Incidental Mutation 'IGL01093:Vmn1r225'
ID53049
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r225
Ensembl Gene ENSMUSG00000043537
Gene Namevomeronasal 1 receptor 225
SynonymsV1re5
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01093
Quality Score
Status
Chromosome17
Chromosomal Location20502299-20503195 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 20502819 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 174 (D174V)
Ref Sequence ENSEMBL: ENSMUSP00000056068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061660]
Predicted Effect probably damaging
Transcript: ENSMUST00000061660
AA Change: D174V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000056068
Gene: ENSMUSG00000043537
AA Change: D174V

DomainStartEndE-ValueType
Pfam:TAS2R 1 287 8.9e-15 PFAM
Pfam:V1R 11 291 3.1e-24 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402H24Rik T C 2: 130,777,236 T281A probably benign Het
Akr1c21 C T 13: 4,581,140 probably benign Het
Alpk2 A G 18: 65,349,329 L69P probably damaging Het
C3 G T 17: 57,223,949 P384Q probably damaging Het
Cobll1 T C 2: 65,098,237 E953G probably damaging Het
Dnmt1 C T 9: 20,909,785 E1269K possibly damaging Het
Dync2h1 T C 9: 7,145,611 R1012G probably benign Het
Fbxw24 T A 9: 109,604,973 Q423L probably benign Het
Flg2 T C 3: 93,202,371 S569P unknown Het
Ier5 A G 1: 155,099,393 I13T probably damaging Het
Kat6a A G 8: 22,939,321 D1564G possibly damaging Het
Lcn5 T C 2: 25,660,717 V139A probably benign Het
Naca A G 10: 128,048,113 S2138G probably damaging Het
Olfr1137 T G 2: 87,711,133 M258L possibly damaging Het
Olfr344 T G 2: 36,568,826 V76G probably damaging Het
Olfr483 T A 7: 108,103,644 S112T probably benign Het
Olfr798 A C 10: 129,625,563 F166C probably damaging Het
Olfr821 A G 10: 130,033,892 T89A probably benign Het
Pcdhgb8 A G 18: 37,825,036 T813A probably damaging Het
Pkd1l1 T C 11: 8,901,345 T696A probably benign Het
Rif1 T G 2: 52,095,948 H648Q probably damaging Het
Secisbp2l C A 2: 125,740,325 K1070N probably benign Het
Spock3 G A 8: 63,348,959 R327Q probably benign Het
Trpm2 A G 10: 77,932,280 I795T probably benign Het
Ube4b T C 4: 149,330,269 I1128V probably benign Het
Xpnpep3 T A 15: 81,436,768 Y283N possibly damaging Het
Zfp9 C T 6: 118,465,839 A99T probably benign Het
Zfp944 A G 17: 22,343,634 probably benign Het
Zscan4c G A 7: 11,009,617 C381Y probably benign Het
Other mutations in Vmn1r225
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01830:Vmn1r225 APN 17 20502455 missense probably damaging 0.96
IGL02943:Vmn1r225 APN 17 20502305 missense possibly damaging 0.67
R0544:Vmn1r225 UTSW 17 20502456 missense probably benign 0.44
R1126:Vmn1r225 UTSW 17 20502326 missense probably benign 0.03
R1809:Vmn1r225 UTSW 17 20502656 missense probably benign 0.04
R1928:Vmn1r225 UTSW 17 20502809 missense probably benign 0.00
R2044:Vmn1r225 UTSW 17 20502590 missense possibly damaging 0.50
R2191:Vmn1r225 UTSW 17 20502885 missense probably damaging 0.98
R2206:Vmn1r225 UTSW 17 20502349 missense possibly damaging 0.56
R2207:Vmn1r225 UTSW 17 20502349 missense possibly damaging 0.56
R2680:Vmn1r225 UTSW 17 20502793 missense probably benign 0.00
R3740:Vmn1r225 UTSW 17 20502999 missense possibly damaging 0.56
R3807:Vmn1r225 UTSW 17 20502852 nonsense probably null
R4196:Vmn1r225 UTSW 17 20502975 missense probably benign 0.00
R4970:Vmn1r225 UTSW 17 20502569 missense possibly damaging 0.74
R5129:Vmn1r225 UTSW 17 20503116 missense probably damaging 1.00
R5130:Vmn1r225 UTSW 17 20502785 missense possibly damaging 0.81
R5187:Vmn1r225 UTSW 17 20502915 missense probably damaging 0.96
R5580:Vmn1r225 UTSW 17 20502839 missense probably damaging 1.00
R6563:Vmn1r225 UTSW 17 20502501 missense probably benign 0.03
R6674:Vmn1r225 UTSW 17 20503115 missense probably benign 0.06
R7003:Vmn1r225 UTSW 17 20503154 missense probably null 0.01
R7143:Vmn1r225 UTSW 17 20502384 missense probably benign 0.22
R7422:Vmn1r225 UTSW 17 20502797 missense probably benign 0.25
R7651:Vmn1r225 UTSW 17 20502349 missense possibly damaging 0.56
R7952:Vmn1r225 UTSW 17 20502327 missense probably damaging 0.98
R8097:Vmn1r225 UTSW 17 20502349 missense possibly damaging 0.56
R8696:Vmn1r225 UTSW 17 20503157 missense probably damaging 1.00
R8823:Vmn1r225 UTSW 17 20502561 missense probably benign 0.08
Z1177:Vmn1r225 UTSW 17 20502491 missense possibly damaging 0.65
Posted On2013-06-21