Incidental Mutation 'R6724:Kifc1'
ID 529790
Institutional Source Beutler Lab
Gene Symbol Kifc1
Ensembl Gene ENSMUSG00000079553
Gene Name kinesin family member C1
Synonyms Tctex7a, Tctex7, HSET, kinesin family c-terminal 5A, Tctex-7, KNSL2, Knsl2a, Tctex-7A, Gm4137, Kifc5a
MMRRC Submission 044842-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6724 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 34094640-34109607 bp(-) (GRCm39)
Type of Mutation splice site (31 bp from exon)
DNA Base Change (assembly) T to A at 34105707 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134572 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114361] [ENSMUST00000173386] [ENSMUST00000173492]
AlphaFold Q9QWT9
Predicted Effect probably null
Transcript: ENSMUST00000114361
SMART Domains Protein: ENSMUSP00000110001
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
low complexity region 65 76 N/A INTRINSIC
Blast:KISc 82 155 2e-12 BLAST
low complexity region 156 179 N/A INTRINSIC
KISc 246 609 1.77e-143 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172608
Predicted Effect probably null
Transcript: ENSMUST00000173386
SMART Domains Protein: ENSMUSP00000133758
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
Blast:KISc 67 204 4e-31 BLAST
low complexity region 206 218 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000173492
SMART Domains Protein: ENSMUSP00000134572
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
low complexity region 108 119 N/A INTRINSIC
low complexity region 224 242 N/A INTRINSIC
KISc 309 672 1.77e-143 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173885
Predicted Effect probably benign
Transcript: ENSMUST00000173982
SMART Domains Protein: ENSMUSP00000133520
Gene: ENSMUSG00000079553

DomainStartEndE-ValueType
Blast:KISc 2 44 8e-22 BLAST
PDB:2REP|A 2 51 6e-20 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174507
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185129
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts5 T A 16: 85,665,445 (GRCm39) T619S probably benign Het
Adgra2 G A 8: 27,604,210 (GRCm39) A467T possibly damaging Het
Alox5 A T 6: 116,391,509 (GRCm39) I416N probably damaging Het
Blmh A G 11: 76,862,733 (GRCm39) probably null Het
Cftr T A 6: 18,255,973 (GRCm39) Y567* probably null Het
Cnr1 T A 4: 33,944,728 (GRCm39) M372K possibly damaging Het
Col6a3 T C 1: 90,706,874 (GRCm39) T2080A unknown Het
Crybg3 A T 16: 59,364,501 (GRCm39) C2374S probably benign Het
Csmd2 A G 4: 128,457,164 (GRCm39) I3544V probably damaging Het
Dnah12 A T 14: 26,518,180 (GRCm39) D1809V probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dnajb12 A G 10: 59,728,602 (GRCm39) D190G possibly damaging Het
Dtnb T A 12: 3,736,817 (GRCm39) V319D probably damaging Het
Eif1ad6 A T 12: 87,668,754 (GRCm39) I129F unknown Het
Ercc6 A T 14: 32,288,288 (GRCm39) E820V probably benign Het
Fip1l1 T G 5: 74,752,435 (GRCm39) V378G probably damaging Het
Gabrg1 T A 5: 70,911,552 (GRCm39) Y358F possibly damaging Het
Gcn1 T G 5: 115,747,217 (GRCm39) probably null Het
Gm11011 T A 2: 169,429,402 (GRCm39) T28S unknown Het
Guf1 C A 5: 69,723,736 (GRCm39) N438K probably damaging Het
Hoxa7 T C 6: 52,192,719 (GRCm39) E223G probably benign Het
Hspg2 G A 4: 137,242,618 (GRCm39) G611E probably damaging Het
Ipo8 A T 6: 148,711,473 (GRCm39) probably null Het
Isl2 A G 9: 55,448,572 (GRCm39) D3G possibly damaging Het
Kcnb2 A G 1: 15,780,664 (GRCm39) Y512C probably damaging Het
Klhdc10 A G 6: 30,446,640 (GRCm39) D183G probably damaging Het
Klra5 T A 6: 129,883,643 (GRCm39) K71N probably benign Het
Lrp6 T C 6: 134,463,504 (GRCm39) H559R possibly damaging Het
Maml3 T C 3: 51,763,296 (GRCm39) N556S probably damaging Het
Man2a1 A G 17: 65,038,264 (GRCm39) I83V possibly damaging Het
Mrgpra9 A G 7: 46,884,786 (GRCm39) S293P probably damaging Het
Nalcn A G 14: 123,535,479 (GRCm39) S1282P probably damaging Het
