Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01118:Yeats2'

52944

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Yeats2

Ensembl Gene

ENSMUSG00000041215

Gene Name

YEATS domain containing 2

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.964) question?

Stock #

IGL01118

Quality Score

Status

Chromosome

Chromosomal Location

19959813-20051323 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 20005054 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 364 (S364A)

Ref Sequence

ENSEMBL: ENSMUSP00000155892 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]

AlphaFold

Q3TUF7

Predicted Effect

probably damaging
Transcript: ENSMUST00000090052
AA Change: S348A

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215
AA Change: S348A

Domain	Start	End	E-Value	Type
Pfam:YEATS	179	262	2.6e-27	PFAM
low complexity region	299	309	N/A	INTRINSIC
low complexity region	312	333	N/A	INTRINSIC
low complexity region	409	429	N/A	INTRINSIC
low complexity region	458	467	N/A	INTRINSIC
internal_repeat_1	471	675	3.72e-6	PROSPERO
low complexity region	683	702	N/A	INTRINSIC
low complexity region	738	775	N/A	INTRINSIC
internal_repeat_1	785	978	3.72e-6	PROSPERO
low complexity region	1240	1249	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000115560
AA Change: S401A

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215
AA Change: S401A

Domain	Start	End	E-Value	Type
Pfam:YEATS	232	314	2.1e-28	PFAM
low complexity region	352	362	N/A	INTRINSIC
low complexity region	365	386	N/A	INTRINSIC
low complexity region	462	482	N/A	INTRINSIC
low complexity region	511	520	N/A	INTRINSIC
internal_repeat_1	524	728	4.68e-6	PROSPERO
low complexity region	736	755	N/A	INTRINSIC
low complexity region	791	828	N/A	INTRINSIC
internal_repeat_1	838	1031	4.68e-6	PROSPERO
low complexity region	1293	1302	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231861

Predicted Effect

probably damaging
Transcript: ENSMUST00000232019
AA Change: S364A

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232172

Predicted Effect

possibly damaging
Transcript: ENSMUST00000232338
AA Change: S345A

PolyPhen 2 Score 0.855 (Sensitivity: 0.83; Specificity: 0.93)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	C	T	3: 124,195,058 (GRCm39)	R539Q	probably benign	Het
Abcb1a	G	A	5: 8,724,687 (GRCm39)	R40H	probably damaging	Het
Acan	T	A	7: 78,748,401 (GRCm39)	S1057R	possibly damaging	Het
Ahnak	A	T	19: 8,989,942 (GRCm39)	D3742V	probably damaging	Het
Amdhd1	A	T	10: 93,367,430 (GRCm39)	D241E	probably benign	Het
Cntn5	T	C	9: 9,831,565 (GRCm39)	Y605C	possibly damaging	Het
Dnmt3l	T	C	10: 77,893,120 (GRCm39)	F299S	probably damaging	Het
Eif1ad19	T	A	12: 87,740,212 (GRCm39)	N116Y	probably damaging	Het
Ess2	A	T	16: 17,720,796 (GRCm39)	I350N	probably damaging	Het
G6pd2	A	T	5: 61,967,406 (GRCm39)	M394L	probably benign	Het
Gm9839	A	T	1: 32,558,924 (GRCm39)	M386K	probably benign	Het
Gtf2h3	T	C	5: 124,733,731 (GRCm39)	V268A	probably damaging	Het
Hgs	T	C	11: 120,366,040 (GRCm39)	V195A	probably damaging	Het
Igkv3-2	A	T	6: 70,675,978 (GRCm39)	S96C	probably damaging	Het
Mgl2	A	G	11: 70,025,015 (GRCm39)	E12G	probably benign	Het
Mup11	A	T	4: 60,615,779 (GRCm39)	F153I	probably damaging	Het
Nf1	T	A	11: 79,437,812 (GRCm39)	C2057S	probably damaging	Het
Nkrf	A	G	X: 36,152,410 (GRCm39)	F624S	probably damaging	Het
Noto	T	C	6: 85,401,192 (GRCm39)	S74P	probably benign	Het
Or8k40	A	G	2: 86,584,314 (GRCm39)	I256T	probably benign	Het
Pax8	T	C	2: 24,332,944 (GRCm39)		probably benign	Het
Psg28	A	T	7: 18,162,017 (GRCm39)	V162D	probably damaging	Het
Rai1	T	C	11: 60,078,264 (GRCm39)	F776S	probably damaging	Het
Taar8a	A	T	10: 23,952,759 (GRCm39)	H121L	probably damaging	Het
Tas2r113	A	G	6: 132,870,278 (GRCm39)	N102S	probably benign	Het
Trpm1	A	G	7: 63,885,572 (GRCm39)	T863A	probably benign	Het
Ttf2	A	G	3: 100,874,413 (GRCm39)		probably benign	Het
Wdr62	T	C	7: 29,942,206 (GRCm39)	H611R	probably damaging	Het
Wdr90	A	T	17: 26,073,661 (GRCm39)	L762Q	probably damaging	Het
Zdhhc15	G	T	X: 103,641,712 (GRCm39)	Q82K	probably benign	Het

