Mutagenetix > Incidental Mutation

Incidental Mutation 'R6747:Dmxl2'

530596

Institutional Source

Beutler Lab

Gene Symbol

Dmxl2

Ensembl Gene

ENSMUSG00000041268

Gene Name

Dmx-like 2

Synonyms

E130119P06Rik, 6430411K14Rik

MMRRC Submission

044864-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R6747 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

54365158-54501626 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 54416088 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 1337 (H1337Q)

Ref Sequence

ENSEMBL: ENSMUSP00000113705 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000118163] [ENSMUST00000118600] [ENSMUST00000127880]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000118163
AA Change: H1337Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000113705
Gene: ENSMUSG00000041268
AA Change: H1337Q

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
Pfam:Rav1p_C	1430	1903	1.5e-71	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2472	2490	N/A	INTRINSIC
low complexity region	2635	2649	N/A	INTRINSIC
low complexity region	2744	2766	N/A	INTRINSIC
WD40	2774	2809	5.73e0	SMART
WD40	2813	2852	8.88e0	SMART
WD40	2859	2901	2.67e-1	SMART
WD40	2907	2946	2.57e-2	SMART
WD40	2949	2988	3.61e-6	SMART
WD40	3001	3039	8.25e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000118600
AA Change: H1337Q

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000113693
Gene: ENSMUSG00000041268
AA Change: H1337Q

Domain	Start	End	E-Value	Type
WD40	43	84	4.58e1	SMART
WD40	100	136	2.28e2	SMART
WD40	159	198	2.57e-2	SMART
WD40	221	269	1.03e-1	SMART
low complexity region	420	440	N/A	INTRINSIC
WD40	741	793	1.42e2	SMART
low complexity region	861	875	N/A	INTRINSIC
low complexity region	945	961	N/A	INTRINSIC
WD40	985	1029	1.15e1	SMART
WD40	1236	1273	2.84e2	SMART
low complexity region	1426	1436	N/A	INTRINSIC
Pfam:Rav1p_C	1447	1903	4.2e-68	PFAM
low complexity region	1978	1993	N/A	INTRINSIC
coiled coil region	2118	2146	N/A	INTRINSIC
low complexity region	2189	2204	N/A	INTRINSIC
low complexity region	2251	2266	N/A	INTRINSIC
low complexity region	2471	2489	N/A	INTRINSIC
low complexity region	2722	2744	N/A	INTRINSIC
WD40	2752	2787	5.73e0	SMART
WD40	2791	2830	8.88e0	SMART
WD40	2837	2879	2.67e-1	SMART
WD40	2885	2924	2.57e-2	SMART
WD40	2927	2966	3.61e-6	SMART
WD40	2979	3017	8.25e0	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000123709
AA Change: H538Q

SMART Domains

Protein: ENSMUSP00000119959
Gene: ENSMUSG00000041268
AA Change: H538Q

Domain	Start	End	E-Value	Type
low complexity region	63	77	N/A	INTRINSIC
low complexity region	147	163	N/A	INTRINSIC
WD40	187	231	1.15e1	SMART
WD40	438	475	2.84e2	SMART
Pfam:Rav1p_C	632	1105	9.1e-72	PFAM
low complexity region	1180	1195	N/A	INTRINSIC
coiled coil region	1319	1347	N/A	INTRINSIC
low complexity region	1391	1406	N/A	INTRINSIC
low complexity region	1453	1468	N/A	INTRINSIC
low complexity region	1674	1692	N/A	INTRINSIC
low complexity region	1925	1947	N/A	INTRINSIC
WD40	1955	1990	5.73e0	SMART
WD40	1994	2033	8.88e0	SMART
WD40	2040	2082	2.67e-1	SMART
WD40	2088	2127	2.57e-2	SMART
WD40	2130	2169	3.61e-6	SMART
WD40	2182	2220	8.25e0	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000127880
AA Change: H1163Q

