Incidental Mutation 'R6729:Zfp934'
| ID |
529985 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp934
|
| Ensembl Gene |
ENSMUSG00000074865 |
| Gene Name |
zinc finger protein 934 |
| Synonyms |
6720457D02Rik |
| MMRRC Submission |
044847-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.125)
|
| Stock # |
R6729 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
62664609-62727170 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 62640746 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 2
(N2K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152461
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076195]
[ENSMUST00000221250]
[ENSMUST00000222429]
|
| AlphaFold |
K7N6H3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000076195
|
| SMART Domains |
Protein: ENSMUSP00000075552
Gene: ENSMUSG00000055228
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
8.26e-16 |
SMART |
|
ZnF_C2H2
|
133 |
155 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
161 |
183 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
189 |
211 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
217 |
239 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
245 |
267 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
273 |
295 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
8.6e-5 |
SMART |
|
ZnF_C2H2
|
329 |
351 |
1.2e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000221250
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000221494
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222429
AA Change: N2K
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.4%
- 20x: 95.5%
|
| Validation Efficiency |
100% (34/34) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad12 |
A |
T |
5: 121,745,998 (GRCm39) |
H230Q |
probably damaging |
Het |
| AI182371 |
G |
T |
2: 34,974,717 (GRCm39) |
|
probably benign |
Het |
| Ank3 |
T |
C |
10: 69,644,755 (GRCm39) |
V73A |
probably damaging |
Het |
| Apbb1 |
A |
T |
7: 105,214,588 (GRCm39) |
M28K |
probably damaging |
Het |
| Atp6v1f |
A |
G |
6: 29,467,964 (GRCm39) |
D50G |
probably benign |
Het |
| Bltp3b |
T |
A |
10: 89,641,546 (GRCm39) |
S906T |
probably benign |
Het |
| Cdkal1 |
G |
A |
13: 29,658,678 (GRCm39) |
T356M |
probably damaging |
Het |
| Clca3a1 |
A |
G |
3: 144,711,727 (GRCm39) |
I756T |
probably damaging |
Het |
| Cplane1 |
T |
C |
15: 8,218,085 (GRCm39) |
|
probably null |
Het |
| Cyp17a1 |
A |
G |
19: 46,659,020 (GRCm39) |
V207A |
probably benign |
Het |
| Dnah7c |
A |
G |
1: 46,711,681 (GRCm39) |
E2636G |
possibly damaging |
Het |
| Gm13090 |
A |
T |
4: 151,174,085 (GRCm39) |
|
probably benign |
Het |
| Nceh1 |
T |
A |
3: 27,295,420 (GRCm39) |
L227* |
probably null |
Het |
| Nedd9 |
A |
G |
13: 41,469,278 (GRCm39) |
M625T |
probably damaging |
Het |
| Or10n1 |
A |
T |
9: 39,525,069 (GRCm39) |
M69L |
probably benign |
Het |
| Or4d1 |
G |
A |
11: 87,805,676 (GRCm39) |
Q19* |
probably null |
Het |
| Or4d10c |
T |
A |
19: 12,065,860 (GRCm39) |
M99L |
probably benign |
Het |
| Or8b53 |
A |
G |
9: 38,667,124 (GRCm39) |
I47V |
probably benign |
Het |
| Pcsk4 |
T |
C |
10: 80,160,935 (GRCm39) |
N297S |
probably damaging |
Het |
| Psg21 |
T |
A |
7: 18,386,516 (GRCm39) |
I157F |
probably damaging |
Het |
| Rabep2 |
T |
C |
7: 126,039,369 (GRCm39) |
V294A |
probably benign |
Het |
| Rsph1 |
A |
G |
17: 31,496,226 (GRCm39) |
S2P |
unknown |
Het |
| Sacs |
A |
G |
14: 61,447,967 (GRCm39) |
K3338E |
probably damaging |
Het |
| Slc35f4 |
T |
G |
14: 49,556,417 (GRCm39) |
N112T |
probably benign |
Het |
| Slc43a3 |
T |
C |
2: 84,768,629 (GRCm39) |
F83L |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,229,775 (GRCm39) |
V154A |
probably damaging |
Het |
| Synj2 |
T |
A |
17: 6,036,289 (GRCm39) |
M1K |
probably null |
Het |
| Tcp1 |
G |
A |
17: 13,142,140 (GRCm39) |
R378Q |
probably damaging |
Het |
| Tead2 |
A |
G |
7: 44,866,658 (GRCm39) |
T6A |
probably benign |
Het |
| Tpte |
G |
T |
8: 22,845,491 (GRCm39) |
V514L |
probably damaging |
Het |
| Trpm6 |
A |
G |
19: 18,807,661 (GRCm39) |
N1069D |
probably damaging |
Het |
| Vmn2r105 |
C |
A |
17: 20,428,605 (GRCm39) |
G824C |
probably damaging |
Het |
| Yod1 |
G |
A |
1: 130,645,275 (GRCm39) |
G19S |
probably damaging |
Het |
|
| Other mutations in Zfp934 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R1915:Zfp934
|
UTSW |
13 |
62,665,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Zfp934
|
UTSW |
13 |
62,666,108 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2113:Zfp934
|
UTSW |
13 |
62,666,507 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2145:Zfp934
|
UTSW |
13 |
62,665,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3732:Zfp934
|
UTSW |
13 |
62,665,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3797:Zfp934
|
UTSW |
13 |
62,665,702 (GRCm39) |
missense |
probably benign |
|
|
R4326:Zfp934
|
UTSW |
13 |
62,665,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4327:Zfp934
|
UTSW |
13 |
62,665,373 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4909:Zfp934
|
UTSW |
13 |
62,665,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5236:Zfp934
|
UTSW |
13 |
62,665,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5237:Zfp934
|
UTSW |
13 |
62,665,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6305:Zfp934
|
UTSW |
13 |
62,666,370 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7072:Zfp934
|
UTSW |
13 |
62,668,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7186:Zfp934
|
UTSW |
13 |
62,640,204 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7235:Zfp934
|
UTSW |
13 |
62,665,964 (GRCm39) |
missense |
|
|
|
R7453:Zfp934
|
UTSW |
13 |
62,666,517 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7552:Zfp934
|
UTSW |
13 |
62,640,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7589:Zfp934
|
UTSW |
13 |
62,666,130 (GRCm39) |
missense |
|
|
|
R7624:Zfp934
|
UTSW |
13 |
62,666,338 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7651:Zfp934
|
UTSW |
13 |
62,666,327 (GRCm39) |
missense |
probably benign |
|
|
R7780:Zfp934
|
UTSW |
13 |
62,666,358 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7857:Zfp934
|
UTSW |
13 |
62,665,361 (GRCm39) |
missense |
|
|
|
R7891:Zfp934
|
UTSW |
13 |
62,668,003 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8130:Zfp934
|
UTSW |
13 |
62,667,985 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8298:Zfp934
|
UTSW |
13 |
62,666,295 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTATACAGAGAAACCCTGTC -3'
(R):5'- CCCCTGACTGCAGTTATAACT -3'
Sequencing Primer
(F):5'- GAGAAACCCTGTCTCGAAAAAC -3'
(R):5'- GGCTACATCCTATTCAAAGGGCTG -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation