Incidental Mutation 'R6730:Vmn2r120'
ID 530038
Institutional Source Beutler Lab
Gene Symbol Vmn2r120
Ensembl Gene ENSMUSG00000090655
Gene Name vomeronasal 2, receptor 120
Synonyms EG224916
MMRRC Submission 044848-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6730 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 57815783-57852314 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 57832012 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 259 (D259V)
Ref Sequence ENSEMBL: ENSMUSP00000129296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165781]
AlphaFold A0A3Q4EG79
Predicted Effect probably benign
Transcript: ENSMUST00000165781
AA Change: D259V

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: D259V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 80 474 5.9e-42 PFAM
Pfam:NCD3G 517 570 7.5e-22 PFAM
Pfam:7tm_3 598 836 1.3e-54 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency 100% (44/44)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930455H04Rik T A 3: 116,777,124 (GRCm39) *59R probably null Het
Adam10 G T 9: 70,647,458 (GRCm39) probably null Het
Adam2 A T 14: 66,275,025 (GRCm39) N569K possibly damaging Het
Adam20 T C 8: 41,249,696 (GRCm39) V602A probably benign Het
Adgrb3 T C 1: 25,133,375 (GRCm39) Y1237C probably damaging Het
Ago3 T C 4: 126,265,338 (GRCm39) T318A probably null Het
Aknad1 G A 3: 108,659,655 (GRCm39) G223D possibly damaging Het
Camkv T C 9: 107,825,516 (GRCm39) S478P possibly damaging Het
Ccl27a T A 4: 41,773,342 (GRCm39) H39L probably damaging Het
Ccser2 C A 14: 36,601,043 (GRCm39) S447I probably damaging Het
Clvs2 A G 10: 33,404,517 (GRCm39) L233P probably damaging Het
Csn1s2b T A 5: 87,970,127 (GRCm39) H124Q probably benign Het
Dnhd1 T C 7: 105,353,082 (GRCm39) L2745P probably benign Het
Dync1i2 T A 2: 71,077,484 (GRCm39) F219L probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Ephb6 C T 6: 41,594,308 (GRCm39) Q613* probably null Het
Erc2 A C 14: 27,620,524 (GRCm39) D50A possibly damaging Het
Fam149a T A 8: 45,834,211 (GRCm39) D196V probably damaging Het
Ficd T C 5: 113,876,773 (GRCm39) V316A probably damaging Het
Gstm6 T A 3: 107,850,041 (GRCm39) K18* probably null Het
Ighv1-62-1 A T 12: 115,350,512 (GRCm39) W52R probably benign Het
Klhl18 C T 9: 110,257,979 (GRCm39) C417Y probably damaging Het
Ly9 T A 1: 171,432,737 (GRCm39) Y92F probably benign Het
Mettl18 C T 1: 163,824,750 (GRCm39) T357I probably damaging Het
Myoz2 C A 3: 122,810,276 (GRCm39) G100C probably damaging Het
Or10a49 A T 7: 108,467,780 (GRCm39) F194I probably benign Het
Or4k47 A G 2: 111,452,080 (GRCm39) V113A probably damaging Het
Or7h8 T C 9: 20,123,798 (GRCm39) I51T probably benign Het
Pars2 C T 4: 106,510,628 (GRCm39) L128F probably damaging Het
Pcsk6 G T 7: 65,629,996 (GRCm39) R374L probably damaging Het
Ptpn3 T C 4: 57,270,088 (GRCm39) T25A probably benign Het
Rab11fip1 G A 8: 27,633,257 (GRCm39) P1150S probably damaging Het
Rabep1 A G 11: 70,831,212 (GRCm39) Q831R possibly damaging Het