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000122293
Gene: ENSMUSG00000041268
AA Change: H1163Q

Domain	Start	End	E-Value	Type
Pfam:WD40	1	24	7.9e-4	PFAM
WD40	47	95	1.03e-1	SMART
low complexity region	246	266	N/A	INTRINSIC
WD40	567	619	1.42e2	SMART
low complexity region	687	701	N/A	INTRINSIC
low complexity region	771	787	N/A	INTRINSIC
WD40	811	855	1.15e1	SMART
WD40	1062	1099	2.84e2	SMART
low complexity region	1252	1262	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.5%
20x: 96.0%

Validation Efficiency

97% (68/70)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete prenatal lethality. [provided by MGI curators]

Allele List at MGI

All alleles(4) : Targeted(2) Gene trapped(2)

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	C	T	3: 122,126,313 (GRCm38)		probably null	Het
Acyp1	C	T	12: 85,278,905 (GRCm38)	V107I	probably null	Het
Aftph	T	C	11: 20,726,144 (GRCm38)		probably null	Het
Agtpbp1	A	T	13: 59,544,353 (GRCm38)		probably null	Het
Arhgap15	C	A	2: 44,116,677 (GRCm38)	P269T	probably damaging	Het
Arhgap30	T	C	1: 171,407,729 (GRCm38)	V557A	probably damaging	Het
Asb3	T	A	11: 31,081,493 (GRCm38)	M410K	probably benign	Het
B4galnt2	T	C	11: 95,868,634 (GRCm38)		probably null	Het
Birc3	A	G	9: 7,860,261 (GRCm38)		probably null	Het
Cav2	A	T	6: 17,286,951 (GRCm38)	N69Y	probably damaging	Het
Cc2d2b	G	A	19: 40,795,667 (GRCm38)	C826Y	probably benign	Het
Cenpf	T	A	1: 189,652,854 (GRCm38)	T2410S	probably benign	Het
Chchd1	A	G	14: 20,703,380 (GRCm38)	D24G	probably benign	Het
Cmip	G	A	8: 117,436,879 (GRCm38)	G450S	probably benign	Het
Col11a1	C	T	3: 114,212,450 (GRCm38)	Q534*	probably null	Het
Col3a1	G	T	1: 45,338,622 (GRCm38)		probably benign	Het
Cox4i1	T	C	8: 120,673,230 (GRCm38)	I31T	possibly damaging	Het
Cstf3	G	T	2: 104,646,767 (GRCm38)	V168F	probably damaging	Het
Dapk1	T	C	13: 60,725,340 (GRCm38)	I352T	probably benign	Het
Ddx52	T	C	11: 83,955,302 (GRCm38)	V456A	probably damaging	Het
Dnah7a	T	C	1: 53,636,062 (GRCm38)	T369A	probably benign	Het
Dppa1	T	A	11: 46,625,595 (GRCm38)	I8F	unknown	Het
Ebf1	G	T	11: 44,883,814 (GRCm38)	V213F	probably damaging	Het
Foxb2	C	A	19: 16,872,833 (GRCm38)	E270*	probably null	Het
Gclc	A	T	9: 77,788,245 (GRCm38)	R450W	probably damaging	Het
Gm13128	T	C	4: 144,332,978 (GRCm38)	W420R	probably benign	Het
Grin2d	T	C	7: 45,862,268 (GRCm38)	E251G	probably damaging	Het
Hal	A	T	10: 93,500,677 (GRCm38)	N423Y	probably damaging	Het
Krtap4-8	T	A	11: 99,780,091 (GRCm38)	I185F	unknown	Het
