Incidental Mutation 'R6738:Vmn2r109'
ID |
530337 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r109
|
Ensembl Gene |
ENSMUSG00000090572 |
Gene Name |
vomeronasal 2, receptor 109 |
Synonyms |
EG627814 |
MMRRC Submission |
044856-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.069)
|
Stock # |
R6738 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
20760779-20785018 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 20774785 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Leucine
at position 190
(S190L)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
AlphaFold |
K7N747 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167093
AA Change: S190L
PolyPhen 2
Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000132641 Gene: ENSMUSG00000090572 AA Change: S190L
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.2%
|
Validation Efficiency |
100% (55/55) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 55 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abat |
C |
T |
16: 8,420,300 (GRCm39) |
|
probably benign |
Het |
Abl1 |
T |
C |
2: 31,684,586 (GRCm39) |
Y454H |
probably damaging |
Het |
Ambp |
A |
T |
4: 63,067,711 (GRCm39) |
D166E |
probably benign |
Het |
Amigo2 |
A |
G |
15: 97,143,345 (GRCm39) |
V359A |
possibly damaging |
Het |
Ankrd11 |
A |
T |
8: 123,618,660 (GRCm39) |
S1710T |
probably damaging |
Het |
Ankrd31 |
T |
C |
13: 97,040,635 (GRCm39) |
S1713P |
possibly damaging |
Het |
Arhgap45 |
A |
T |
10: 79,863,431 (GRCm39) |
K758M |
probably damaging |
Het |
Bclaf1 |
T |
C |
10: 20,199,515 (GRCm39) |
I304T |
possibly damaging |
Het |
C1ra |
A |
G |
6: 124,494,718 (GRCm39) |
Y327C |
probably damaging |
Het |
Ccdc73 |
C |
T |
2: 104,822,433 (GRCm39) |
S794L |
probably benign |
Het |
Cd24a |
A |
G |
10: 43,458,672 (GRCm39) |
N48D |
possibly damaging |
Het |
Col11a1 |
A |
G |
3: 113,906,116 (GRCm39) |
|
probably benign |
Het |
Cyp11b2 |
G |
A |
15: 74,725,363 (GRCm39) |
T252I |
possibly damaging |
Het |
Dlx2 |
A |
G |
2: 71,376,406 (GRCm39) |
Y111H |
probably benign |
Het |
Dsp |
T |
C |
13: 38,376,186 (GRCm39) |
S1324P |
possibly damaging |
Het |
Esyt3 |
A |
T |
9: 99,202,346 (GRCm39) |
F522I |
probably damaging |
Het |
Fam193b |
C |
T |
13: 55,698,174 (GRCm39) |
A45T |
probably benign |
Het |
Flnb |
A |
G |
14: 7,904,536 (GRCm38) |
T980A |
probably benign |
Het |
Gabrb2 |
G |
T |
11: 42,484,758 (GRCm39) |
A272S |
possibly damaging |
Het |
H2al2a |
G |
T |
2: 18,001,429 (GRCm39) |
Q86K |
possibly damaging |
Het |
Ikbkb |
T |
G |
8: 23,165,052 (GRCm39) |
I243L |
probably damaging |
Het |
Il18r1 |
A |
G |
1: 40,537,816 (GRCm39) |
E527G |
probably benign |
Het |
Krt35 |
A |
T |
11: 99,984,535 (GRCm39) |
V320D |
probably damaging |
Het |
Krt76 |
C |
T |
15: 101,795,913 (GRCm39) |
R419H |
probably benign |
Het |
Lrp2 |
T |
A |
2: 69,288,832 (GRCm39) |
