Incidental Mutation 'IGL01086:Clip4'
ID 53034
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clip4
Ensembl Gene ENSMUSG00000024059
Gene Name CAP-GLY domain containing linker protein family, member 4
Synonyms 4833417L20Rik, 1700074B05Rik, 5830409B12Rik, Rsnl2, 1700024K14Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # IGL01086
Quality Score
Status
Chromosome 17
Chromosomal Location 72076674-72171205 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 72131789 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 376 (V376I)
Ref Sequence ENSEMBL: ENSMUSP00000154969 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024854] [ENSMUST00000229304] [ENSMUST00000229874] [ENSMUST00000229952] [ENSMUST00000230747] [ENSMUST00000230305] [ENSMUST00000230749] [ENSMUST00000230333] [ENSMUST00000231105]
AlphaFold Q8CI96
Predicted Effect probably benign
Transcript: ENSMUST00000024854
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000024854
Gene: ENSMUSG00000024059
AA Change: V376I

DomainStartEndE-ValueType
ANK 106 144 4.58e2 SMART
ANK 149 180 3.26e0 SMART
ANK 186 215 3.26e0 SMART
CAP_GLY 285 350 6.63e-34 SMART
low complexity region 358 371 N/A INTRINSIC
low complexity region 389 403 N/A INTRINSIC
low complexity region 423 432 N/A INTRINSIC
low complexity region 440 461 N/A INTRINSIC
low complexity region 469 478 N/A INTRINSIC
CAP_GLY 486 551 5.52e-31 SMART
low complexity region 575 586 N/A INTRINSIC
low complexity region 598 612 N/A INTRINSIC
CAP_GLY 624 690 5.65e-28 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229014
Predicted Effect probably benign
Transcript: ENSMUST00000229304
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000229874
AA Change: V376I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000229952
Predicted Effect unknown
Transcript: ENSMUST00000230160
AA Change: V68I
Predicted Effect probably benign
Transcript: ENSMUST00000230747
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000230305
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000230749
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000230333
AA Change: V376I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230845
Predicted Effect probably benign
Transcript: ENSMUST00000231131
Predicted Effect probably benign
Transcript: ENSMUST00000231105
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,796,729 (GRCm39) R104S probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Aim2 A G 1: 173,282,999 (GRCm39) Y27C probably damaging Het
Apol7b T C 15: 77,308,114 (GRCm39) E127G probably damaging Het
Atp10a T C 7: 58,474,066 (GRCm39) F1118L probably damaging Het
Cacna1e T C 1: 154,347,347 (GRCm39) D940G probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cmklr2 T C 1: 63,222,650 (GRCm39) E195G probably benign Het
Coro6 C A 11: 77,357,374 (GRCm39) C194* probably null Het
Crebbp T C 16: 3,997,416 (GRCm39) M223V probably benign Het
Dkk4 T A 8: 23,116,857 (GRCm39) C157S probably damaging Het
Dnah14 T C 1: 181,579,611 (GRCm39) L3048S probably benign Het
Dscaml1 T C 9: 45,613,960 (GRCm39) probably benign Het
Gria2 T C 3: 80,599,688 (GRCm39) Y732C probably damaging Het
Igkv4-59 T C 6: 69,415,707 (GRCm39) I7V probably benign Het
Lamc3 T C 2: 31,788,488 (GRCm39) F216S probably damaging Het
Lcn6 T C 2: 25,570,792 (GRCm39) F61L probably benign Het
Nup205 T A 6: 35,185,871 (GRCm39) probably benign Het
Or5w18 T A 2: 87,633,544 (GRCm39) Y266* probably null Het
Otof C T 5: 30,533,617 (GRCm39) probably null Het
Pik3c2b T C 1: 133,019,356 (GRCm39) C1035R probably damaging Het
Pla1a T C 16: 38,227,984 (GRCm39) N298D probably benign Het
Poteg T A 8: 27,963,648 (GRCm39) probably benign Het
Pwp1 T C 10: 85,715,757 (GRCm39) probably null Het
Scel A G 14: 103,849,827 (GRCm39) I631V probably benign Het
Scn3a T A 2: 65,300,503 (GRCm39) M1288L probably benign Het
Serpina11 T A 12: 103,952,329 (GRCm39) D147V probably damaging Het
Shroom3 T A 5: 93,096,311 (GRCm39) C1266S probably benign Het
Slc12a7 A G 13: 73,962,962 (GRCm39) Y1054C probably damaging Het
Srms A G 2: 180,854,216 (GRCm39) V117A probably damaging Het
Tmem161b T C 13: 84,370,541 (GRCm39) probably benign Het
