense	probably damaging	1.00
R7816:Mx2	UTSW	16	97,346,812 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21