Y3678F |
probably damaging |
Het |
Mab21l4 |
G |
A |
1: 93,087,707 (GRCm39) |
L49F |
probably benign |
Het |
Mnat1 |
T |
G |
12: 73,319,246 (GRCm39) |
S290A |
probably benign |
Het |
Mptx2 |
T |
C |
1: 173,102,422 (GRCm39) |
E89G |
probably benign |
Het |
Myom1 |
T |
A |
17: 71,407,393 (GRCm39) |
|
probably null |
Het |
Naaladl2 |
A |
G |
3: 24,225,806 (GRCm39) |
V541A |
probably benign |
Het |
Nbeal2 |
T |
C |
9: 110,465,973 (GRCm39) |
T851A |
possibly damaging |
Het |
Ncoa4 |
A |
G |
14: 31,892,750 (GRCm39) |
Y11C |
probably benign |
Het |
Ntn5 |
T |
A |
7: 45,343,780 (GRCm39) |
|
probably null |
Het |
Or10d4c |
A |
G |
9: 39,557,957 (GRCm39) |
|
probably benign |
Het |
Or1j18 |
C |
T |
2: 36,624,444 (GRCm39) |
T37I |
probably benign |
Het |
Otop2 |
A |
G |
11: 115,220,318 (GRCm39) |
Y386C |
probably damaging |
Het |
Ppp2r1a |
T |
A |
17: 21,174,979 (GRCm39) |
|
probably null |
Het |
Prkd2 |
C |
A |
7: 16,599,830 (GRCm39) |
N764K |
possibly damaging |
Het |
Ralgapa1 |
A |
G |
12: 55,809,512 (GRCm39) |
L421S |
probably damaging |
Het |
Ric3 |
G |
A |
7: 108,647,269 (GRCm39) |
R184* |
probably null |
Het |
Sfswap |
A |
G |
5: 129,618,505 (GRCm39) |
K480E |
probably damaging |
Het |
Siah2 |
A |
G |
3: 58,598,974 (GRCm39) |
V88A |
probably benign |
Het |
Slc22a16 |
T |
C |
10: 40,461,298 (GRCm39) |
F367L |
probably damaging |
Het |
Slc23a2 |
T |
C |
2: 131,920,356 (GRCm39) |
D183G |
probably benign |
Het |
Svep1 |
T |
C |
4: 58,123,180 (GRCm39) |
N712S |
possibly damaging |
Het |
Tex21 |
A |
G |
12: 76,286,283 (GRCm39) |
V72A |
probably benign |
Het |
Tfap4 |
A |
G |
16: 4,367,311 (GRCm39) |
Y184H |
probably damaging |
Het |
Timeless |
T |
C |
10: 128,076,504 (GRCm39) |
Y138H |
probably damaging |
Het |
Tln2 |
A |
T |
9: 67,293,946 (GRCm39) |
N227K |
possibly damaging |
Het |
Trip10 |
C |
T |
17: 57,563,899 (GRCm39) |
P342S |
probably benign |
Het |
Ttc6 |
A |
T |
12: 57,735,426 (GRCm39) |
E1156V |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,728,472 (GRCm39) |
|
probably benign |
Het |
Wdr54 |
A |
G |
6: 83,132,109 (GRCm39) |
S99P |
probably damaging |
Het |
Ythdf2 |
A |
C |
4: 131,932,272 (GRCm39) |
I296R |
probably benign |
Het |
Zfp445 |
A |
G |
9: 122,691,123 (GRCm39) |
V24A |
probably damaging |
Het |
|
Other mutations in Vmn2r109 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01313:Vmn2r109
|
APN |
17 |
20,770,419 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01383:Vmn2r109
|
APN |
17 |
20,761,383 (GRCm39) |
missense |
possibly damaging |
0.89 |
IGL01469:Vmn2r109
|
APN |
17 |
20,761,671 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01762:Vmn2r109
|
APN |
17 |
20,774,654 (GRCm39) |
missense |
probably benign |
|
IGL01864:Vmn2r109
|
APN |
17 |
20,761,396 (GRCm39) |
missense |
probably benign |
0.28 |
IGL02028:Vmn2r109
|
APN |
17 |
