|Institutional Source||Beutler Lab|
|Gene Name||C-type lectin domain family 4, member g|
|Is this an essential gene?||Probably non essential (E-score: 0.050)|
|Stock #||R6737 (G1)|
|Chromosomal Location||3707064-3720651 bp(-) (GRCm38)|
|Type of Mutation||utr 3 prime|
|DNA Base Change (assembly)||T to C at 3707716 bp|
|Amino Acid Change|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000058040]|
AA Change: R78G
|Predicted Effect||noncoding transcript
|Predicted Effect||probably benign
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Clec4g||
(F):5'- ATCCTTTAGTTCATACTGGGGAGG -3'
(R):5'- TCTCCCTGGAAATGGCCTTG -3'
(F):5'- TAGTTCATACTGGGGAGGTAAATAC -3'
(R):5'- CTCCCTGGAAATGGCCTTGAGATAG -3'