Rad17 T C 13: 100,786,253 (GRCm39) probably benign Het
Rxfp1 T A 3: 79,557,898 (GRCm39) R527* probably null Het
Scnn1b C T 7: 121,502,100 (GRCm39) P253S probably damaging Het
Skic2 G A 17: 35,064,166 (GRCm39) R507* probably null Het
Slc2a7 T C 4: 150,242,605 (GRCm39) F231S probably damaging Het
Svil A G 18: 5,049,311 (GRCm39) N196S probably benign Het
Tent5c T A 3: 100,380,273 (GRCm39) N161I probably benign Het
Urb1 T C 16: 90,575,971 (GRCm39) S862G possibly damaging Het
Usp30 T C 5: 114,241,770 (GRCm39) S87P probably damaging Het
Vmn1r177 T A 7: 23,565,237 (GRCm39) H213L probably damaging Het
Vmn2r106 T A 17: 20,499,096 (GRCm39) I272L possibly damaging Het
Other mutations in Vmn2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01335:Vmn2r120 APN 17 57,832,732 (GRCm39) missense possibly damaging 0.86
IGL01346:Vmn2r120 APN 17 57,852,232 (GRCm39) missense probably benign 0.11
IGL01996:Vmn2r120 APN 17 57,832,222 (GRCm39) missense possibly damaging 0.92
IGL02503:Vmn2r120 APN 17 57,816,385 (GRCm39) missense probably benign 0.40
IGL02582:Vmn2r120 APN 17 57,831,724 (GRCm39) missense probably damaging 0.99
IGL02747:Vmn2r120 APN 17 57,831,719 (GRCm39) missense probably benign 0.19
IGL02896:Vmn2r120 APN 17 57,816,008 (GRCm39) missense probably damaging 1.00
IGL03139:Vmn2r120 APN 17 57,831,742 (GRCm39) missense probably benign 0.39
IGL03342:Vmn2r120 APN 17 57,816,372 (GRCm39) missense probably benign 0.03
A4554:Vmn2r120 UTSW 17 57,832,715 (GRCm39) missense probably benign 0.01
R0207:Vmn2r120 UTSW 17 57,832,052 (GRCm39) missense probably benign 0.17
R0472:Vmn2r120 UTSW 17 57,831,518 (GRCm39) missense probably benign 0.03
R0517:Vmn2r120 UTSW 17 57,815,949 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r120 UTSW 17 57,832,829 (GRCm39) missense probably benign 0.09
R1316:Vmn2r120 UTSW 17 57,832,939 (GRCm39) missense probably benign 0.28
R1543:Vmn2r120 UTSW 17 57,829,374 (GRCm39) missense probably benign 0.09
R1795:Vmn2r120 UTSW 17 57,832,038 (GRCm39) missense probably benign 0.35
R1850:Vmn2r120 UTSW 17 57,832,826 (GRCm39) missense probably benign 0.19
R1920:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1921:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R1922:Vmn2r120 UTSW 17 57,831,839 (GRCm39) missense probably benign 0.01
R2063:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2064:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2065:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2067:Vmn2r120 UTSW 17 57,831,553 (GRCm39) missense possibly damaging 0.88
R2286:Vmn2r120 UTSW 17 57,815,958 (GRCm39) missense probably damaging 1.00
R2291:Vmn2r120 UTSW 17 57,816,479 (GRCm39) missense probably damaging 1.00
R3416:Vmn2r120 UTSW 17 57,816,241 (GRCm39) missense possibly damaging 0.89
R3874:Vmn2r120 UTSW 17 57,831,954 (GRCm39) missense probably benign 0.40
R4023:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4024:Vmn2r120 UTSW 17 57,843,718 (GRCm39) missense possibly damaging 0.92
R4348:Vmn2r120 UTSW 17 57,829,466 (GRCm39) missense possibly damaging 0.47