Other mutations in Yeats2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01128:Yeats2	APN	16	19,980,718 (GRCm39)	splice site	probably benign
IGL01139:Yeats2	APN	16	20,033,143 (GRCm39)	missense	probably damaging	1.00
IGL01394:Yeats2	APN	16	19,980,782 (GRCm39)	missense	probably damaging	0.99
IGL01482:Yeats2	APN	16	20,041,671 (GRCm39)	missense	probably damaging	1.00
IGL01924:Yeats2	APN	16	20,024,917 (GRCm39)	missense	probably damaging	1.00
IGL01925:Yeats2	APN	16	19,998,430 (GRCm39)	splice site	probably benign
IGL02106:Yeats2	APN	16	20,011,970 (GRCm39)	missense	possibly damaging	0.79
IGL02370:Yeats2	APN	16	19,969,221 (GRCm39)	missense	probably damaging	0.99
IGL02447:Yeats2	APN	16	20,012,429 (GRCm39)	missense	probably benign	0.00
IGL02669:Yeats2	APN	16	20,005,033 (GRCm39)	missense	probably benign	0.13
IGL03155:Yeats2	APN	16	20,048,323 (GRCm39)	critical splice donor site	probably null
tyrion	UTSW	16	20,032,151 (GRCm39)	splice site	probably benign
P0045:Yeats2	UTSW	16	19,975,695 (GRCm39)	missense	possibly damaging	0.47
R0051:Yeats2	UTSW	16	20,012,474 (GRCm39)	nonsense	probably null
R0051:Yeats2	UTSW	16	20,012,474 (GRCm39)	nonsense	probably null
R0118:Yeats2	UTSW	16	19,975,692 (GRCm39)	nonsense	probably null
R0157:Yeats2	UTSW	16	20,040,427 (GRCm39)	makesense	probably null
R0184:Yeats2	UTSW	16	20,022,435 (GRCm39)	missense	possibly damaging	0.79
R0194:Yeats2	UTSW	16	19,971,719 (GRCm39)	start codon destroyed	probably null	1.00
R0612:Yeats2	UTSW	16	20,005,175 (GRCm39)	missense	probably benign	0.00
R0655:Yeats2	UTSW	16	20,012,574 (GRCm39)	nonsense	probably null
R0826:Yeats2	UTSW	16	20,011,966 (GRCm39)	nonsense	probably null
R1526:Yeats2	UTSW	16	20,024,836 (GRCm39)	missense	probably damaging	1.00
R1535:Yeats2	UTSW	16	20,008,115 (GRCm39)	missense	probably damaging	0.99
R1749:Yeats2	UTSW	16	20,005,018 (GRCm39)	nonsense	probably null
R1842:Yeats2	UTSW	16	19,989,988 (GRCm39)	missense	probably damaging	1.00
R1843:Yeats2	UTSW	16	20,048,314 (GRCm39)	missense	probably benign	0.01
R1926:Yeats2	UTSW	16	20,033,176 (GRCm39)	missense	probably benign
R2000:Yeats2	UTSW	16	20,005,141 (GRCm39)	missense	probably benign	0.20
R2017:Yeats2	UTSW	16	19,977,931 (GRCm39)	missense	probably benign	0.01
R2076:Yeats2	UTSW	16	20,005,032 (GRCm39)	missense	possibly damaging	0.47
R2153:Yeats2	UTSW	16	19,972,916 (GRCm39)	missense	probably damaging	1.00
R2167:Yeats2	UTSW	16	20,032,151 (GRCm39)	splice site	probably benign
R2981:Yeats2	UTSW	16	20,005,051 (GRCm39)	missense	probably damaging	0.99
R3160:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3161:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3162:Yeats2	UTSW	16	20,012,395 (GRCm39)	missense	probably damaging	1.00
R3774:Yeats2	UTSW	16	19,969,245 (GRCm39)	missense	probably damaging	1.00
