Incidental Mutation 'R6720:Gm19410'
ID529539
Institutional Source Beutler Lab
Gene Symbol Gm19410
Ensembl Gene ENSMUSG00000109372
Gene Namepredicted gene, 19410
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.158) question?
Stock #R6720 (G1)
Quality Score225.009
Status Validated
Chromosome8
Chromosomal Location35765790-35818047 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 35807576 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Glutamine at position 1517 (R1517Q)
Ref Sequence ENSEMBL: ENSMUSP00000147162 (fasta)
Predicted Effect probably benign
Transcript: ENSMUST00000207505
AA Change: R1517Q

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.6%
Validation Efficiency 98% (50/51)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik G A 4: 137,454,686 E51K possibly damaging Het
Abca1 A C 4: 53,083,733 L700R probably damaging Het
Arpc1a C A 5: 145,101,222 probably null Het
Baz2b G T 2: 59,924,890 P241Q probably damaging Het
Cd6 T A 19: 10,794,609 T414S probably benign Het
Ces2b A T 8: 104,836,869 E409D probably benign Het
Cfap54 A G 10: 92,821,119 Y3024H probably benign Het
Chrm1 A G 19: 8,678,548 T206A probably benign Het
Clptm1l T C 13: 73,618,516 W512R probably damaging Het
Col15a1 T A 4: 47,247,552 probably null Het
Cox15 A G 19: 43,736,789 S392P probably damaging Het
Cr2 T C 1: 195,155,200 M1197V probably damaging Het
Ddx60 A G 8: 62,000,689 K1281E probably benign Het
Dnah11 A G 12: 118,045,646 F2094L probably damaging Het
Ear2 T A 14: 44,102,959 C25S probably damaging Het
Ect2l T C 10: 18,140,264 D802G probably damaging Het
Eftud2 G A 11: 102,838,623 Q84* probably null Het
Eif4g3 T A 4: 138,175,832 probably null Het
Ephb2 T C 4: 136,657,502 D866G probably damaging Het
Fam129b T A 2: 32,905,826 V22D probably damaging Het
Farsb A G 1: 78,472,497 M99T probably damaging Het
Foxs1 T A 2: 152,932,720 S138C probably damaging Het
Frem1 T G 4: 83,013,832 S211R probably damaging Het
Gria2 T C 3: 80,802,304 I27M probably benign Het
H2-Q7 A G 17: 35,442,678 E299G probably benign Het
Hao2 T G 3: 98,877,135 I305L probably benign Het
Hectd4 C T 5: 121,307,381 Q122* probably null Het
Hivep1 T A 13: 42,164,284 C2079S probably damaging Het
Hoxb1 C A 11: 96,366,987 Q248K probably damaging Het
Hspb6 A G 7: 30,554,347 D95G probably benign Het
Ighv5-2 T A 12: 113,578,506 R117S probably damaging Het
Ino80d A C 1: 63,058,610 S708R probably damaging Het
Lman1l A G 9: 57,614,072 probably null Het
Mmp15 A G 8: 95,365,314 N51D probably benign Het
Naip1 T C 13: 100,423,077 M1140V probably benign Het
Olfr1053 A G 2: 86,315,065 S74P probably damaging Het
Olfr1373 A G 11: 52,144,693 V279A probably benign Het
Olfr397 A G 11: 73,965,465 N286D probably damaging Het
Olfr890 T A 9: 38,143,153 M1K probably null Het
Pard3b A T 1: 62,159,470 N239I probably damaging Het
Parvb C T 15: 84,297,979 R237W probably damaging Het
Pcdha9 T C 18: 36,998,069 S64P probably damaging Het
Pdcd1 T C 1: 94,041,389 N68S probably benign Het
Pi4ka G T 16: 17,326,052 probably null Het
Plekha4 A T 7: 45,540,886 D359V possibly damaging Het
Serpinb13 A G 1: 106,994,062 I78V probably benign Het
Slc39a7 T A 17: 34,030,108 T269S probably benign Het
Sltm T G 9: 70,573,710 D281E probably damaging Het
Zfp708 T C 13: 67,071,432 Y76C probably damaging Het
Zfp990 T A 4: 145,536,927 V165D possibly damaging Het
Other mutations in Gm19410
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0046:Gm19410 UTSW 8 35802645 missense probably benign 0.31
R6026:Gm19410 UTSW 8 35812426 missense probably benign 0.03
R6039:Gm19410 UTSW 8 35809364 missense probably benign 0.44
R6039:Gm19410 UTSW 8 35809364 missense probably benign 0.44
R6185:Gm19410 UTSW 8 35807510 missense possibly damaging 0.87
R6239:Gm19410 UTSW 8 35778764 missense probably damaging 0.98
R6303:Gm19410 UTSW 8 35807560 missense possibly damaging 0.96
R6377:Gm19410 UTSW 8 35803582 nonsense probably null
R6545:Gm19410 UTSW 8 35790498 missense possibly damaging 0.93
R6700:Gm19410 UTSW 8 35807510 missense possibly damaging 0.87
R6795:Gm19410 UTSW 8 35795522 missense probably damaging 0.98
R6808:Gm19410 UTSW 8 35772579 missense probably damaging 0.99
R6810:Gm19410 UTSW 8 35772579 missense probably damaging 0.99
R6811:Gm19410 UTSW 8 35772579 missense probably damaging 0.99
R6966:Gm19410 UTSW 8 35817973 missense possibly damaging 0.84
R7264:Gm19410 UTSW 8 35785766 missense probably benign 0.01
R7267:Gm19410 UTSW 8 35814843 missense possibly damaging 0.80
R7355:Gm19410 UTSW 8 35807072 missense probably benign 0.00
R7423:Gm19410 UTSW 8 35804607 missense probably benign 0.28
R7494:Gm19410 UTSW 8 35795530 missense probably damaging 0.99
R7516:Gm19410 UTSW 8 35796279 missense probably benign 0.30
R7517:Gm19410 UTSW 8 35773618 missense possibly damaging 0.45
R7526:Gm19410 UTSW 8 35790612 missense probably damaging 0.98
R7527:Gm19410 UTSW 8 35802232 missense probably damaging 0.99
R7545:Gm19410 UTSW 8 35802625 missense probably damaging 0.99
R7549:Gm19410 UTSW 8 35799346 missense probably benign 0.20
R7564:Gm19410 UTSW 8 35806997 missense probably benign 0.00
R7615:Gm19410 UTSW 8 35796359 missense probably damaging 1.00
R7622:Gm19410 UTSW 8 35810347 missense possibly damaging 0.91
R7655:Gm19410 UTSW 8 35809099 missense probably benign
R7656:Gm19410 UTSW 8 35809099 missense probably benign
R7703:Gm19410 UTSW 8 35799385 missense probably damaging 0.98
R7750:Gm19410 UTSW 8 35807498 missense possibly damaging 0.68
R7760:Gm19410 UTSW 8 35802337 missense probably damaging 0.99
R7837:Gm19410 UTSW 8 35808980 missense possibly damaging 0.91
R7920:Gm19410 UTSW 8 35808980 missense possibly damaging 0.91
Z1176:Gm19410 UTSW 8 35792611 missense possibly damaging 0.79
Z1177:Gm19410 UTSW 8 35808965 missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- GGCACCATCTACAGCAATTAAG -3'
(R):5'- TTCAAGGGAAAGAGCCTCCAC -3'

Sequencing Primer
(F):5'- ATGTTAAGCATGCATGAGGCTC -3'
(R):5'- TGGAGACATCTACACTCAGTCAG -3'
Posted On2018-08-01