Mutagenetix > Incidental Mutation

Incidental Mutation 'R6730:Vmn2r106'

530036

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

MMRRC Submission

044848-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R6730 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20499096 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 272 (I272L)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167464
AA Change: I272L

PolyPhen 2 Score 0.643 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: I272L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930455H04Rik	T	A	3: 116,777,124 (GRCm39)	*59R	probably null	Het
Adam10	G	T	9: 70,647,458 (GRCm39)		probably null	Het
Adam2	A	T	14: 66,275,025 (GRCm39)	N569K	possibly damaging	Het
Adam20	T	C	8: 41,249,696 (GRCm39)	V602A	probably benign	Het
Adgrb3	T	C	1: 25,133,375 (GRCm39)	Y1237C	probably damaging	Het
Ago3	T	C	4: 126,265,338 (GRCm39)	T318A	probably null	Het
Aknad1	G	A	3: 108,659,655 (GRCm39)	G223D	possibly damaging	Het
Camkv	T	C	9: 107,825,516 (GRCm39)	S478P	possibly damaging	Het
Ccl27a	T	A	4: 41,773,342 (GRCm39)	H39L	probably damaging	Het
Ccser2	C	A	14: 36,601,043 (GRCm39)	S447I	probably damaging	Het
Clvs2	A	G	10: 33,404,517 (GRCm39)	L233P	probably damaging	Het
Csn1s2b	T	A	5: 87,970,127 (GRCm39)	H124Q	probably benign	Het
Dnhd1	T	C	7: 105,353,082 (GRCm39)	L2745P	probably benign	Het
Dync1i2	T	A	2: 71,077,484 (GRCm39)	F219L	probably benign	Het
Eml2	G	A	7: 18,935,088 (GRCm39)	V432I	probably damaging	Het
Ephb6	C	T	6: 41,594,308 (GRCm39)	Q613*	probably null	Het
Erc2	A	C	14: 27,620,524 (GRCm39)	D50A	possibly damaging	Het
Fam149a	T	A	8: 45,834,211 (GRCm39)	D196V	probably damaging	Het
Ficd	T	C	5: 113,876,773 (GRCm39)	V316A	probably damaging	Het
Gstm6	T	A	3: 107,850,041 (GRCm39)	K18*	probably null	Het
Ighv1-62-1	A	T	12: 115,350,512 (GRCm39)	W52R	probably benign	Het
Klhl18	C	T	9: 110,257,979 (GRCm39)	C417Y	probably damaging	Het
Ly9	T	A	1: 171,432,737 (GRCm39)	Y92F	probably benign	Het
Mettl18	C	T	1: 163,824,750 (GRCm39)	T357I	probably damaging	Het
Myoz2	C	A	3: 122,810,276 (GRCm39)	G100C	probably damaging	Het
Or10a49	A	T	7: 108,467,780 (GRCm39)	F194I	probably benign	Het
Or4k47	A	G	2: 111,452,080 (GRCm39)	V113A	probably damaging	Het
Or7h8	T	C	9: 20,123,798 (GRCm39)	I51T	probably benign	Het
Pars2	C	T	4: 106,510,628 (GRCm39)	L128F	probably damaging	Het
Pcsk6	G	T	7: 65,629,996 (GRCm39)	R374L	probably damaging	Het
Ptpn3	T	C	4: 57,270,088 (GRCm39)	T25A	probably benign	Het
Rab11fip1	G	A	8: 27,633,257 (GRCm39)	P1150S	probably damaging	Het
Rabep1	A	G	11: 70,831,212 (GRCm39)	Q831R	possibly damaging	Het
Rad17	T	C	13: 100,786,253 (GRCm39)		probably benign	Het
Rxfp1	T	A	3: 79,557,898 (GRCm39)	R527*	probably null	Het
Scnn1b	C	T	7: 121,502,100 (GRCm39)	P253S	probably damaging	Het
Skic2	G	A	17: 35,064,166 (GRCm39)	R507*	probably null	Het
Slc2a7	T	C	4: 150,242,605 (GRCm39)	F231S	probably damaging	Het
Svil	A	G	18: 5,049,311 (GRCm39)	N196S	probably benign	Het
Tent5c	T	A	3: 100,380,273 (GRCm39)	N161I	probably benign	Het
Urb1	T	C	16: 90,575,971 (GRCm39)	S862G	possibly damaging	Het
Usp30	T	C	5: 114,241,770 (GRCm39)	S87P	probably damaging	Het
Vmn1r177	T	A	7: 23,565,237 (GRCm39)	H213L	probably damaging	Het
Vmn2r120	T	A	17: 57,832,012 (GRCm39)	D259V	probably benign	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20,497,837 (GRCm39)	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20,488,344 (GRCm39)	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20,488,423 (GRCm39)	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20,499,361 (GRCm39)	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- CTTGAAGAACAAATGCCACAACTTAGG -3'
(R):5'- GGTTGGTCTCATCCTTCCAG -3'

Sequencing Primer
(F):5'- CTGTTTGAATGAAATTGGTGAACTC -3'
(R):5'- TTCCAGATGACCACAAAGGG -3'

Posted On

2018-08-01