Incidental Mutation 'IGL01141:Gm4758'
ID52970
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4758
Ensembl Gene ENSMUSG00000079595
Gene Namepredicted gene 4758
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL01141
Quality Score
Status
Chromosome16
Chromosomal Location36308045-36312653 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 36308064 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 7 (E7G)
Ref Sequence ENSEMBL: ENSMUSP00000110501 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114851]
Predicted Effect probably benign
Transcript: ENSMUST00000114851
AA Change: E7G

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000110501
Gene: ENSMUSG00000079595
AA Change: E7G

DomainStartEndE-ValueType
CY 1 96 1.9e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157239
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232642
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,937,730 D1447E probably damaging Het
Atp2a3 T C 11: 72,982,665 I788T probably damaging Het
Axin1 G A 17: 26,190,041 E672K probably damaging Het
Ccno A G 13: 112,989,027 D175G probably damaging Het
Cep83 C A 10: 94,788,757 T632K probably benign Het
Ckmt1 A T 2: 121,362,993 I345F probably benign Het
Cntnap1 G A 11: 101,178,807 probably benign Het
Edem2 A G 2: 155,709,028 Y340H probably benign Het
Erich3 A G 3: 154,714,016 K249R probably benign Het
Fndc9 T C 11: 46,237,699 I15T probably benign Het
Grip2 G T 6: 91,782,897 Q300K probably benign Het
Herc2 T C 7: 56,212,841 V4050A possibly damaging Het
Jup A T 11: 100,386,249 D44E probably benign Het
Lingo3 G T 10: 80,835,313 P261Q probably damaging Het
Lrrfip2 C T 9: 111,219,715 R311W probably damaging Het
Mansc1 C A 6: 134,621,785 L56F probably benign Het
Map1b A G 13: 99,434,761 I484T probably damaging Het
Mpeg1 T A 19: 12,462,785 F536I probably damaging Het
Mrgprb1 T G 7: 48,448,027 T46P probably benign Het
Mug1 A G 6: 121,870,499 N612S probably benign Het
Olfr477 T C 7: 107,990,551 F62S probably damaging Het
Olfr805 T A 10: 129,722,945 I200L probably benign Het
Pax8 A G 2: 24,441,150 S178P probably damaging Het
Peak1 A G 9: 56,258,527 F706L probably benign Het
Prkdc A G 16: 15,726,704 T1853A probably damaging Het
Reln A C 5: 21,969,033 F2024C probably damaging Het
Reln G T 5: 21,919,069 P2813Q probably damaging Het
Riox1 A G 12: 83,951,794 Q368R probably damaging Het
Rspry1 T C 8: 94,649,855 V335A probably benign Het
Scn3a T C 2: 65,495,113 N1020S possibly damaging Het
Scyl2 A G 10: 89,640,635 V876A probably benign Het
Sdhaf3 T A 6: 6,956,141 F39I probably damaging Het
Sfxn4 T C 19: 60,851,014 E202G possibly damaging Het
Slc1a4 A T 11: 20,308,644 probably benign Het
Sln A G 9: 53,853,500 I10V probably benign Het
Ssh2 A G 11: 77,449,726 E568G probably damaging Het
Supt7l G A 5: 31,518,435 P270S probably benign Het
Tanc2 A G 11: 105,886,474 probably benign Het
Tatdn1 A T 15: 58,909,567 probably benign Het
Tfip11 C T 5: 112,329,503 P117L possibly damaging Het
Vpreb1 T C 16: 16,869,087 M9V probably benign Het
Other mutations in Gm4758
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01787:Gm4758 APN 16 36311229 missense probably damaging 1.00
IGL02114:Gm4758 APN 16 36311255 nonsense probably null
IGL02547:Gm4758 APN 16 36312526 critical splice acceptor site probably benign
R1800:Gm4758 UTSW 16 36312533 missense probably damaging 0.98
R1858:Gm4758 UTSW 16 36308087 missense probably damaging 1.00
R1958:Gm4758 UTSW 16 36312565 missense possibly damaging 0.78
R4424:Gm4758 UTSW 16 36312589 unclassified probably null 0.52
R4618:Gm4758 UTSW 16 36312590 missense possibly damaging 0.69
R5162:Gm4758 UTSW 16 36312556 missense probably damaging 1.00
R6437:Gm4758 UTSW 16 36312637 missense probably damaging 1.00
Posted On2013-06-21