Mutagenetix > Incidental Mutation

Incidental Mutation 'R6730:Vmn2r120'

530038

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

044848-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R6730 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57508783-57545314 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 57525012 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 259 (D259V)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably benign
Transcript: ENSMUST00000165781
AA Change: D259V

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: D259V

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.1%
20x: 94.5%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930455H04Rik	T	A	3: 116,983,475 (GRCm38)	*59R	probably null	Het
Adam10	G	T	9: 70,740,176 (GRCm38)		probably null	Het
Adam2	A	T	14: 66,037,576 (GRCm38)	N569K	possibly damaging	Het
Adam20	T	C	8: 40,796,659 (GRCm38)	V602A	probably benign	Het
Adgrb3	T	C	1: 25,094,294 (GRCm38)	Y1237C	probably damaging	Het
Ago3	T	C	4: 126,371,545 (GRCm38)	T318A	probably null	Het
Aknad1	G	A	3: 108,752,339 (GRCm38)	G223D	possibly damaging	Het
Camkv	T	C	9: 107,948,317 (GRCm38)	S478P	possibly damaging	Het
Ccl27a	T	A	4: 41,773,342 (GRCm38)	H39L	probably damaging	Het
Ccser2	C	A	14: 36,879,086 (GRCm38)	S447I	probably damaging	Het
Clvs2	A	G	10: 33,528,521 (GRCm38)	L233P	probably damaging	Het
Csn1s2b	T	A	5: 87,822,268 (GRCm38)	H124Q	probably benign	Het
Dnhd1	T	C	7: 105,703,875 (GRCm38)	L2745P	probably benign	Het
Dync1i2	T	A	2: 71,247,140 (GRCm38)	F219L	probably benign	Het
Eml2	G	A	7: 19,201,163 (GRCm38)	V432I	probably damaging	Het
Ephb6	C	T	6: 41,617,374 (GRCm38)	Q613*	probably null	Het
Erc2	A	C	14: 27,898,567 (GRCm38)	D50A	possibly damaging	Het
Fam149a	T	A	8: 45,381,174 (GRCm38)	D196V	probably damaging	Het
Ficd	T	C	5: 113,738,712 (GRCm38)	V316A	probably damaging	Het
Gstm6	T	A	3: 107,942,725 (GRCm38)	K18*	probably null	Het
Ighv1-62-1	A	T	12: 115,386,892 (GRCm38)	W52R	probably benign	Het
Klhl18	C	T	9: 110,428,911 (GRCm38)	C417Y	probably damaging	Het
Ly9	T	A	1: 171,605,169 (GRCm38)	Y92F	probably benign	Het
Mettl18	C	T	1: 163,997,181 (GRCm38)	T357I	probably damaging	Het
Myoz2	C	A	3: 123,016,627 (GRCm38)	G100C	probably damaging	Het
Or10a49	A	T	7: 108,868,573 (GRCm38)	F194I	probably benign	Het
Or4k47	A	G	2: 111,621,735 (GRCm38)	V113A	probably damaging	Het
Or7h8	T	C	9: 20,212,502 (GRCm38)	I51T	probably benign	Het
Pars2	C	T	4: 106,653,431 (GRCm38)	L128F	probably damaging	Het
Pcsk6	G	T	7: 65,980,248 (GRCm38)	R374L	probably damaging	Het
Ptpn3	T	C	4: 57,270,088 (GRCm38)	T25A	probably benign	Het
Rab11fip1	G	A	8: 27,143,229 (GRCm38)	P1150S	probably damaging	Het
Rabep1	A	G	11: 70,940,386 (GRCm38)	Q831R	possibly damaging	Het
Rad17	T	C	13: 100,649,745 (GRCm38)		probably benign	Het
Rxfp1	T	A	3: 79,650,591 (GRCm38)	R527*	probably null	Het
Scnn1b	C	T	7: 121,902,877 (GRCm38)	P253S	probably damaging	Het
Skic2	G	A	17: 34,845,190 (GRCm38)	R507*	probably null	Het
Slc2a7	T	C	4: 150,158,148 (GRCm38)	F231S	probably damaging	Het
Svil	A	G	18: 5,049,311 (GRCm38)	N196S	probably benign	Het
Tent5c	T	A	3: 100,472,957 (GRCm38)	N161I	probably benign	Het
Urb1	T	C	16: 90,779,083 (GRCm38)	S862G	possibly damaging	Het
Usp30	T	C	5: 114,103,709 (GRCm38)	S87P	probably damaging	Het
Vmn1r177	T	A	7: 23,865,812 (GRCm38)	H213L	probably damaging	Het
Vmn2r106	T	A	17: 20,278,834 (GRCm38)	I272L	possibly damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57,525,732 (GRCm38)	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57,545,232 (GRCm38)	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57,525,222 (GRCm38)	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57,509,385 (GRCm38)	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57,524,724 (GRCm38)	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57,524,719 (GRCm38)	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57,509,008 (GRCm38)	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57,524,742 (GRCm38)	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57,509,372 (GRCm38)	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57,525,715 (GRCm38)	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57,525,052 (GRCm38)	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57,524,518 (GRCm38)	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57,508,949 (GRCm38)	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57,525,829 (GRCm38)	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57,525,939 (GRCm38)	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57,522,374 (GRCm38)	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57,525,038 (GRCm38)	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57,525,826 (GRCm38)	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57,524,839 (GRCm38)	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57,524,839 (GRCm38)	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57,524,839 (GRCm38)	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57,524,553 (GRCm38)	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57,524,553 (GRCm38)	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57,524,553 (GRCm38)	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57,524,553 (GRCm38)	missense	possibly damaging	0.88
R2286:Vmn2r120	UTSW	17	57,508,958 (GRCm38)	missense	probably damaging	1.00
R2291:Vmn2r120	UTSW	17	57,509,479 (GRCm38)	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57,509,241 (GRCm38)	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57,524,954 (GRCm38)	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57,536,718 (GRCm38)	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57,536,718 (GRCm38)	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57,522,466 (GRCm38)	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57,509,477 (GRCm38)	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57,509,120 (GRCm38)	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57,524,887 (GRCm38)	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57,522,048 (GRCm38)	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57,509,125 (GRCm38)	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57,536,703 (GRCm38)	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57,545,290 (GRCm38)	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57,522,514 (GRCm38)	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57,524,977 (GRCm38)	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57,524,977 (GRCm38)	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57,524,938 (GRCm38)	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57,525,721 (GRCm38)	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57,525,973 (GRCm38)	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57,509,418 (GRCm38)	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57,545,287 (GRCm38)	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57,524,700 (GRCm38)	nonsense	probably null
R6821:Vmn2r120	UTSW	17	57,536,659 (GRCm38)	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57,545,218 (GRCm38)	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57,509,187 (GRCm38)	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57,509,340 (GRCm38)	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57,524,881 (GRCm38)	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57,509,406 (GRCm38)	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57,509,258 (GRCm38)	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57,536,657 (GRCm38)	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57,525,942 (GRCm38)	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57,525,942 (GRCm38)	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57,508,874 (GRCm38)	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57,525,942 (GRCm38)	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57,509,244 (GRCm38)	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57,524,683 (GRCm38)	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57,525,843 (GRCm38)	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57,509,217 (GRCm38)	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57,545,229 (GRCm38)	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57,525,093 (GRCm38)	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57,524,864 (GRCm38)	missense
R9336:Vmn2r120	UTSW	17	57,525,201 (GRCm38)	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57,521,991 (GRCm38)	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57,509,245 (GRCm38)	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57,522,436 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCAGGATGAAATGTCTTACACTGC -3'
(R):5'- GATCCAATGCTTAGTGACCATG -3'

Sequencing Primer
(F):5'- TGCTAGCAATATCCCACTGTGAGG -3'
(R):5'- CCAATGCTTAGTGACCATGTGAAG -3'

Posted On

2018-08-01