Incidental Mutation 'R6717:Fry'
ID 529429
Institutional Source Beutler Lab
Gene Symbol Fry
Ensembl Gene ENSMUSG00000056602
Gene Name FRY microtubule binding protein
Synonyms 9330186A19Rik, cg003
MMRRC Submission 044835-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.585) question?
Stock # R6717 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 150118645-150497753 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 150496312 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 980 (T980A)
Ref Sequence ENSEMBL: ENSMUSP00000144657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087204] [ENSMUST00000202566]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000087204
AA Change: T2984A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000084454
Gene: ENSMUSG00000056602
AA Change: T2984A

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_N 165 697 5.3e-170 PFAM
low complexity region 1014 1040 N/A INTRINSIC
Pfam:MOR2-PAG1_mid 1188 1380 1.2e-15 PFAM
Pfam:MOR2-PAG1_mid 1398 1534 1.5e-5 PFAM
Pfam:MOR2-PAG1_mid 1632 1704 1.8e-7 PFAM
Pfam:MOR2-PAG1_mid 1772 1906 4.9e-10 PFAM
low complexity region 1936 1956 N/A INTRINSIC
low complexity region 1962 1980 N/A INTRINSIC
Pfam:MOR2-PAG1_C 2050 2303 1.9e-74 PFAM
low complexity region 2369 2385 N/A INTRINSIC
low complexity region 2463 2482 N/A INTRINSIC
low complexity region 2525 2534 N/A INTRINSIC
low complexity region 2836 2852 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000200863
AA Change: T616A
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201196
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201628
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202066
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202386
Predicted Effect probably benign
Transcript: ENSMUST00000202566
AA Change: T980A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000144657
Gene: ENSMUSG00000056602
AA Change: T980A

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_C 37 290 1.5e-71 PFAM
low complexity region 356 372 N/A INTRINSIC
low complexity region 447 472 N/A INTRINSIC
low complexity region 515 524 N/A INTRINSIC
low complexity region 832 848 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202571
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 C T 5: 4,064,086 (GRCm38) L3122F probably damaging Het
Atp6v1b1 A T 6: 83,753,650 (GRCm38) probably null Het
Ccdc178 A T 18: 22,020,889 (GRCm38) V621E probably damaging Het
Cfap126 T C 1: 171,114,102 (GRCm38) probably null Het
Cog2 T C 8: 124,525,749 (GRCm38) I64T probably damaging Het
Dhx9 A C 1: 153,473,464 (GRCm38) probably null Het
Efcab7 A G 4: 99,904,734 (GRCm38) D407G possibly damaging Het
Eif2b5 G T 16: 20,505,283 (GRCm38) G459C probably damaging Het
Eml5 T C 12: 98,827,506 (GRCm38) E1168G probably damaging Het
Flnc AGCTGTCAAGTATGCTG AGCTG 6: 29,450,902 (GRCm38) probably benign Het
Gabbr2 A G 4: 46,787,574 (GRCm38) V363A possibly damaging Het
Ggt6 T A 11: 72,437,520 (GRCm38) L244* probably null Het
Gm13119 G T 4: 144,362,657 (GRCm38) V182L probably benign Het
Gprc6a T A 10: 51,615,137 (GRCm38) I768F probably damaging Het
Grk1 G A 8: 13,416,237 (GRCm38) M560I probably benign Het
Hapln4 G A 8: 70,085,090 (GRCm38) E145K probably damaging Het
Hoxd9 C T 2: 74,698,389 (GRCm38) P112S probably benign Het
Ly6g6f T A 17: 35,085,574 (GRCm38) M1L probably benign Het
Mast1 T C 8: 84,917,754 (GRCm38) T849A probably benign Het
