Incidental Mutation 'R6729:Olfr920'
ID 529976
Institutional Source Beutler Lab
Gene Symbol Olfr920
Ensembl Gene ENSMUSG00000061039
Gene Name olfactory receptor 920
Synonyms MOR165-6, GA_x6K02T2PVTD-32458442-32459374
MMRRC Submission 044847-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R6729 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 38752299-38760117 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38755828 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 47 (I47V)
Ref Sequence ENSEMBL: ENSMUSP00000074300 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074740]
AlphaFold E9Q413
Predicted Effect probably benign
Transcript: ENSMUST00000074740
AA Change: I47V

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000074300
Gene: ENSMUSG00000061039
AA Change: I47V

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.2e-47 PFAM
Pfam:7tm_1 41 290 3.6e-22 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.4%
  • 20x: 95.5%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik T C 15: 8,188,601 probably null Het
Acad12 A T 5: 121,607,935 H230Q probably damaging Het
AI182371 G T 2: 35,084,705 probably benign Het
Ank3 T C 10: 69,808,925 V73A probably damaging Het
Apbb1 A T 7: 105,565,381 M28K probably damaging Het
Atp6v1f A G 6: 29,467,965 D50G probably benign Het
Cdkal1 G A 13: 29,474,695 T356M probably damaging Het
Clca1 A G 3: 145,005,966 I756T probably damaging Het
Cyp17a1 A G 19: 46,670,581 V207A probably benign Het
Dnah7c A G 1: 46,672,521 E2636G possibly damaging Het
Gm13090 A T 4: 151,089,628 probably benign Het
Nceh1 T A 3: 27,241,271 L227* probably null Het
Nedd9 A G 13: 41,315,802 M625T probably damaging Het
Olfr1426 T A 19: 12,088,496 M99L probably benign Het
Olfr148 A T 9: 39,613,773 M69L probably benign Het
Olfr464 G A 11: 87,914,850 Q19* probably null Het
Pcsk4 T C 10: 80,325,101 N297S probably damaging Het
Psg21 T A 7: 18,652,591 I157F probably damaging Het
Rabep2 T C 7: 126,440,197 V294A probably benign Het
Rsph1 A G 17: 31,277,252 S2P unknown Het
Sacs A G 14: 61,210,518 K3338E probably damaging Het
Slc35f4 T G 14: 49,318,960 N112T probably benign Het
Slc43a3 T C 2: 84,938,285 F83L probably damaging Het
Slc6a15 T C 10: 103,393,914 V154A probably damaging Het
Synj2 T A 17: 5,986,014 M1K probably null Het
Tcp1 G A 17: 12,923,253 R378Q probably damaging Het
Tead2 A G 7: 45,217,234 T6A probably benign Het
Tpte G T 8: 22,355,475 V514L probably damaging Het
Trpm6 A G 19: 18,830,297 N1069D probably damaging Het
Uhrf1bp1l T A 10: 89,805,684 S906T probably benign Het
Vmn2r105 C A 17: 20,208,343 G824C probably damaging Het
Yod1 G A 1: 130,717,538 G19S probably damaging Het
Zfp934 A T 13: 62,492,932 N2K probably damaging Het
Other mutations in Olfr920
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01686:Olfr920 APN 9 38756254 missense probably damaging 1.00
IGL01728:Olfr920 APN 9 38756095 missense possibly damaging 0.63
IGL01867:Olfr920 APN 9 38755898 missense probably damaging 1.00
IGL02271:Olfr920 APN 9 38756488 missense probably benign
IGL03078:Olfr920 APN 9 38756245 nonsense probably null
R0166:Olfr920 UTSW 9 38756188 missense probably benign
R0446:Olfr920 UTSW 9 38755818 missense probably damaging 1.00
R0453:Olfr920 UTSW 9 38756129 missense probably damaging 0.99
R0556:Olfr920 UTSW 9 38755745 missense possibly damaging 0.88
R1585:Olfr920 UTSW 9 38756420 missense probably damaging 1.00
R2847:Olfr920 UTSW 9 38756036 missense possibly damaging 0.89
R4676:Olfr920 UTSW 9 38755659 start gained probably benign
R4825:Olfr920 UTSW 9 38756407 missense probably damaging 1.00
R5026:Olfr920 UTSW 9 38755745 missense probably benign 0.01
R5144:Olfr920 UTSW 9 38756393 missense possibly damaging 0.90
R5573:Olfr920 UTSW 9 38755704 missense probably damaging 1.00
R5872:Olfr920 UTSW 9 38756116 missense probably benign 0.06
R6131:Olfr920 UTSW 9 38756066 missense probably damaging 1.00
R7731:Olfr920 UTSW 9 38756246 missense possibly damaging 0.90
R7800:Olfr920 UTSW 9 38756618 missense probably damaging 0.97
R8960:Olfr920 UTSW 9 38756089 missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- AGCCCCACTCTCAGGATTAGAG -3'
(R):5'- CGATCATAGGCCATTGATGTGAG -3'

Sequencing Primer
(F):5'- CACTCTCAGGATTAGAGATCTTCATG -3'
(R):5'- GGCCATTGATGTGAGAATATAACAC -3'
Posted On 2018-08-01