Incidental Mutation 'R6717:Zfp105'
ID 529443
Institutional Source Beutler Lab
Gene Symbol Zfp105
Ensembl Gene ENSMUSG00000057895
Gene Name zinc finger protein 105
Synonyms
MMRRC Submission 044835-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.140) question?
Stock # R6717 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 122752137-122760093 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 122759373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 348 (V348A)
Ref Sequence ENSEMBL: ENSMUSP00000079840 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051667] [ENSMUST00000148851]
AlphaFold G3X9I0
Predicted Effect possibly damaging
Transcript: ENSMUST00000051667
AA Change: V348A

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000079840
Gene: ENSMUSG00000057895
AA Change: V348A

DomainStartEndE-ValueType
ZnF_C2H2 219 241 4.54e-4 SMART
ZnF_C2H2 247 269 1.69e-3 SMART
ZnF_C2H2 275 297 1.2e-3 SMART
ZnF_C2H2 303 325 7.9e-4 SMART
ZnF_C2H2 331 353 7.49e-5 SMART
ZnF_C2H2 359 381 1.82e-3 SMART
ZnF_C2H2 387 409 5.42e-2 SMART
ZnF_C2H2 415 437 2.95e-3 SMART
ZnF_C2H2 443 465 4.79e-3 SMART
ZnF_C2H2 471 493 9.22e-5 SMART
ZnF_C2H2 499 521 1.92e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148851
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 98% (47/48)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trapped allele display abnormal spermatogenesis and reduced male fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 C T 5: 4,114,086 (GRCm39) L3122F probably damaging Het
Atp6v1b1 A T 6: 83,730,632 (GRCm39) probably null Het
Ccdc178 A T 18: 22,153,946 (GRCm39) V621E probably damaging Het
Cfap126 T C 1: 170,941,671 (GRCm39) probably null Het
Cog2 T C 8: 125,252,488 (GRCm39) I64T probably damaging Het
Dhx9 A C 1: 153,349,210 (GRCm39) probably null Het
Efcab7 A G 4: 99,761,931 (GRCm39) D407G possibly damaging Het
Eif2b5 G T 16: 20,324,033 (GRCm39) G459C probably damaging Het
Eml5 T C 12: 98,793,765 (GRCm39) E1168G probably damaging Het
Flnc AGCTGTCAAGTATGCTG AGCTG 6: 29,450,901 (GRCm39) probably benign Het
Fry A G 5: 150,419,777 (GRCm39) T980A probably benign Het
Gabbr2 A G 4: 46,787,574 (GRCm39) V363A possibly damaging Het
Ggt6 T A 11: 72,328,346 (GRCm39) L244* probably null Het
Gprc6a T A 10: 51,491,233 (GRCm39) I768F probably damaging Het
Grk1 G A 8: 13,466,237 (GRCm39) M560I probably benign Het
Hapln4 G A 8: 70,537,740 (GRCm39) E145K probably damaging Het
Hoxd9 C T 2: 74,528,733 (GRCm39) P112S probably benign Het
Ly6g6f T A 17: 35,304,550 (GRCm39) M1L probably benign Het
Mast1 T C 8: 85,644,383 (GRCm39) T849A probably benign Het
Mob4 A T 1: 55,175,872 (GRCm39) M39L possibly damaging Het
Mrgpre A T 7: 143,335,260 (GRCm39) L81Q probably damaging Het
Mst1 T C 9: 107,957,774 (GRCm39) probably null Het
Muc5b A T 7: 141,411,559 (GRCm39) R1502* probably null Het
Or4b13 T A 2: 90,082,868 (GRCm39) I155L probably benign Het
Or5ap2 T A 2: 85,680,567 (GRCm39) I257N probably damaging Het
Or9e1 T C 11: 58,732,113 (GRCm39) Y58H probably damaging Het
Pdc A G 1: 150,208,769 (GRCm39) D84G probably damaging Het
Peak1 T C 9: 56,114,523 (GRCm39) N443D probably benign Het
Pkd1l3 T A 8: 110,341,401 (GRCm39) W85R unknown Het
Pramel31 G T 4: 144,089,227 (GRCm39) V182L probably benign Het
Rfc1 G A 5: 65,459,347 (GRCm39) Q190* probably null Het
Rfc1 A G 5: 65,470,304 (GRCm39) S68P probably damaging Het
Rnf145 T C 11: 44,452,317 (GRCm39) V432A probably benign Het
Ror2 A G 13: 53,273,018 (GRCm39) S204P probably damaging Het
Scn1a T C 2: 66,162,631 (GRCm39) E205G probably damaging Het
Slc2a8 A C 2: 32,866,189 (GRCm39) M277R probably damaging Het
Slc4a1 T C 11: 102,245,249 (GRCm39) Y566C probably damaging Het
Slc6a12 A G 6: 121,331,262 (GRCm39) N185S probably benign Het
Srcap GCTCCTCCTCCTCCTCCT GCTCCTCCTCCTCCT 7: 127,157,482 (GRCm39) probably benign Het
Stk33 T A 7: 108,926,823 (GRCm39) T279S possibly damaging Het
Taok3 A G 5: 117,379,015 (GRCm39) probably benign Het
Tlr11 A G 14: 50,599,561 (GRCm39) T516A probably benign Het
Tmem132c T A 5: 127,641,093 (GRCm39) L1088Q possibly damaging Het
Tmem132d T A 5: 127,861,485 (GRCm39) M879L probably benign Het
Tnk2 A G 16: 32,489,687 (GRCm39) E322G probably damaging Het
Ttc28 T C 5: 111,433,302 (GRCm39) V2081A probably benign Het
Ttn C T 2: 76,624,753 (GRCm39) probably null Het
Zswim2 T C 2: 83,745,753 (GRCm39) R562G probably benign Het
Other mutations in Zfp105
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1416:Zfp105 UTSW 9 122,759,742 (GRCm39) missense probably damaging 1.00
R1717:Zfp105 UTSW 9 122,759,696 (GRCm39) missense probably damaging 1.00
R2119:Zfp105 UTSW 9 122,758,743 (GRCm39) nonsense probably null
R4522:Zfp105 UTSW 9 122,759,121 (GRCm39) missense possibly damaging 0.88
R4953:Zfp105 UTSW 9 122,758,880 (GRCm39) missense probably benign 0.10
R5523:Zfp105 UTSW 9 122,755,454 (GRCm39) missense probably benign 0.00
R6943:Zfp105 UTSW 9 122,754,303 (GRCm39) missense probably benign
R7102:Zfp105 UTSW 9 122,758,869 (GRCm39) missense probably damaging 1.00
R7827:Zfp105 UTSW 9 122,759,808 (GRCm39) missense probably damaging 1.00
R8065:Zfp105 UTSW 9 122,754,194 (GRCm39) missense probably benign
R8823:Zfp105 UTSW 9 122,759,568 (GRCm39) missense possibly damaging 0.69
R9037:Zfp105 UTSW 9 122,758,836 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TCAGAGTGCAAATCTTGTTGTG -3'
(R):5'- AAAGCTGCACCACACTTTGC -3'

Sequencing Primer
(F):5'- AAGTGCAAACCTCGTTGTGC -3'
(R):5'- TATGAGCTACAAGTGAAGGCCTTCC -3'
Posted On 2018-08-01