Mutagenetix > Incidental Mutation

Incidental Mutation 'R6726:Vmn2r107'

529884

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R6726 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 20375375 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 730 (G730D)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: G730D

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: G730D

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.3%

Validation Efficiency

100% (41/41)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930017K11Rik	G	C	17: 25,947,715	P283A	probably benign	Het
Acot11	C	T	4: 106,760,130	G240R	probably damaging	Het
Arfgef2	T	A	2: 166,893,620		probably null	Het
Arsk	T	C	13: 76,074,788	Y230C	probably damaging	Het
Atf7ip	G	A	6: 136,582,391	V737M	probably damaging	Het
Atp6v1e1	A	T	6: 120,804,050		probably null	Het
Bbs9	T	C	9: 22,645,964	V3A	probably benign	Het
Brap	T	C	5: 121,675,302	S243P	probably damaging	Het
Camkmt	T	A	17: 85,394,609	I167N	probably damaging	Het
Ckap2l	C	A	2: 129,269,194	E694D	probably damaging	Het
Crmp1	G	A	5: 37,284,064	V497I	probably benign	Het
Dbx2	A	G	15: 95,624,860	V322A	possibly damaging	Het
Dll1	C	A	17: 15,370,251	C401F	probably damaging	Het
Dock10	T	C	1: 80,512,430	T1991A	probably damaging	Het
Dock3	C	T	9: 107,159,452	W42*	probably null	Het
Epha6	C	A	16: 60,424,835	A334S	possibly damaging	Het
Gm10093	A	G	17: 78,492,858	E426G	probably damaging	Het
Gm5737	T	C	7: 120,826,109	S308P	probably damaging	Het
Insrr	C	T	3: 87,813,566	R1044C	probably damaging	Het
Irs2	T	C	8: 11,004,961	N1157S	possibly damaging	Het
Kndc1	T	C	7: 139,922,751		probably null	Het
Map3k19	T	C	1: 127,820,448	N1241S	probably benign	Het
Olfr1015	T	C	2: 85,785,562	F17S	possibly damaging	Het
Paqr5	C	T	9: 61,963,783	R171Q	probably damaging	Het
Pcdh17	T	A	14: 84,446,217	D41E	probably damaging	Het
Plg	T	G	17: 12,378,708	L14R	probably damaging	Het
Prkab1	A	G	5: 116,020,033	V168A	probably benign	Het
Ptdss1	C	T	13: 66,953,531	R95*	probably null	Het
Rab3gap2	T	G	1: 185,247,865	S327A	probably damaging	Het
Rnd2	C	T	11: 101,468,999	L57F	probably damaging	Het
Rsf1	G	A	7: 97,579,910		probably benign	Homo
Senp8	C	A	9: 59,737,190	V228L	probably benign	Het
Serpina10	A	T	12: 103,628,369	I197K	probably benign	Het
Serpinb6d	A	G	13: 33,670,735	N231S	probably benign	Het
Sez6l2	T	C	7: 126,968,005	V869A	probably damaging	Het
Sgo2b	T	A	8: 63,927,735	K688*	probably null	Het
Sh3kbp1	A	T	X: 159,841,180	E39D	probably benign	Homo
Ufsp2	T	C	8: 45,985,467	M194T	probably benign	Het
Ush2a	T	C	1: 188,753,684	I2997T	possibly damaging	Het
Wdr72	T	C	9: 74,152,540	Y411H	possibly damaging	Het
Xirp2	T	C	2: 67,512,868	S1818P	possibly damaging	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AAAGCTATCACTGTGGTTCTTGC -3'
(R):5'- TCCCTTTAGTGCTGTGGTAGAC -3'

Sequencing Primer
(F):5'- GCCTTTAAGGTCAGTTTTCCAG -3'
(R):5'- GGTGATCCAGACACAGAAGAATACC -3'

Posted On

2018-08-01