20,761,342 (GRCm39) |
missense |
probably benign |
0.28 |
IGL02074:Vmn2r109
|
APN |
17 |
20,774,603 (GRCm39) |
missense |
probably benign |
0.05 |
IGL02162:Vmn2r109
|
APN |
17 |
20,774,422 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02474:Vmn2r109
|
APN |
17 |
20,761,150 (GRCm39) |
missense |
probably benign |
|
IGL02490:Vmn2r109
|
APN |
17 |
20,761,246 (GRCm39) |
missense |
possibly damaging |
0.78 |
IGL02604:Vmn2r109
|
APN |
17 |
20,760,963 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02669:Vmn2r109
|
APN |
17 |
20,774,518 (GRCm39) |
missense |
possibly damaging |
0.64 |
IGL02705:Vmn2r109
|
APN |
17 |
20,774,062 (GRCm39) |
missense |
probably benign |
|
IGL02745:Vmn2r109
|
APN |
17 |
20,761,512 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,774,839 (GRCm39) |
critical splice acceptor site |
probably null |
|
R0389:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
R0470:Vmn2r109
|
UTSW |
17 |
20,773,148 (GRCm39) |
missense |
probably benign |
0.06 |
R0570:Vmn2r109
|
UTSW |
17 |
20,760,937 (GRCm39) |
missense |
probably damaging |
0.99 |
R0855:Vmn2r109
|
UTSW |
17 |
20,761,670 (GRCm39) |
nonsense |
probably null |
|
R0882:Vmn2r109
|
UTSW |
17 |
20,774,842 (GRCm39) |
splice site |
probably benign |
|
R1241:Vmn2r109
|
UTSW |
17 |
20,775,503 (GRCm39) |
missense |
possibly damaging |
0.86 |
R1587:Vmn2r109
|
UTSW |
17 |
20,761,002 (GRCm39) |
missense |
probably damaging |
1.00 |
R1931:Vmn2r109
|
UTSW |
17 |
20,774,072 (GRCm39) |
nonsense |
probably null |
|
R1957:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
R1962:Vmn2r109
|
UTSW |
17 |
20,774,185 (GRCm39) |
missense |
probably damaging |
0.99 |
R2020:Vmn2r109
|
UTSW |
17 |
20,761,448 (GRCm39) |
nonsense |
probably null |
|
R2073:Vmn2r109
|
UTSW |
17 |
20,784,974 (GRCm39) |
missense |
probably benign |
0.00 |
R2436:Vmn2r109
|
UTSW |
17 |
20,774,798 (GRCm39) |
missense |
probably damaging |
0.99 |
R3123:Vmn2r109
|
UTSW |
17 |
20,761,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R3839:Vmn2r109
|
UTSW |
17 |
20,774,704 (GRCm39) |
missense |
probably damaging |
1.00 |
R4019:Vmn2r109
|
UTSW |
17 |
20,774,074 (GRCm39) |
missense |
probably benign |
|
R4428:Vmn2r109
|
UTSW |
17 |
20,773,286 (GRCm39) |
missense |
probably benign |
|
R4584:Vmn2r109
|
UTSW |
17 |
20,774,820 (GRCm39) |
nonsense |
probably null |
|
R4652:Vmn2r109
|
UTSW |
17 |
20,761,656 (GRCm39) |
missense |
probably damaging |
1.00 |
R4708:Vmn2r109
|
UTSW |
17 |
20,761,605 (GRCm39) |
missense |
probably damaging |
0.97 |
R4823:Vmn2r109
|
UTSW |
17 |
20,774,153 (GRCm39) |
missense |
probably damaging |
1.00 |
R4831:Vmn2r109
|
UTSW |
17 |
20,761,494 (GRCm39) |
missense |
probably benign |
0.01 |
R4907:Vmn2r109
|
UTSW |
17 |
20,770,348 (GRCm39) |
missense |
probably damaging |
1.00 |
R5011:Vmn2r109
|
UTSW |
17 |