Tmem94 A T 11: 115,681,110 (GRCm39) T158S probably benign Het
Tomm40l T C 1: 171,047,878 (GRCm39) probably null Het
Traf6 A G 2: 101,515,128 (GRCm39) I95V probably benign Het
Ttc13 A G 8: 125,402,085 (GRCm39) I686T probably damaging Het
Zmat2 C T 18: 36,929,163 (GRCm39) H104Y probably damaging Het
Other mutations in Clip4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00417:Clip4 APN 17 72,156,937 (GRCm39) missense probably damaging 1.00
IGL01011:Clip4 APN 17 72,156,934 (GRCm39) missense probably benign 0.02
IGL01712:Clip4 APN 17 72,106,036 (GRCm39) missense probably damaging 1.00
IGL01833:Clip4 APN 17 72,134,785 (GRCm39) unclassified probably benign
IGL02150:Clip4 APN 17 72,106,071 (GRCm39) missense probably damaging 1.00
IGL02378:Clip4 APN 17 72,144,721 (GRCm39) missense possibly damaging 0.94
IGL02597:Clip4 APN 17 72,156,965 (GRCm39) splice site probably benign
IGL02676:Clip4 APN 17 72,135,616 (GRCm39) missense probably damaging 1.00
PIT4243001:Clip4 UTSW 17 72,113,723 (GRCm39) missense probably damaging 0.98
R0525:Clip4 UTSW 17 72,106,093 (GRCm39) critical splice donor site probably null
R0737:Clip4 UTSW 17 72,144,694 (GRCm39) nonsense probably null
R1791:Clip4 UTSW 17 72,108,937 (GRCm39) splice site probably benign
R1908:Clip4 UTSW 17 72,144,744 (GRCm39) missense probably damaging 1.00
R2290:Clip4 UTSW 17 72,117,948 (GRCm39) missense possibly damaging 0.96
R3701:Clip4 UTSW 17 72,106,003 (GRCm39) missense probably damaging 0.96
R4001:Clip4 UTSW 17 72,106,071 (GRCm39) missense probably damaging 1.00
R4013:Clip4 UTSW 17 72,163,541 (GRCm39) nonsense probably null
R4589:Clip4 UTSW 17 72,117,862 (GRCm39) nonsense probably null
R4837:Clip4 UTSW 17 72,141,217 (GRCm39) missense probably damaging 1.00
R5174:Clip4 UTSW 17 72,117,957 (GRCm39) missense probably damaging 1.00
R5239:Clip4 UTSW 17 72,106,072 (GRCm39) missense probably damaging 1.00
R5298:Clip4 UTSW 17 72,141,220 (GRCm39) missense probably damaging 1.00
R5535:Clip4 UTSW 17 72,138,257 (GRCm39) missense probably benign
R5667:Clip4 UTSW 17 72,096,878 (GRCm39) start codon destroyed probably damaging 1.00
R5671:Clip4 UTSW 17 72,096,878 (GRCm39) start codon destroyed probably damaging 1.00
R5730:Clip4 UTSW 17 72,117,954 (GRCm39) missense probably damaging 1.00
R5768:Clip4 UTSW 17 72,113,494 (GRCm39) splice site probably null
R5913:Clip4 UTSW 17 72,131,760 (GRCm39) missense probably benign 0.00
R5974:Clip4 UTSW 17 72,138,242 (GRCm39) missense probably damaging 1.00
R5996:Clip4 UTSW 17 72,163,305 (GRCm39) missense probably damaging 0.99
R6176:Clip4 UTSW 17 72,113,628 (GRCm39) nonsense probably null
R6371:Clip4 UTSW 17 72,163,459 (GRCm39) missense probably damaging 1.00
R6386:Clip4 UTSW 17 72,141,189 (GRCm39) nonsense probably null
R7296:Clip4 UTSW 17 72,096,996 (GRCm39) missense probably damaging 0.99
R7546:Clip4 UTSW 17 72,135,697 (GRCm39) missense possibly damaging 0.85
R7548:Clip4 UTSW 17 72,096,963 (GRCm39) missense probably benign
R7616:Clip4 UTSW 17 72,141,268 (GRCm39) missense probably benign 0.00
R8054:Clip4 UTSW 17 72,141,268 (GRCm39) missense possibly damaging 0.68
R8056:Clip4 UTSW 17 72,110,587 (GRCm39) missense probably damaging 1.00
R8486:Clip4 UTSW 17 72,170,839 (GRCm39) utr 3 prime probably benign
R8697:Clip4 UTSW 17 72,163,270 (GRCm39) missense possibly damaging 0.80
R8812:Clip4 UTSW 17 72,107,800 (GRCm39) nonsense probably null
R8929:Clip4 UTSW 17 72,138,203 (GRCm39) missense probably damaging 1.00
R8942:Clip4 UTSW 17 72,170,768 (GRCm39) missense probably benign 0.03
R8985:Clip4 UTSW 17 72,113,527 (GRCm39) missense probably damaging 1.00
R9100:Clip4 UTSW 17 72,117,884 (GRCm39) missense probably damaging 1.00
R9198:Clip4 UTSW 17 72,117,884 (GRCm39) missense probably damaging 1.00
R9200:Clip4 UTSW 17 72,117,884 (GRCm39) missense probably damaging 1.00
R9201:Clip4 UTSW 17 72,117,884 (GRCm39) missense probably damaging 1.00
R9202:Clip4 UTSW 17 72,117,884 (GRCm39) missense probably damaging 1.00
R9640:Clip4 UTSW 17 72,163,264 (GRCm39) missense possibly damaging 0.86
R9753:Clip4 UTSW 17 72,106,068 (GRCm39) missense probably benign 0.31
Z1177:Clip4 UTSW 17 72,106,092 (GRCm39) critical splice donor site probably null
Posted On 2013-06-21