Incidental Mutation 'R6717:Mob4'
ID 529410
Institutional Source Beutler Lab
Gene Symbol Mob4
Ensembl Gene ENSMUSG00000025979
Gene Name MOB family member 4, phocein
Synonyms Prei3, 2610109B12Rik, Mobkl3
MMRRC Submission 044835-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.961) question?
Stock # R6717 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 55170404-55194058 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 55175872 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 39 (M39L)
Ref Sequence ENSEMBL: ENSMUSP00000027122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027122] [ENSMUST00000159311] [ENSMUST00000161122] [ENSMUST00000162364] [ENSMUST00000162553]
AlphaFold Q6PEB6
Predicted Effect possibly damaging
Transcript: ENSMUST00000027122
AA Change: M39L

PolyPhen 2 Score 0.913 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000027122
Gene: ENSMUSG00000025979
AA Change: M39L

DomainStartEndE-ValueType
Pfam:Mob1_phocein 28 168 1.2e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159311
SMART Domains Protein: ENSMUSP00000124790
Gene: ENSMUSG00000025979

DomainStartEndE-ValueType
Pfam:Mob1_phocein 19 189 9.3e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159743
Predicted Effect possibly damaging
Transcript: ENSMUST00000161122
AA Change: M33L

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000162364
AA Change: M33L

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000125415
Gene: ENSMUSG00000025979
AA Change: M33L

DomainStartEndE-ValueType
Mob1_phocein 42 209 1.89e-58 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000162553
AA Change: M1L

PolyPhen 2 Score 0.624 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000124151
Gene: ENSMUSG00000025979
AA Change: M1L

DomainStartEndE-ValueType
Pfam:Mob1_phocein 8 178 3.9e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162930
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 C T 5: 4,114,086 (GRCm39) L3122F probably damaging Het
Atp6v1b1 A T 6: 83,730,632 (GRCm39) probably null Het
Ccdc178 A T 18: 22,153,946 (GRCm39) V621E probably damaging Het
Cfap126 T C 1: 170,941,671 (GRCm39) probably null Het
Cog2 T C 8: 125,252,488 (GRCm39) I64T probably damaging Het
Dhx9 A C 1: 153,349,210 (GRCm39) probably null Het
Efcab7 A G 4: 99,761,931 (GRCm39) D407G possibly damaging Het
Eif2b5 G T 16: 20,324,033 (GRCm39) G459C probably damaging Het
Eml5 T C 12: 98,793,765 (GRCm39) E1168G probably damaging Het
Flnc AGCTGTCAAGTATGCTG AGCTG 6: 29,450,901 (GRCm39) probably benign Het
Fry A G 5: 150,419,777 (GRCm39) T980A probably benign Het
Gabbr2 A G 4: 46,787,574 (GRCm39) V363A possibly damaging Het
Ggt6 T A 11: 72,328,346 (GRCm39) L244* probably null Het
Gprc6a T A 10: 51,491,233 (GRCm39) I768F probably damaging Het
Grk1 G A 8: 13,466,237 (GRCm39) M560I probably benign Het
Hapln4 G A 8: 70,537,740 (GRCm39) E145K probably damaging Het
Hoxd9 C T 2: 74,528,733 (GRCm39) P112S probably benign Het
Ly6g6f T A 17: 35,304,550 (GRCm39) M1L probably benign Het
Mast1 T C 8: 85,644,383 (GRCm39) T849A probably benign Het
Mrgpre A T 7: 143,335,260 (GRCm39) L81Q probably damaging Het
Mst1 T C 9: 107,957,774 (GRCm39) probably null Het
Muc5b A T 7: 141,411,559 (GRCm39) R1502* probably null Het
Or4b13 T A 2: 90,082,868 (GRCm39) I155L probably benign Het
Or5ap2 T A 2: 85,680,567 (GRCm39) I257N probably damaging Het
Or9e1 T C 11: 58,732,113 (GRCm39) Y58H probably damaging Het
Pdc A G 1: 150,208,769 (GRCm39) D84G probably damaging Het
Peak1 T C 9: 56,114,523 (GRCm39) N443D probably benign Het
Pkd1l3 T A 8: 110,341,401 (GRCm39) W85R unknown Het
Pramel31 G T 4: 144,089,227 (GRCm39) V182L probably benign Het
Rfc1 G A 5: 65,459,347 (GRCm39) Q190* probably null Het
Rfc1 A G 5: 65,470,304 (GRCm39) S68P probably damaging Het
Rnf145 T C 11: 44,452,317 (GRCm39) V432A probably benign Het
Ror2 A G 13: 53,273,018 (GRCm39) S204P probably damaging Het
Scn1a T C 2: 66,162,631 (GRCm39) E205G probably damaging Het
Slc2a8 A C 2: 32,866,189 (GRCm39) M277R probably damaging Het
Slc4a1 T C 11: 102,245,249 (GRCm39) Y566C probably damaging Het
Slc6a12 A G 6: 121,331,262 (GRCm39) N185S probably benign Het
Srcap GCTCCTCCTCCTCCTCCT GCTCCTCCTCCTCCT 7: 127,157,482 (GRCm39) probably benign Het
Stk33 T A 7: 108,926,823 (GRCm39) T279S possibly damaging Het
Taok3 A G 5: 117,379,015 (GRCm39) probably benign Het
Tlr11 A G 14: 50,599,561 (GRCm39) T516A probably benign Het
Tmem132c T A 5: 127,641,093 (GRCm39) L1088Q possibly damaging Het
Tmem132d T A 5: 127,861,485 (GRCm39) M879L probably benign Het
Tnk2 A G 16: 32,489,687 (GRCm39) E322G probably damaging Het
Ttc28 T C 5: 111,433,302 (GRCm39) V2081A probably benign Het
Ttn C T 2: 76,624,753 (GRCm39) probably null Het
Zfp105 T C 9: 122,759,373 (GRCm39) V348A possibly damaging Het
Zswim2 T C 2: 83,745,753 (GRCm39) R562G probably benign Het
Other mutations in Mob4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03340:Mob4 APN 1 55,175,867 (GRCm39) missense possibly damaging 0.50
Infinite UTSW 1 55,187,479 (GRCm39) nonsense probably null
Mobius UTSW 1 55,191,881 (GRCm39) nonsense probably null
R4756:Mob4 UTSW 1 55,191,855 (GRCm39) missense probably damaging 0.98
R4831:Mob4 UTSW 1 55,191,899 (GRCm39) missense probably benign 0.01
R4832:Mob4 UTSW 1 55,184,411 (GRCm39) intron probably benign
R4876:Mob4 UTSW 1 55,191,995 (GRCm39) unclassified probably benign
R4972:Mob4 UTSW 1 55,190,161 (GRCm39) missense possibly damaging 0.96
R5747:Mob4 UTSW 1 55,187,737 (GRCm39) missense probably damaging 1.00
R6774:Mob4 UTSW 1 55,187,588 (GRCm39) splice site probably null
R6925:Mob4 UTSW 1 55,191,881 (GRCm39) nonsense probably null
R7447:Mob4 UTSW 1 55,170,625 (GRCm39) start gained probably benign
R7721:Mob4 UTSW 1 55,187,479 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCTTCAGCGCAACTTTTATGAG -3'
(R):5'- ACATCTCTGCTTTCACATAGAGG -3'

Sequencing Primer
(F):5'- CTTTCCAGTTAAACAGTCCATGAAAG -3'
(R):5'- TCAAAAATGCTATCAAAGGTACAGC -3'
Posted On 2018-08-01