|Institutional Source||Beutler Lab|
|Gene Name||WAS protein homolog associated with actin, golgi membranes and microtubules|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6747 (G1)|
|Chromosomal Location||81571266-81596836 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (1 bp from exon)|
|DNA Base Change (assembly)||G to A at 81578302 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000146854 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000165460] [ENSMUST00000207123] [ENSMUST00000209044]|
|Meta Mutation Damage Score||0.9596|
|Coding Region Coverage||
|Validation Efficiency||97% (68/70)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Whamm||
(F):5'- GTGGTTACAGCAGTCCACAC -3'
(R):5'- ACCACTTATGATGGCTGAACAAAC -3'
(F):5'- CAGACACTTCAGCATTTCCTAATGG -3'
(R):5'- CTTATGATGGCTGAACAAACACATC -3'