Lrp3	T	A	7: 35,211,437 (GRCm38)	Q61L	probably benign	Het
Met	A	C	6: 17,571,467 (GRCm38)	Q1296H	probably damaging	Het
Mphosph9	T	A	5: 124,297,699 (GRCm38)	N557I	possibly damaging	Het
Mrpl46	C	A	7: 78,782,981 (GRCm38)	W16C	probably benign	Het
Myh13	G	A	11: 67,350,419 (GRCm38)	R874Q	probably damaging	Het
Nelfb	G	A	2: 25,203,381 (GRCm38)	T453I	probably benign	Het
Nos2	A	G	11: 78,952,954 (GRCm38)	D909G	probably damaging	Het
Nr5a2	T	C	1: 136,882,344 (GRCm38)	E431G	possibly damaging	Het
Nsmce2	A	G	15: 59,591,724 (GRCm38)	D149G	probably benign	Het
Olfr203	T	C	16: 59,303,641 (GRCm38)	F164L	probably benign	Het
Olfr690	C	T	7: 105,330,027 (GRCm38)	R55H	probably benign	Het
Pcbp4	C	A	9: 106,460,648 (GRCm38)		probably null	Het
Peg10	A	G	6: 4,757,137 (GRCm38)		probably benign	Het
Pms2	C	T	5: 143,925,419 (GRCm38)	P154L	probably benign	Het
Pou6f2	A	C	13: 18,129,187 (GRCm38)	L112R	probably benign	Het
Prdm6	A	T	18: 53,465,046 (GRCm38)		probably benign	Het
Prob1	G	A	18: 35,655,154 (GRCm38)	R12W	probably damaging	Het
Rif1	T	A	2: 52,078,263 (GRCm38)		probably null	Het
Rpl9-ps6	A	G	19: 32,466,143 (GRCm38)	S137P	probably benign	Het
Rsf1	GGCG	GGCGACGGCAGCG	7: 97,579,906 (GRCm38)		probably benign	Homo
Sec23ip	A	G	7: 128,752,849 (GRCm38)		silent	Het
Slc38a9	T	C	13: 112,690,180 (GRCm38)	C151R	probably benign	Het
Slc39a8	T	C	3: 135,849,180 (GRCm38)		probably null	Het
Slc6a18	C	A	13: 73,677,991 (GRCm38)		probably benign	Het
Snw1	T	C	12: 87,464,710 (GRCm38)	D57G	probably damaging	Het
Sox6	C	G	7: 115,541,731 (GRCm38)	R505P	probably damaging	Het
Speg	T	C	1: 75,410,395 (GRCm38)		probably null	Het
Spire2	C	T	8: 123,356,846 (GRCm38)	R190C	probably damaging	Het
Stard9	A	C	2: 120,698,383 (GRCm38)	H1707P	possibly damaging	Het
Tenm3	G	T	8: 48,343,243 (GRCm38)	T237K	probably damaging	Het
Themis2	T	A	4: 132,796,262 (GRCm38)	E31V	possibly damaging	Het
Trim56	T	G	5: 137,114,521 (GRCm38)	Q47P	probably damaging	Het
Trim58	T	C	11: 58,651,264 (GRCm38)	I350T	probably benign	Het
Ttll7	C	T	3: 146,944,056 (GRCm38)	P639S	probably benign	Het
Ubxn6	A	G	17: 56,070,650 (GRCm38)		probably null	Het
Vmn2r114	A	T	17: 23,309,876 (GRCm38)	F417L	probably benign	Het
Vmn2r29	T	A	7: 7,231,422 (GRCm38)	M822L	probably benign	Het
Vps9d1	T	C	8: 123,254,007 (GRCm38)	D27G	probably damaging	Het
Wdr3	C	T	3: 100,138,724 (GRCm38)	R931Q	probably damaging	Het
Whamm	G	A	7: 81,578,302 (GRCm38)		probably null	Het
Zcchc24	T	C	14: 25,757,033 (GRCm38)	H142R	probably damaging	Het
Zfp292	T	C	4: 34,806,894 (GRCm38)	K2050R	probably damaging	Het