Mob4 A T 1: 55,136,713 (GRCm38) M39L possibly damaging Het
Mrgpre A T 7: 143,781,523 (GRCm38) L81Q probably damaging Het
Mst1 T C 9: 108,080,575 (GRCm38) probably null Het
Muc5b A T 7: 141,857,822 (GRCm38) R1502* probably null Het
Olfr1020 T A 2: 85,850,223 (GRCm38) I257N probably damaging Het
Olfr142 T A 2: 90,252,524 (GRCm38) I155L probably benign Het
Olfr311 T C 11: 58,841,287 (GRCm38) Y58H probably damaging Het
Pdc A G 1: 150,333,018 (GRCm38) D84G probably damaging Het
Peak1 T C 9: 56,207,239 (GRCm38) N443D probably benign Het
Pkd1l3 T A 8: 109,614,769 (GRCm38) W85R unknown Het
Rfc1 A G 5: 65,312,961 (GRCm38) S68P probably damaging Het
Rfc1 G A 5: 65,302,004 (GRCm38) Q190* probably null Het
Rnf145 T C 11: 44,561,490 (GRCm38) V432A probably benign Het
Ror2 A G 13: 53,118,982 (GRCm38) S204P probably damaging Het
Scn1a T C 2: 66,332,287 (GRCm38) E205G probably damaging Het
Slc2a8 A C 2: 32,976,177 (GRCm38) M277R probably damaging Het
Slc4a1 T C 11: 102,354,423 (GRCm38) Y566C probably damaging Het
Slc6a12 A G 6: 121,354,303 (GRCm38) N185S probably benign Het
Srcap GCTCCTCCTCCTCCTCCT GCTCCTCCTCCTCCT 7: 127,558,310 (GRCm38) probably benign Het
Stk33 T A 7: 109,327,616 (GRCm38) T279S possibly damaging Het
Taok3 A G 5: 117,240,950 (GRCm38) probably benign Het
Tlr11 A G 14: 50,362,104 (GRCm38) T516A probably benign Het
Tmem132c T A 5: 127,564,029 (GRCm38) L1088Q possibly damaging Het
Tmem132d T A 5: 127,784,421 (GRCm38) M879L probably benign Het
Tnk2 A G 16: 32,670,869 (GRCm38) E322G probably damaging Het
Ttc28 T C 5: 111,285,436 (GRCm38) V2081A probably benign Het
Ttn C T 2: 76,794,409 (GRCm38) probably null Het
Zfp105 T C 9: 122,930,308 (GRCm38) V348A possibly damaging Het
Zswim2 T C 2: 83,915,409 (GRCm38) R562G probably benign Het
Other mutations in Fry
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Fry APN 5 150,340,404 (GRCm38) nonsense probably null
IGL00328:Fry APN 5 150,340,404 (GRCm38) nonsense probably null
IGL00841:Fry APN 5 150,422,724 (GRCm38) missense probably benign
IGL00938:Fry APN 5 150,370,180 (GRCm38) missense probably damaging 1.00
IGL01015:Fry APN 5 150,422,787 (GRCm38) missense probably benign 0.18
IGL01401:Fry APN 5 150,438,788 (GRCm38) missense probably benign
IGL01616:Fry APN 5 150,399,599 (GRCm38) missense probably damaging 1.00
IGL01616:Fry APN 5 150,438,811 (GRCm38) splice site probably null
IGL01748:Fry APN 5 150,345,651 (GRCm38) splice site probably benign
IGL01965:Fry APN 5 150,381,621 (GRCm38) missense probably damaging 1.00
IGL02030:Fry APN 5 150,471,618 (GRCm38) splice site probably benign
IGL02079:Fry APN 5 150,399,624 (GRCm38) missense probably damaging 0.97
IGL02087:Fry APN 5 150,403,594 (GRCm38) missense probably benign 0.23
IGL02113:Fry APN 5 150,399,605 (GRCm38) missense probably benign
IGL02209:Fry APN 5 150,437,026 (GRCm38) missense probably benign 0.00
IGL02250:Fry APN 5 150,403,434 (GRCm38) splice site probably benign
IGL02265:Fry APN 5 150,437,153 (GRCm38) missense probably damaging 1.00
IGL02486:Fry APN 5 150,491,177 (GRCm38) missense probably damaging 0.99
IGL02552:Fry APN 5 150,380,910 (GRCm38) missense probably damaging 1.00
IGL02881:Fry APN 5 150,359,051 (GRCm38) missense probably damaging 0.99
IGL03008:Fry APN 5 150,345,556 (GRCm38) missense possibly damaging 0.82
IGL03140:Fry APN 5 150,495,701 (GRCm38) missense probably damaging 0.98
