|Institutional Source||Beutler Lab|
|Gene Name||forkhead box S1|
|Synonyms||Fkh3, FREAC10, Fkhl18|
|Essential gene?||Possibly non essential (E-score: 0.340)|
|Stock #||R6720 (G1)|
|Chromosomal Location||152931898-152933208 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 152932720 bp (GRCm38)|
|Amino Acid Change||Serine to Cysteine at position 138 (S138C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000096806 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000099200]|
AA Change: S138C
PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
AA Change: S138C
|Meta Mutation Damage Score||0.0618|
|Coding Region Coverage||
|Validation Efficiency||98% (50/51)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for one reporter allele display enhanced rotarod performance and increased male resistance to diet-induced obesity. Homozygotes for another reporter allele show impaired testicular vasculature, including blood accumulation in fetal testis and marked apoptosis of periendothelial cells. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Foxs1||
(F):5'- GACTTTGCCGAGCACATCTC -3'
(R):5'- GCCATAACCTGTCTCTCAACGAG -3'
(F):5'- GAGCACATCTCTTTGGGTCCAG -3'
(R):5'- TCAAGGTGCCTCGTGATGAC -3'