Other mutations in Dmxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Dmxl2	APN	9	54,401,704 (GRCm38)	missense	probably benign
IGL00226:Dmxl2	APN	9	54,415,993 (GRCm38)	missense	probably damaging	1.00
IGL00419:Dmxl2	APN	9	54,406,667 (GRCm38)	missense	probably damaging	0.96
IGL00551:Dmxl2	APN	9	54,450,838 (GRCm38)	missense	probably damaging	1.00
IGL00765:Dmxl2	APN	9	54,415,422 (GRCm38)	unclassified	probably benign
IGL00852:Dmxl2	APN	9	54,423,313 (GRCm38)	nonsense	probably null
IGL00857:Dmxl2	APN	9	54,376,320 (GRCm38)	missense	probably benign	0.32
IGL00952:Dmxl2	APN	9	54,416,882 (GRCm38)	missense	probably damaging	0.99
IGL01139:Dmxl2	APN	9	54,458,964 (GRCm38)	missense	probably damaging	1.00
IGL01346:Dmxl2	APN	9	54,415,475 (GRCm38)	missense	probably damaging	1.00
IGL01538:Dmxl2	APN	9	54,445,376 (GRCm38)	splice site	probably benign
IGL01645:Dmxl2	APN	9	54,378,733 (GRCm38)	missense	possibly damaging	0.93
IGL02096:Dmxl2	APN	9	54,401,065 (GRCm38)	missense	possibly damaging	0.89
IGL02104:Dmxl2	APN	9	54,404,015 (GRCm38)	nonsense	probably null
IGL02145:Dmxl2	APN	9	54,374,697 (GRCm38)	missense	probably benign	0.29
IGL02210:Dmxl2	APN	9	54,404,049 (GRCm38)	missense	probably damaging	1.00
IGL02238:Dmxl2	APN	9	54,445,433 (GRCm38)	missense	probably damaging	1.00
IGL02255:Dmxl2	APN	9	54,393,768 (GRCm38)	missense	probably benign	0.06
IGL02364:Dmxl2	APN	9	54,393,843 (GRCm38)	missense	probably benign	0.02
IGL02423:Dmxl2	APN	9	54,393,748 (GRCm38)	missense	possibly damaging	0.89
IGL02440:Dmxl2	APN	9	54,406,615 (GRCm38)	missense	probably damaging	0.98
IGL02546:Dmxl2	APN	9	54,366,414 (GRCm38)	utr 3 prime	probably benign
IGL02668:Dmxl2	APN	9	54,416,945 (GRCm38)	missense	probably damaging	1.00
IGL03229:Dmxl2	APN	9	54,404,172 (GRCm38)	missense	probably damaging	1.00
IGL03244:Dmxl2	APN	9	54,416,371 (GRCm38)	missense	probably damaging	1.00
IGL03277:Dmxl2	APN	9	54,404,220 (GRCm38)	missense	probably damaging	1.00
IGL03399:Dmxl2	APN	9	54,446,672 (GRCm38)	missense	probably damaging	1.00
BB003:Dmxl2	UTSW	9	54,428,042 (GRCm38)	missense	probably benign	0.01
BB013:Dmxl2	UTSW	9	54,428,042 (GRCm38)	missense	probably benign	0.01
I2288:Dmxl2	UTSW	9	54,401,793 (GRCm38)	missense	probably damaging	1.00
P0014:Dmxl2	UTSW	9	54,401,764 (GRCm38)	missense	probably damaging	1.00
R0411:Dmxl2	UTSW	9	54,378,939 (GRCm38)	missense	probably damaging	1.00
R0422:Dmxl2	UTSW	9	54,399,940 (GRCm38)	critical splice donor site	probably null
R0432:Dmxl2	UTSW	9	54,416,951 (GRCm38)	missense	probably benign	0.01