IGL03171:Fry APN 5 150,380,809 (GRCm38) missense probably damaging 1.00
IGL03389:Fry APN 5 150,394,231 (GRCm38) missense probably damaging 1.00
IGL03404:Fry APN 5 150,326,168 (GRCm38) missense probably damaging 1.00
Brook UTSW 5 150,326,132 (GRCm38) missense probably damaging 1.00
haydn UTSW 5 150,418,464 (GRCm38) missense possibly damaging 0.94
miracle UTSW 5 150,437,159 (GRCm38) missense probably damaging 0.99
quickening UTSW 5 150,434,776 (GRCm38) missense probably damaging 1.00
seasons UTSW 5 150,466,437 (GRCm38) missense probably benign 0.06
Vivaldi UTSW 5 150,394,138 (GRCm38) missense possibly damaging 0.80
R0023:Fry UTSW 5 150,451,098 (GRCm38) missense possibly damaging 0.78
R0024:Fry UTSW 5 150,380,803 (GRCm38) missense probably benign 0.03
R0030:Fry UTSW 5 150,372,569 (GRCm38) nonsense probably null
R0053:Fry UTSW 5 150,461,377 (GRCm38) splice site probably benign
R0089:Fry UTSW 5 150,340,427 (GRCm38) missense possibly damaging 0.91
R0212:Fry UTSW 5 150,496,397 (GRCm38) missense probably damaging 0.99
R0241:Fry UTSW 5 150,260,346 (GRCm38) intron probably benign
R0265:Fry UTSW 5 150,434,776 (GRCm38) missense probably damaging 1.00
R0317:Fry UTSW 5 150,471,468 (GRCm38) missense probably damaging 1.00
R0532:Fry UTSW 5 150,478,761 (GRCm38) splice site probably benign
R0532:Fry UTSW 5 150,433,707 (GRCm38) unclassified probably benign
R0599:Fry UTSW 5 150,437,159 (GRCm38) missense probably damaging 0.99
R0631:Fry UTSW 5 150,496,352 (GRCm38) missense possibly damaging 0.82
R0723:Fry UTSW 5 150,496,360 (GRCm38) missense probably damaging 1.00
R0766:Fry UTSW 5 150,403,432 (GRCm38) splice site probably benign
R0790:Fry UTSW 5 150,466,437 (GRCm38) missense probably benign 0.06
R0928:Fry UTSW 5 150,437,084 (GRCm38) missense probably damaging 1.00
R1104:Fry UTSW 5 150,496,289 (GRCm38) missense probably damaging 1.00
R1144:Fry UTSW 5 150,418,464 (GRCm38) missense possibly damaging 0.94
R1172:Fry UTSW 5 150,481,494 (GRCm38) nonsense probably null
R1312:Fry UTSW 5 150,403,432 (GRCm38) splice site probably benign
R1347:Fry UTSW 5 150,495,818 (GRCm38) missense probably damaging 1.00
R1347:Fry UTSW 5 150,495,818 (GRCm38) missense probably damaging 1.00
R1437:Fry UTSW 5 150,310,425 (GRCm38) missense possibly damaging 0.92
R1458:Fry UTSW 5 150,380,859 (GRCm38) missense probably damaging 1.00
R1542:Fry UTSW 5 150,404,966 (GRCm38) missense probably benign 0.13
R1692:Fry UTSW 5 150,370,227 (GRCm38) missense probably damaging 1.00
R1826:Fry UTSW 5 150,436,709 (GRCm38) missense possibly damaging 0.82
R1874:Fry UTSW 5 150,345,921 (GRCm38) missense probably damaging 1.00
R1875:Fry UTSW 5 150,326,132 (GRCm38) missense probably damaging 1.00
R1881:Fry UTSW 5 150,478,046 (GRCm38) missense probably damaging 0.97
R1884:Fry UTSW 5 150,403,520 (GRCm38) missense probably benign 0.00
R1929:Fry UTSW 5 150,400,924 (GRCm38) missense probably null 0.02
R2066:Fry UTSW 5 150,370,119 (GRCm38) splice site probably benign
R2270:Fry UTSW 5 150,400,924 (GRCm38) missense probably null 0.02
R2356:Fry UTSW 5 150,471,432 (GRCm38) missense probably benign
R3720:Fry UTSW 5 150,454,572 (GRCm38) missense probably damaging 1.00
R3773:Fry UTSW 5 150,398,198 (GRCm38) missense probably damaging 0.96
R3824:Fry UTSW 5 150,496,419 (GRCm38) missense possibly damaging 0.94
R3902:Fry UTSW 5 150,345,927 (GRCm38) missense probably damaging 1.00
R3923:Fry UTSW 5 150,413,349 (GRCm38) missense probably benign