20,775,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R5296:Vmn2r109
|
UTSW |
17 |
20,774,603 (GRCm39) |
missense |
possibly damaging |
0.90 |
R5600:Vmn2r109
|
UTSW |
17 |
20,761,189 (GRCm39) |
missense |
probably damaging |
1.00 |
R5602:Vmn2r109
|
UTSW |
17 |
20,760,933 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5652:Vmn2r109
|
UTSW |
17 |
20,760,781 (GRCm39) |
makesense |
probably null |
|
R5702:Vmn2r109
|
UTSW |
17 |
20,774,407 (GRCm39) |
missense |
probably benign |
0.42 |
R5706:Vmn2r109
|
UTSW |
17 |
20,774,567 (GRCm39) |
missense |
probably benign |
0.16 |
R5714:Vmn2r109
|
UTSW |
17 |
20,773,121 (GRCm39) |
missense |
probably damaging |
1.00 |
R5832:Vmn2r109
|
UTSW |
17 |
20,761,318 (GRCm39) |
missense |
probably benign |
0.10 |
R6008:Vmn2r109
|
UTSW |
17 |
20,760,981 (GRCm39) |
missense |
probably damaging |
1.00 |
R6334:Vmn2r109
|
UTSW |
17 |
20,761,440 (GRCm39) |
missense |
probably benign |
0.18 |
R6377:Vmn2r109
|
UTSW |
17 |
20,784,796 (GRCm39) |
critical splice donor site |
probably null |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,760,932 (GRCm39) |
missense |
probably benign |
0.45 |
R6953:Vmn2r109
|
UTSW |
17 |
20,760,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7108:Vmn2r109
|
UTSW |
17 |
20,785,006 (GRCm39) |
missense |
probably benign |
0.03 |
R7229:Vmn2r109
|
UTSW |
17 |
20,761,225 (GRCm39) |
missense |
possibly damaging |
0.80 |
R7238:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
R7244:Vmn2r109
|
UTSW |
17 |
20,760,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
R7292:Vmn2r109
|
UTSW |
17 |
20,761,700 (GRCm39) |
missense |
probably benign |
0.05 |
R7354:Vmn2r109
|
UTSW |
17 |
20,761,043 (GRCm39) |
missense |
probably damaging |
1.00 |
R7357:Vmn2r109
|
UTSW |
17 |
20,761,536 (GRCm39) |
missense |
probably damaging |
1.00 |
R7522:Vmn2r109
|
UTSW |
17 |
20,774,665 (GRCm39) |
missense |
probably benign |
0.11 |
R7596:Vmn2r109
|
UTSW |
17 |
20,760,942 (GRCm39) |
missense |
probably damaging |
0.98 |
R7728:Vmn2r109
|
UTSW |
17 |
20,773,117 (GRCm39) |
missense |
probably damaging |
0.99 |
R7859:Vmn2r109
|
UTSW |
17 |
20,761,436 (GRCm39) |
missense |
probably damaging |
1.00 |
R7871:Vmn2r109
|
UTSW |
17 |
20,760,782 (GRCm39) |
missense |
probably benign |
0.08 |
R8113:Vmn2r109
|
UTSW |
17 |
20,774,729 (GRCm39) |
missense |
probably benign |
0.01 |
R8153:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
R8977:Vmn2r109
|
UTSW |
17 |
20,774,531 (GRCm39) |
missense |
possibly damaging |
0.96 |
R9687:Vmn2r109
|
UTSW |
17 |
20,775,332 (GRCm39) |
missense |
|
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,773,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- GTGTCAGGGATCATTTTCACAAAAG -3'
(R):5'- TGAAACTAACAGGTTTGGCAGG -3'
Sequencing Primer
(F):5'- CACAAAAGCTATGCAGATGCCTTTTC -3'
(R):5'- CTAACAGGTTTGGCAGGAATTTC -3'
|
Posted On |
2018-08-01 |