R0436:Dmxl2	UTSW	9	54,383,750 (GRCm38)	missense	probably damaging	1.00
R0538:Dmxl2	UTSW	9	54,393,836 (GRCm38)	missense	probably benign	0.06
R0603:Dmxl2	UTSW	9	54,405,906 (GRCm38)	missense	possibly damaging	0.95
R0605:Dmxl2	UTSW	9	54,419,945 (GRCm38)	missense	probably benign	0.01
R0625:Dmxl2	UTSW	9	54,382,702 (GRCm38)	missense	probably benign
R0626:Dmxl2	UTSW	9	54,416,554 (GRCm38)	missense	probably damaging	1.00
R0736:Dmxl2	UTSW	9	54,378,817 (GRCm38)	missense	probably damaging	0.99
R0847:Dmxl2	UTSW	9	54,405,828 (GRCm38)	missense	probably damaging	1.00
R0855:Dmxl2	UTSW	9	54,366,440 (GRCm38)	missense	probably benign	0.03
R0962:Dmxl2	UTSW	9	54,446,412 (GRCm38)	missense	probably damaging	0.99
R1015:Dmxl2	UTSW	9	54,367,765 (GRCm38)	missense	probably benign	0.32
R1084:Dmxl2	UTSW	9	54,416,433 (GRCm38)	missense	probably damaging	1.00
R1328:Dmxl2	UTSW	9	54,396,249 (GRCm38)	missense	probably benign	0.12
R1401:Dmxl2	UTSW	9	54,415,428 (GRCm38)	critical splice donor site	probably null
R1503:Dmxl2	UTSW	9	54,446,988 (GRCm38)	nonsense	probably null
R1609:Dmxl2	UTSW	9	54,409,263 (GRCm38)	missense	possibly damaging	0.90
R1613:Dmxl2	UTSW	9	54,382,027 (GRCm38)	missense	probably benign
R1660:Dmxl2	UTSW	9	54,451,030 (GRCm38)	missense	possibly damaging	0.68
R1712:Dmxl2	UTSW	9	54,401,485 (GRCm38)	missense	probably benign	0.00
R1772:Dmxl2	UTSW	9	54,423,224 (GRCm38)	splice site	probably benign
R1832:Dmxl2	UTSW	9	54,460,949 (GRCm38)	missense	probably damaging	0.97
R1922:Dmxl2	UTSW	9	54,401,523 (GRCm38)	missense	probably benign
R2104:Dmxl2	UTSW	9	54,415,564 (GRCm38)	missense	probably damaging	1.00
R2109:Dmxl2	UTSW	9	54,393,813 (GRCm38)	missense	probably benign	0.06
R2145:Dmxl2	UTSW	9	54,415,910 (GRCm38)	missense	probably damaging	1.00
R2199:Dmxl2	UTSW	9	54,376,243 (GRCm38)	missense	probably benign	0.35
R2352:Dmxl2	UTSW	9	54,393,862 (GRCm38)	missense	probably damaging	1.00
R2516:Dmxl2	UTSW	9	54,400,094 (GRCm38)	missense	probably damaging	1.00
R2981:Dmxl2	UTSW	9	54,393,702 (GRCm38)	missense	probably damaging	1.00
R3430:Dmxl2	UTSW	9	54,477,461 (GRCm38)	missense	possibly damaging	0.94
R3625:Dmxl2	UTSW	9	54,393,643 (GRCm38)	missense	probably benign	0.23
R3725:Dmxl2	UTSW	9	54,393,769 (GRCm38)	missense	probably damaging	1.00
R3787:Dmxl2	UTSW	9	54,369,878 (GRCm38)	missense	probably damaging	1.00
R4002:Dmxl2	UTSW	9	54,473,832 (GRCm38)	splice site	probably benign
R4004:Dmxl2	UTSW	9	54,446,390 (GRCm38)	missense	probably benign	0.04
R4005:Dmxl2	UTSW	9	54,446,390 (GRCm38)	missense	probably benign	0.04
R4012:Dmxl2	UTSW	9	54,379,013 (GRCm38)	splice site	probably null