R4250:Fry UTSW 5 150,310,360 (GRCm38) missense probably damaging 0.99
R4332:Fry UTSW 5 150,381,663 (GRCm38) missense probably damaging 1.00
R4495:Fry UTSW 5 150,310,463 (GRCm38) missense probably damaging 1.00
R4610:Fry UTSW 5 150,386,104 (GRCm38) missense probably damaging 1.00
R4682:Fry UTSW 5 150,422,754 (GRCm38) missense probably damaging 1.00
R4732:Fry UTSW 5 150,386,007 (GRCm38) missense
R4733:Fry UTSW 5 150,386,007 (GRCm38) missense
R4755:Fry UTSW 5 150,398,254 (GRCm38) missense probably damaging 0.99
R4788:Fry UTSW 5 150,399,636 (GRCm38) missense probably benign 0.00
R4803:Fry UTSW 5 150,399,533 (GRCm38) missense probably benign 0.31
R4858:Fry UTSW 5 150,401,643 (GRCm38) missense possibly damaging 0.78
R4872:Fry UTSW 5 150,394,239 (GRCm38) critical splice donor site probably null
R4902:Fry UTSW 5 150,495,703 (GRCm38) missense probably benign 0.43
R4915:Fry UTSW 5 150,478,863 (GRCm38) missense probably benign 0.30
R4938:Fry UTSW 5 150,477,989 (GRCm38) missense probably damaging 1.00
R4983:Fry UTSW 5 150,398,254 (GRCm38) missense probably damaging 1.00
R5004:Fry UTSW 5 150,433,604 (GRCm38) missense probably benign 0.16
R5040:Fry UTSW 5 150,388,854 (GRCm38) missense probably damaging 0.99
R5145:Fry UTSW 5 150,370,224 (GRCm38) missense probably damaging 0.98
R5170:Fry UTSW 5 150,429,854 (GRCm38) missense probably benign 0.03
R5233:Fry UTSW 5 150,469,720 (GRCm38) missense possibly damaging 0.71
R5428:Fry UTSW 5 150,405,359 (GRCm38) missense possibly damaging 0.89
R5468:Fry UTSW 5 150,399,588 (GRCm38) missense probably benign 0.44
R5481:Fry UTSW 5 150,260,319 (GRCm38) missense probably benign 0.01
R5494:Fry UTSW 5 150,390,667 (GRCm38) missense probably damaging 1.00
R5538:Fry UTSW 5 150,495,848 (GRCm38) missense probably damaging 1.00
R5638:Fry UTSW 5 150,359,081 (GRCm38) missense possibly damaging 0.46
R5645:Fry UTSW 5 150,380,867 (GRCm38) missense probably damaging 1.00
R5716:Fry UTSW 5 150,370,221 (GRCm38) nonsense probably null
R5812:Fry UTSW 5 150,399,671 (GRCm38) missense probably damaging 0.99
R5813:Fry UTSW 5 150,399,671 (GRCm38) missense probably damaging 0.99
R5873:Fry UTSW 5 150,378,885 (GRCm38) missense probably damaging 1.00
R5933:Fry UTSW 5 150,390,800 (GRCm38) intron probably benign
R6037:Fry UTSW 5 150,428,179 (GRCm38) missense probably benign 0.03
R6037:Fry UTSW 5 150,428,179 (GRCm38) missense probably benign 0.03
R6158:Fry UTSW 5 150,454,572 (GRCm38) missense probably damaging 1.00
R6178:Fry UTSW 5 150,454,522 (GRCm38) missense probably damaging 1.00
R6481:Fry UTSW 5 150,386,014 (GRCm38) missense probably damaging 1.00
R6562:Fry UTSW 5 150,326,149 (GRCm38) missense probably damaging 1.00
R6676:Fry UTSW 5 150,380,922 (GRCm38) missense probably benign 0.22
R6828:Fry UTSW 5 150,466,446 (GRCm38) splice site probably null
R6874:Fry UTSW 5 150,437,303 (GRCm38) missense probably benign 0.00
R6930:Fry UTSW 5 150,428,230 (GRCm38) missense probably benign 0.00
R6963:Fry UTSW 5 150,457,844 (GRCm38) missense probably benign 0.17
R6965:Fry UTSW 5 150,416,220 (GRCm38) missense possibly damaging 0.79
R7051:Fry UTSW 5 150,395,169 (GRCm38) missense possibly damaging 0.93
R7085:Fry UTSW 5 150,438,749 (GRCm38) missense probably benign 0.02
R7108:Fry UTSW 5 150,491,090 (GRCm38) missense
R7108:Fry UTSW 5 150,395,786 (GRCm38) missense probably damaging 1.00
R7115:Fry UTSW 5 150,386,067 (GRCm38) missense probably damaging 1.00
