Incidental Mutation 'IGL01155:Mzt2'
ID 52986
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mzt2
Ensembl Gene ENSMUSG00000022671
Gene Name mitotic spindle organizing protein 2
Synonyms 2610001E06Rik, 2410018G20Rik, Fam128b
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # IGL01155
Quality Score
Chromosome 16
Chromosomal Location 15666305-15681233 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 15680274 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 104 (S104A)
Ref Sequence ENSEMBL: ENSMUSP00000155739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023351] [ENSMUST00000117136] [ENSMUST00000229680]
AlphaFold Q9CQ25
Predicted Effect probably benign
Transcript: ENSMUST00000023351
AA Change: S104A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000023351
Gene: ENSMUSG00000022671
AA Change: S104A

Pfam:MOZART2 1 99 1.4e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117136
AA Change: S104A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000113832
Gene: ENSMUSG00000022671
AA Change: S104A

Pfam:MOZART2 11 98 4.5e-44 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137864
Predicted Effect possibly damaging
Transcript: ENSMUST00000229680
AA Change: S104A

PolyPhen 2 Score 0.572 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
Adgrl3 T A 5: 81,708,740 (GRCm39) I409N probably benign Het
Akap13 A G 7: 75,219,684 (GRCm39) D29G probably damaging Het
Ap4e1 C A 2: 126,885,365 (GRCm39) T322K probably damaging Het
Arfgef1 G A 1: 10,269,207 (GRCm39) probably benign Het
Asic5 A G 3: 81,915,895 (GRCm39) T282A probably benign Het
Bptf T C 11: 106,971,553 (GRCm39) T985A probably damaging Het
Btnl9 A G 11: 49,066,518 (GRCm39) F349L probably damaging Het
Bves T A 10: 45,229,955 (GRCm39) I253K probably damaging Het
Cars1 T A 7: 143,123,586 (GRCm39) Y455F probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cuedc2 C A 19: 46,321,088 (GRCm39) V15F probably damaging Het
Defa22 T A 8: 21,653,053 (GRCm39) probably null Het
Fat1 G A 8: 45,476,986 (GRCm39) A2011T probably damaging Het
Fyb2 C T 4: 104,856,583 (GRCm39) T533I probably benign Het
Gm1043 T C 5: 37,344,433 (GRCm39) L182P probably damaging Het
Ice1 A T 13: 70,752,201 (GRCm39) V1295E possibly damaging Het
Il12b T A 11: 44,294,915 (GRCm39) S18T probably benign Het
Iqcg A G 16: 32,861,245 (GRCm39) V157A probably damaging Het
Itgax T A 7: 127,744,207 (GRCm39) M937K probably benign Het
Large1 T C 8: 73,858,617 (GRCm39) S84G probably benign Het
Lrp1b T C 2: 41,660,947 (GRCm39) T54A probably benign Het
Mfn1 A G 3: 32,596,985 (GRCm39) M148V probably damaging Het
Mobp C A 9: 119,997,300 (GRCm39) T73K probably benign Het
Ms4a3 T C 19: 11,607,019 (GRCm39) probably benign Het
Muc5ac C T 7: 141,360,680 (GRCm39) probably benign Het
Naa16 T A 14: 79,622,155 (GRCm39) K27N probably damaging Het
Nos1 T A 5: 118,083,991 (GRCm39) I1267N probably damaging Het
Or10j5 T A 1: 172,784,491 (GRCm39) I43N probably benign Het
Rara A G 11: 98,859,010 (GRCm39) E153G possibly damaging Het
Scn2a T G 2: 65,548,092 (GRCm39) S66A probably damaging Het
Slc6a1 A T 6: 114,291,426 (GRCm39) probably null Het
Sorbs3 A G 14: 70,436,790 (GRCm39) V136A probably damaging Het
Spink5 T A 18: 44,114,214 (GRCm39) H143Q probably benign Het
Susd2 G A 10: 75,476,726 (GRCm39) T99I possibly damaging Het
T C T 17: 8,660,577 (GRCm39) probably null Het
Tac2 G A 10: 127,562,003 (GRCm39) probably null Het
Tfap4 G T 16: 4,365,223 (GRCm39) P180T probably damaging Het
Trap1 G A 16: 3,861,842 (GRCm39) Q641* probably null Het
Unc119 A G 11: 78,239,435 (GRCm39) N252S probably damaging Het
Other mutations in Mzt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01688:Mzt2 APN 16 15,680,793 (GRCm39) start gained probably benign
R1962:Mzt2 UTSW 16 15,666,543 (GRCm39) missense probably damaging 0.99
R2885:Mzt2 UTSW 16 15,680,780 (GRCm39) missense unknown
R6192:Mzt2 UTSW 16 15,666,551 (GRCm39) missense probably benign 0.12
R7560:Mzt2 UTSW 16 15,680,669 (GRCm39) missense possibly damaging 0.86
R9106:Mzt2 UTSW 16 15,666,568 (GRCm39) missense probably benign 0.00
Posted On 2013-06-21