R4014:Dmxl2	UTSW	9	54,378,709 (GRCm38)	splice site	probably null
R4115:Dmxl2	UTSW	9	54,446,988 (GRCm38)	nonsense	probably null
R4232:Dmxl2	UTSW	9	54,419,909 (GRCm38)	missense	possibly damaging	0.89
R4388:Dmxl2	UTSW	9	54,396,267 (GRCm38)	missense	probably damaging	1.00
R4513:Dmxl2	UTSW	9	54,419,884 (GRCm38)	missense	probably null	0.17
R4552:Dmxl2	UTSW	9	54,451,763 (GRCm38)	missense	probably damaging	1.00
R4609:Dmxl2	UTSW	9	54,446,512 (GRCm38)	missense	probably damaging	1.00
R4625:Dmxl2	UTSW	9	54,404,120 (GRCm38)	missense	possibly damaging	0.55
R4694:Dmxl2	UTSW	9	54,446,905 (GRCm38)	missense	probably benign	0.04
R4711:Dmxl2	UTSW	9	54,450,924 (GRCm38)	missense	probably benign	0.37
R4715:Dmxl2	UTSW	9	54,446,405 (GRCm38)	splice site	probably null
R4746:Dmxl2	UTSW	9	54,451,796 (GRCm38)	missense	probably benign	0.04
R4789:Dmxl2	UTSW	9	54,379,815 (GRCm38)	missense	probably benign	0.30
R4825:Dmxl2	UTSW	9	54,404,041 (GRCm38)	missense	probably benign	0.01
R4911:Dmxl2	UTSW	9	54,411,653 (GRCm38)	missense	probably damaging	1.00
R4995:Dmxl2	UTSW	9	54,501,441 (GRCm38)	utr 5 prime	probably benign
R5026:Dmxl2	UTSW	9	54,416,676 (GRCm38)	missense	probably damaging	1.00
R5118:Dmxl2	UTSW	9	54,460,987 (GRCm38)	missense	probably damaging	1.00
R5174:Dmxl2	UTSW	9	54,445,484 (GRCm38)	splice site	probably null
R5288:Dmxl2	UTSW	9	54,378,757 (GRCm38)	missense	probably benign
R5373:Dmxl2	UTSW	9	54,369,189 (GRCm38)	intron	probably benign
R5374:Dmxl2	UTSW	9	54,369,189 (GRCm38)	intron	probably benign
R5385:Dmxl2	UTSW	9	54,378,757 (GRCm38)	missense	probably benign
R5386:Dmxl2	UTSW	9	54,378,757 (GRCm38)	missense	probably benign
R5418:Dmxl2	UTSW	9	54,374,651 (GRCm38)	critical splice donor site	probably null
R5540:Dmxl2	UTSW	9	54,393,857 (GRCm38)	missense	probably benign	0.21
R5568:Dmxl2	UTSW	9	54,423,359 (GRCm38)	splice site	probably null
R5733:Dmxl2	UTSW	9	54,376,266 (GRCm38)	missense	possibly damaging	0.64
R5758:Dmxl2	UTSW	9	54,472,964 (GRCm38)	missense	probably benign	0.28
R5759:Dmxl2	UTSW	9	54,375,508 (GRCm38)	missense	probably damaging	1.00
R5893:Dmxl2	UTSW	9	54,387,420 (GRCm38)	missense	possibly damaging	0.64
R6030:Dmxl2	UTSW	9	54,393,673 (GRCm38)	missense	probably benign	0.18
R6030:Dmxl2	UTSW	9	54,393,673 (GRCm38)	missense	probably benign	0.18
R6041:Dmxl2	UTSW	9	54,416,753 (GRCm38)	missense	probably damaging	1.00
R6174:Dmxl2	UTSW	9	54,393,727 (GRCm38)	missense	probably damaging	1.00
R6278:Dmxl2	UTSW	9	54,415,762 (GRCm38)	missense	probably damaging	1.00