R7116:Fry UTSW 5 150,395,869 (GRCm38) critical splice donor site probably null
R7197:Fry UTSW 5 150,469,767 (GRCm38) missense
R7256:Fry UTSW 5 150,466,786 (GRCm38) missense
R7318:Fry UTSW 5 150,436,993 (GRCm38) missense probably damaging 0.98
R7323:Fry UTSW 5 150,496,349 (GRCm38) missense
R7358:Fry UTSW 5 150,416,323 (GRCm38) missense probably benign
R7361:Fry UTSW 5 150,436,847 (GRCm38) missense possibly damaging 0.92
R7395:Fry UTSW 5 150,380,883 (GRCm38) missense possibly damaging 0.82
R7487:Fry UTSW 5 150,414,574 (GRCm38) missense possibly damaging 0.79
R7491:Fry UTSW 5 150,466,326 (GRCm38) missense
R7574:Fry UTSW 5 150,380,894 (GRCm38) missense probably benign 0.00
R7582:Fry UTSW 5 150,496,382 (GRCm38) missense
R7586:Fry UTSW 5 150,426,218 (GRCm38) missense probably damaging 1.00
R7650:Fry UTSW 5 150,413,418 (GRCm38) missense probably damaging 1.00
R7699:Fry UTSW 5 150,405,327 (GRCm38) missense probably damaging 0.98
R7700:Fry UTSW 5 150,405,327 (GRCm38) missense probably damaging 0.98
R7972:Fry UTSW 5 150,310,396 (GRCm38) missense probably benign 0.05
R8058:Fry UTSW 5 150,495,767 (GRCm38) missense
R8070:Fry UTSW 5 150,478,007 (GRCm38) missense
R8159:Fry UTSW 5 150,399,533 (GRCm38) missense probably benign 0.31
R8202:Fry UTSW 5 150,431,737 (GRCm38) missense probably damaging 1.00
R8261:Fry UTSW 5 150,445,907 (GRCm38) missense probably damaging 1.00
R8279:Fry UTSW 5 150,496,261 (GRCm38) missense
R8338:Fry UTSW 5 150,359,051 (GRCm38) missense probably damaging 0.99
R8370:Fry UTSW 5 150,395,819 (GRCm38) missense probably damaging 1.00
R8673:Fry UTSW 5 150,395,111 (GRCm38) missense possibly damaging 0.91
R8786:Fry UTSW 5 150,394,036 (GRCm38) missense probably benign 0.00
R8815:Fry UTSW 5 150,394,138 (GRCm38) missense possibly damaging 0.80
R8847:Fry UTSW 5 150,386,007 (GRCm38) missense
R9023:Fry UTSW 5 150,437,303 (GRCm38) missense probably benign 0.00
R9025:Fry UTSW 5 150,295,808 (GRCm38) intron probably benign
R9125:Fry UTSW 5 150,346,060 (GRCm38) missense probably damaging 0.97
R9172:Fry UTSW 5 150,413,328 (GRCm38) missense probably benign
R9262:Fry UTSW 5 150,381,644 (GRCm38) missense probably damaging 1.00
R9263:Fry UTSW 5 150,399,263 (GRCm38) missense probably damaging 1.00
R9293:Fry UTSW 5 150,495,832 (GRCm38) missense
R9368:Fry UTSW 5 150,477,938 (GRCm38) missense
R9401:Fry UTSW 5 150,378,938 (GRCm38) missense probably damaging 1.00
R9402:Fry UTSW 5 150,436,853 (GRCm38) missense probably damaging 1.00
R9402:Fry UTSW 5 150,433,696 (GRCm38) missense possibly damaging 0.91
R9420:Fry UTSW 5 150,433,529 (GRCm38) missense possibly damaging 0.72
R9557:Fry UTSW 5 150,466,316 (GRCm38) missense
R9647:Fry UTSW 5 150,369,519 (GRCm38) missense probably damaging 1.00
R9650:Fry UTSW 5 150,445,910 (GRCm38) missense probably damaging 1.00
R9655:Fry UTSW 5 150,438,786 (GRCm38) missense possibly damaging 0.90
R9664:Fry UTSW 5 150,359,023 (GRCm38) missense probably damaging 0.98
R9668:Fry UTSW 5 150,358,853 (GRCm38) missense probably damaging 1.00
R9732:Fry UTSW 5 150,405,293 (GRCm38) missense probably benign 0.00
R9773:Fry UTSW 5 150,399,263 (GRCm38) missense probably damaging 1.00
Z1177:Fry UTSW 5 150,310,437 (GRCm38) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GACTCATACTTCCCAACTCCATG -3'
(R):5'- CGAAGGCCGAGAAGACACT -3'

Sequencing Primer
(F):5'- AACTCCATGCCTCTAAATCTTTGTTG -3'
(R):5'- ACACTGAAGGAGGTCGCC -3'
Posted On 2018-08-01