Incidental Mutation 'R6733:Zscan25'
ID 530136
Institutional Source Beutler Lab
Gene Symbol Zscan25
Ensembl Gene ENSMUSG00000070420
Gene Name zinc finger and SCAN domain containing 25
Synonyms Zfp498, EG666311
MMRRC Submission 044851-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.151) question?
Stock # R6733 (G1)
Quality Score 189.009
Status Not validated
Chromosome 5
Chromosomal Location 145217310-145228088 bp(+) (GRCm39)
Type of Mutation splice site (4451 bp from exon)
DNA Base Change (assembly) T to A at 145227723 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142367 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094116] [ENSMUST00000199563] [ENSMUST00000200246]
AlphaFold B2RX31
Predicted Effect probably null
Transcript: ENSMUST00000094116
AA Change: C462*
SMART Domains Protein: ENSMUSP00000091664
Gene: ENSMUSG00000070420
AA Change: C462*

DomainStartEndE-ValueType
SCAN 38 150 5.94e-53 SMART
Blast:KRAB 231 288 4e-31 BLAST
ZnF_C2H2 346 368 2.15e-5 SMART
ZnF_C2H2 374 396 5.06e-2 SMART
ZnF_C2H2 402 424 8.34e-3 SMART
ZnF_C2H2 430 452 3.39e-3 SMART
ZnF_C2H2 458 479 1.08e1 SMART
ZnF_C2H2 485 507 4.47e-3 SMART
ZnF_C2H2 513 536 5.59e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197174
Predicted Effect probably benign
Transcript: ENSMUST00000199563
SMART Domains Protein: ENSMUSP00000143449
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 2.1e-54 SMART
Predicted Effect probably null
Transcript: ENSMUST00000200246
SMART Domains Protein: ENSMUSP00000142367
Gene: ENSMUSG00000070420

DomainStartEndE-ValueType
SCAN 38 150 1.9e-55 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afdn C T 17: 14,043,615 (GRCm39) H358Y probably benign Het
Aoc1l2 T C 6: 48,907,464 (GRCm39) S155P probably damaging Het
Ccdc125 T A 13: 100,830,995 (GRCm39) M394K probably benign Het
Cfd C A 10: 79,727,636 (GRCm39) H103Q probably damaging Het
Cnot2 G A 10: 116,334,058 (GRCm39) P371S possibly damaging Het
Dedd2 T C 7: 24,903,332 (GRCm39) E209G probably benign Het
Dnah3 A G 7: 119,522,197 (GRCm39) S3999P probably benign Het
Fer1l5 T C 1: 36,447,753 (GRCm39) probably null Het
H6pd A T 4: 150,069,578 (GRCm39) probably null Het
Il25 T C 14: 55,170,490 (GRCm39) I21T probably benign Het
Kmt2c C T 5: 25,614,291 (GRCm39) S143N probably damaging Het
Marveld3 T C 8: 110,688,681 (GRCm39) D20G possibly damaging Het
Msl1 A G 11: 98,690,882 (GRCm39) E122G probably damaging Het
Obscn A T 11: 58,919,421 (GRCm39) V6861E probably damaging Het
Or5b97 A T 19: 12,878,605 (GRCm39) C180S probably damaging Het
Phc1 A T 6: 122,313,845 (GRCm39) M29K possibly damaging Het
Pkd1l3 T A 8: 110,375,126 (GRCm39) probably null Het
Prl5a1 G T 13: 28,333,919 (GRCm39) V141F possibly damaging Het
Psg20 A T 7: 18,408,547 (GRCm39) V391D probably damaging Het
Ptprh T C 7: 4,606,043 (GRCm39) probably null Het
Rasa3 T C 8: 13,630,037 (GRCm39) E580G possibly damaging Het
Ror1 T C 4: 100,283,252 (GRCm39) V439A probably benign Het
Rsl1 A G 13: 67,325,206 (GRCm39) T81A probably benign Het
Sgpp1 G C 12: 75,782,243 (GRCm39) P32R probably benign Het
Slc22a8 T C 19: 8,586,656 (GRCm39) L389P probably benign Het
Slc6a11 A G 6: 114,111,859 (GRCm39) Y142C probably damaging Het
Syt9 C T 7: 107,024,503 (GRCm39) T132I probably damaging Het
Thop1 T A 10: 80,917,246 (GRCm39) I583N probably damaging Het
Tom1l1 A G 11: 90,575,886 (GRCm39) probably null Het
Unk A G 11: 115,941,581 (GRCm39) D276G probably damaging Het
Zfp942 C A 17: 22,147,733 (GRCm39) E299* probably null Het
Zkscan6 A G 11: 65,719,461 (GRCm39) T494A probably damaging Het
Other mutations in Zscan25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00309:Zscan25 APN 5 145,220,559 (GRCm39) missense probably damaging 1.00
IGL02622:Zscan25 APN 5 145,227,512 (GRCm39) missense probably damaging 1.00
IGL02881:Zscan25 APN 5 145,227,296 (GRCm39) missense probably benign 0.25
PIT4445001:Zscan25 UTSW 5 145,227,422 (GRCm39) missense probably damaging 1.00
R1713:Zscan25 UTSW 5 145,220,501 (GRCm39) missense probably damaging 0.99
R1828:Zscan25 UTSW 5 145,227,858 (GRCm39) missense possibly damaging 0.95
R2233:Zscan25 UTSW 5 145,220,502 (GRCm39) missense probably damaging 1.00
R3882:Zscan25 UTSW 5 145,227,862 (GRCm39) missense probably damaging 1.00
R4330:Zscan25 UTSW 5 145,227,361 (GRCm39) missense probably damaging 0.99
R4527:Zscan25 UTSW 5 145,220,268 (GRCm39) missense probably damaging 1.00
R4539:Zscan25 UTSW 5 145,225,201 (GRCm39) missense probably benign 0.01
R4598:Zscan25 UTSW 5 145,227,815 (GRCm39) missense probably benign 0.30
R4611:Zscan25 UTSW 5 145,227,926 (GRCm39) missense probably damaging 1.00
R4662:Zscan25 UTSW 5 145,223,120 (GRCm39) missense unknown
R6751:Zscan25 UTSW 5 145,227,373 (GRCm39) missense probably damaging 1.00
R7161:Zscan25 UTSW 5 145,223,251 (GRCm39) missense probably benign 0.00
R7912:Zscan25 UTSW 5 145,227,321 (GRCm39) missense probably benign 0.00
R8746:Zscan25 UTSW 5 145,224,157 (GRCm39) missense possibly damaging 0.81
R8936:Zscan25 UTSW 5 145,223,200 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGCTGGAAGACCTTCAGC -3'
(R):5'- TTAGTAGGCTCACTGCACCG -3'

Sequencing Primer
(F):5'- CTGGAAGACCTTCAGCCAGAG -3'
(R):5'- ACCTCTGGTTGAAGCTGC -3'
Posted On 2018-08-01