R4250:Yeats2	UTSW	16	19,975,685 (GRCm39)	missense	possibly damaging	0.90
R4305:Yeats2	UTSW	16	20,027,172 (GRCm39)	missense	probably damaging	1.00
R4455:Yeats2	UTSW	16	19,980,743 (GRCm39)	missense	possibly damaging	0.88
R4458:Yeats2	UTSW	16	20,032,071 (GRCm39)	missense	probably damaging	0.99
R4811:Yeats2	UTSW	16	19,971,645 (GRCm39)	splice site	probably null
R4902:Yeats2	UTSW	16	20,026,418 (GRCm39)	missense	probably benign	0.00
R5043:Yeats2	UTSW	16	20,027,215 (GRCm39)	missense	probably damaging	1.00
R5047:Yeats2	UTSW	16	20,027,215 (GRCm39)	missense	probably damaging	1.00
R5319:Yeats2	UTSW	16	20,005,175 (GRCm39)	missense	probably benign	0.01
R5328:Yeats2	UTSW	16	19,989,955 (GRCm39)	missense	probably damaging	1.00
R5360:Yeats2	UTSW	16	19,972,912 (GRCm39)	missense	probably damaging	0.97
R5416:Yeats2	UTSW	16	20,030,319 (GRCm39)	missense	probably benign	0.01
R5672:Yeats2	UTSW	16	19,980,779 (GRCm39)	missense	probably damaging	1.00
R5684:Yeats2	UTSW	16	20,012,553 (GRCm39)	missense	possibly damaging	0.94
R5932:Yeats2	UTSW	16	20,011,913 (GRCm39)	missense	probably benign	0.06
R5946:Yeats2	UTSW	16	20,026,513 (GRCm39)	nonsense	probably null
R6168:Yeats2	UTSW	16	19,998,308 (GRCm39)	missense	probably benign	0.01
R6169:Yeats2	UTSW	16	20,038,417 (GRCm39)	missense	probably damaging	1.00
R6179:Yeats2	UTSW	16	20,033,225 (GRCm39)	missense	probably benign	0.16
R6371:Yeats2	UTSW	16	20,040,460 (GRCm39)	missense	possibly damaging	0.54
R6877:Yeats2	UTSW	16	19,998,344 (GRCm39)	missense	probably benign	0.00
R7149:Yeats2	UTSW	16	19,972,939 (GRCm39)	missense	probably damaging	1.00
R7405:Yeats2	UTSW	16	20,041,663 (GRCm39)	missense	probably damaging	1.00
R8353:Yeats2	UTSW	16	20,041,637 (GRCm39)	nonsense	probably null
R8367:Yeats2	UTSW	16	20,041,575 (GRCm39)	missense	probably damaging	1.00
R8453:Yeats2	UTSW	16	20,041,637 (GRCm39)	nonsense	probably null
R8506:Yeats2	UTSW	16	19,971,684 (GRCm39)	missense	probably damaging	0.98
R8535:Yeats2	UTSW	16	19,977,926 (GRCm39)	missense	probably damaging	1.00
R8828:Yeats2	UTSW	16	19,969,260 (GRCm39)	missense	probably benign	0.45
R8905:Yeats2	UTSW	16	20,009,144 (GRCm39)	missense	probably benign	0.02
R8924:Yeats2	UTSW	16	19,969,312 (GRCm39)	critical splice donor site	probably null
R9087:Yeats2	UTSW	16	20,030,500 (GRCm39)	critical splice donor site	probably null
R9276:Yeats2	UTSW	16	19,975,786 (GRCm39)	missense	probably benign	0.34
R9338:Yeats2	UTSW	16	20,041,533 (GRCm39)	missense	probably damaging	0.99
R9338:Yeats2	UTSW	16	20,032,078 (GRCm39)	missense	possibly damaging	0.69
R9378:Yeats2	UTSW	16	20,033,228 (GRCm39)	missense	probably benign
R9569:Yeats2	UTSW	16	19,972,902 (GRCm39)	missense	probably damaging	1.00
R9664:Yeats2	UTSW	16	20,047,491 (GRCm39)	nonsense	probably null

Posted On

2013-06-21