R4409:Vmn2r120 UTSW 17 57,816,477 (GRCm39) missense probably damaging 1.00
R4610:Vmn2r120 UTSW 17 57,816,120 (GRCm39) missense probably damaging 1.00
R4771:Vmn2r120 UTSW 17 57,831,887 (GRCm39) missense probably damaging 1.00
R4786:Vmn2r120 UTSW 17 57,829,048 (GRCm39) missense probably benign 0.14
R4927:Vmn2r120 UTSW 17 57,816,125 (GRCm39) missense probably damaging 1.00
R5285:Vmn2r120 UTSW 17 57,843,703 (GRCm39) missense probably damaging 1.00
R5566:Vmn2r120 UTSW 17 57,852,290 (GRCm39) missense possibly damaging 0.95
R5578:Vmn2r120 UTSW 17 57,829,514 (GRCm39) missense probably benign 0.01
R5643:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5644:Vmn2r120 UTSW 17 57,831,977 (GRCm39) missense probably benign 0.01
R5781:Vmn2r120 UTSW 17 57,831,938 (GRCm39) missense probably benign 0.00
R6084:Vmn2r120 UTSW 17 57,832,721 (GRCm39) missense probably benign 0.15
R6120:Vmn2r120 UTSW 17 57,832,973 (GRCm39) missense probably benign 0.02
R6160:Vmn2r120 UTSW 17 57,816,418 (GRCm39) missense probably benign 0.03
R6248:Vmn2r120 UTSW 17 57,852,287 (GRCm39) missense probably benign 0.03
R6256:Vmn2r120 UTSW 17 57,831,700 (GRCm39) nonsense probably null
R6821:Vmn2r120 UTSW 17 57,843,659 (GRCm39) missense probably benign 0.00
R6868:Vmn2r120 UTSW 17 57,852,218 (GRCm39) missense probably benign 0.00
R6880:Vmn2r120 UTSW 17 57,816,187 (GRCm39) missense probably damaging 1.00
R6986:Vmn2r120 UTSW 17 57,816,340 (GRCm39) missense probably damaging 1.00
R7276:Vmn2r120 UTSW 17 57,831,881 (GRCm39) missense probably benign 0.11
R7373:Vmn2r120 UTSW 17 57,816,406 (GRCm39) missense probably benign 0.35
R7653:Vmn2r120 UTSW 17 57,816,258 (GRCm39) missense possibly damaging 0.93
R7667:Vmn2r120 UTSW 17 57,843,657 (GRCm39) missense probably benign 0.04
R7775:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7778:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7797:Vmn2r120 UTSW 17 57,815,874 (GRCm39) missense probably damaging 1.00
R7824:Vmn2r120 UTSW 17 57,832,942 (GRCm39) missense probably damaging 1.00
R7902:Vmn2r120 UTSW 17 57,816,244 (GRCm39) missense possibly damaging 0.87
R7922:Vmn2r120 UTSW 17 57,831,683 (GRCm39) missense probably damaging 0.99
R8508:Vmn2r120 UTSW 17 57,832,843 (GRCm39) missense probably benign 0.03
R8847:Vmn2r120 UTSW 17 57,816,217 (GRCm39) missense probably benign 0.01
R8882:Vmn2r120 UTSW 17 57,852,229 (GRCm39) missense probably benign 0.01
R9134:Vmn2r120 UTSW 17 57,832,093 (GRCm39) missense probably damaging 1.00
R9161:Vmn2r120 UTSW 17 57,831,864 (GRCm39) missense
R9336:Vmn2r120 UTSW 17 57,832,201 (GRCm39) missense possibly damaging 0.91
RF005:Vmn2r120 UTSW 17 57,828,991 (GRCm39) missense possibly damaging 0.65
Z1177:Vmn2r120 UTSW 17 57,816,245 (GRCm39) missense probably benign 0.00
Z1188:Vmn2r120 UTSW 17 57,829,436 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCAGGATGAAATGTCTTACACTGC -3'
(R):5'- GATCCAATGCTTAGTGACCATG -3'

Sequencing Primer
(F):5'- TGCTAGCAATATCCCACTGTGAGG -3'
(R):5'- CCAATGCTTAGTGACCATGTGAAG -3'
Posted On 2018-08-01