Npepps A T 11: 97,096,828 (GRCm39) probably benign Het
Or4a72 A T 2: 89,405,309 (GRCm39) F254I probably benign Het
Or4c108 T G 2: 88,803,612 (GRCm39) I208L probably benign Het
Or8u10 A T 2: 85,915,701 (GRCm39) V140E possibly damaging Het
Or9m1 T G 2: 87,733,946 (GRCm39) S25R probably benign Het
Pkn3 C A 2: 29,980,562 (GRCm39) R818S possibly damaging Het
Plekha3 T A 2: 76,517,745 (GRCm39) H190Q probably damaging Het
Ppp2r3c A T 12: 55,335,281 (GRCm39) S261T probably benign Het
Ptprj T C 2: 90,281,195 (GRCm39) D1015G probably benign Het
Pus10 T C 11: 23,679,037 (GRCm39) M503T possibly damaging Het
Pvr T C 7: 19,652,604 (GRCm39) R104G possibly damaging Het
Rubcnl A G 14: 75,289,450 (GRCm39) R653G probably benign Het
Semp2l2a A T 8: 13,887,083 (GRCm39) L336Q probably damaging Het
Serpina1a G T 12: 103,826,679 (GRCm39) probably benign Het
Shank3 G A 15: 89,416,656 (GRCm39) R265Q probably damaging Het
Slc22a22 C T 15: 57,110,928 (GRCm39) R433H probably damaging Het
Slc22a26 A G 19: 7,779,726 (GRCm39) I30T probably benign Het
Spz1 A T 13: 92,711,992 (GRCm39) N161K possibly damaging Het
Tacc2 A G 7: 130,330,492 (GRCm39) R259G probably damaging Het
Top1 G A 2: 160,554,616 (GRCm39) V456M probably damaging Het
Tpcn2 G A 7: 144,810,257 (GRCm39) A649V probably benign Het
Trank1 C G 9: 111,194,984 (GRCm39) R1003G probably damaging Het
Tril T A 6: 53,796,559 (GRCm39) H221L possibly damaging Het
Unc79 C T 12: 103,071,120 (GRCm39) T1305I probably damaging Het
Unc80 C T 1: 66,722,350 (GRCm39) A2988V possibly damaging Het
Vinac1 A C 2: 128,879,976 (GRCm39) V650G probably benign Het
Vmn1r81 A T 7: 11,994,599 (GRCm39) M3K probably damaging Het
Vmn2r78 A T 7: 86,603,466 (GRCm39) D548V probably damaging Het
Vwa3b G A 1: 37,084,112 (GRCm39) R95Q probably damaging Het
Wdr6 G A 9: 108,452,093 (GRCm39) H597Y probably benign Het
Yme1l1 C T 2: 23,084,774 (GRCm39) T624I probably damaging Het
Other mutations in Kifc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02707:Kifc1 APN 17 34,100,467 (GRCm39) nonsense probably null
R0540:Kifc1 UTSW 17 34,105,621 (GRCm39) missense probably damaging 0.98
R0607:Kifc1 UTSW 17 34,105,621 (GRCm39) missense probably damaging 0.98
R1019:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1218:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1219:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1222:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1374:Kifc1 UTSW 17 34,102,849 (GRCm39) missense probably benign 0.12
R1523:Kifc1 UTSW 17 34,102,636 (GRCm39) missense probably benign 0.23
R1818:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1958:Kifc1 UTSW 17 34,103,685 (GRCm39) missense probably benign 0.02
R1960:Kifc1 UTSW 17 34,103,561 (GRCm39) critical splice donor site probably null
R5439:Kifc1 UTSW 17 34,105,639 (GRCm39) missense probably damaging 1.00
R5941:Kifc1 UTSW 17 34,102,059 (GRCm39) splice site probably benign
R6643:Kifc1 UTSW 17 34,104,829 (GRCm39) missense probably benign 0.23
R6663:Kifc1 UTSW 17 34,100,430 (GRCm39) unclassified probably benign
R7033:Kifc1 UTSW 17 34,102,671 (GRCm39) missense probably damaging 1.00
R7498:Kifc1 UTSW 17 34,102,846 (GRCm39) missense probably benign
R7515:Kifc1 UTSW 17 34,103,777 (GRCm39) missense probably damaging 1.00
R7733:Kifc1 UTSW 17 34,102,543 (GRCm39) missense probably damaging 1.00
R7803:Kifc1 UTSW 17 34,103,714 (GRCm39) missense probably benign
R7947:Kifc1 UTSW 17 34,102,849 (GRCm39) missense probably benign 0.12
R8024:Kifc1 UTSW 17 34,102,177 (GRCm39) missense probably damaging 1.00
R8979:Kifc1 UTSW 17 34,102,228 (GRCm39) missense possibly damaging 0.56
R9259:Kifc1 UTSW 17 34,101,165 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GGGGATTATCCACTCAGAGACAG -3'
(R):5'- ACAGAGGCCACCTTTGTTGG -3'

Sequencing Primer
(F):5'- GGAGAGAGCAGTACACTTCCAC -3'
(R):5'- CCACCTTTGTTGGAAGTGAAGAG -3'
Posted On 2018-08-01