R6307:Dmxl2	UTSW	9	54,382,706 (GRCm38)	missense	possibly damaging	0.68
R6349:Dmxl2	UTSW	9	54,419,909 (GRCm38)	missense	possibly damaging	0.89
R6404:Dmxl2	UTSW	9	54,375,536 (GRCm38)	missense	probably damaging	1.00
R6516:Dmxl2	UTSW	9	54,416,676 (GRCm38)	missense	probably damaging	1.00
R6712:Dmxl2	UTSW	9	54,411,624 (GRCm38)	missense	probably damaging	1.00
R6769:Dmxl2	UTSW	9	54,416,524 (GRCm38)	missense	probably damaging	1.00
R6771:Dmxl2	UTSW	9	54,416,524 (GRCm38)	missense	probably damaging	1.00
R6800:Dmxl2	UTSW	9	54,409,183 (GRCm38)	missense	probably damaging	1.00
R6891:Dmxl2	UTSW	9	54,480,380 (GRCm38)	missense	probably damaging	0.99
R6920:Dmxl2	UTSW	9	54,472,212 (GRCm38)	missense	probably damaging	1.00
R6979:Dmxl2	UTSW	9	54,450,879 (GRCm38)	missense	possibly damaging	0.49
R7147:Dmxl2	UTSW	9	54,416,729 (GRCm38)	missense	probably benign	0.06
R7327:Dmxl2	UTSW	9	54,401,585 (GRCm38)	missense	probably damaging	1.00
R7462:Dmxl2	UTSW	9	54,366,632 (GRCm38)	splice site	probably null
R7526:Dmxl2	UTSW	9	54,400,957 (GRCm38)	missense	possibly damaging	0.47
R7569:Dmxl2	UTSW	9	54,415,987 (GRCm38)	missense	possibly damaging	0.51
R7622:Dmxl2	UTSW	9	54,472,218 (GRCm38)	missense	probably damaging	0.99
R7638:Dmxl2	UTSW	9	54,457,794 (GRCm38)	missense	unknown
R7703:Dmxl2	UTSW	9	54,461,086 (GRCm38)	missense	probably benign	0.01
R7768:Dmxl2	UTSW	9	54,380,939 (GRCm38)	missense	probably damaging	1.00
R7926:Dmxl2	UTSW	9	54,428,042 (GRCm38)	missense	probably benign	0.01
R7969:Dmxl2	UTSW	9	54,446,881 (GRCm38)	missense	possibly damaging	0.85
R8007:Dmxl2	UTSW	9	54,383,691 (GRCm38)	nonsense	probably null
R8200:Dmxl2	UTSW	9	54,480,346 (GRCm38)	missense	probably benign
R8311:Dmxl2	UTSW	9	54,446,933 (GRCm38)	missense	probably benign	0.00
R8320:Dmxl2	UTSW	9	54,383,759 (GRCm38)	missense	probably benign
R8377:Dmxl2	UTSW	9	54,378,748 (GRCm38)	missense	probably damaging	1.00
R8400:Dmxl2	UTSW	9	54,383,753 (GRCm38)	missense	probably benign	0.03
R8509:Dmxl2	UTSW	9	54,428,057 (GRCm38)	nonsense	probably null
R8698:Dmxl2	UTSW	9	54,374,669 (GRCm38)	missense	probably benign	0.10
R8768:Dmxl2	UTSW	9	54,393,821 (GRCm38)	missense	possibly damaging	0.83
R8770:Dmxl2	UTSW	9	54,404,014 (GRCm38)	missense	probably benign	0.01
R8799:Dmxl2	UTSW	9	54,419,743 (GRCm38)	critical splice donor site	probably null
R8840:Dmxl2	UTSW	9	54,401,855 (GRCm38)	missense	possibly damaging	0.58
R8898:Dmxl2	UTSW	9	54,401,657 (GRCm38)	missense	probably benign	0.01
R8954:Dmxl2	UTSW	9	54,473,872 (GRCm38)	missense	probably benign	0.04
R9083:Dmxl2	UTSW	9	54,409,264 (GRCm38)	missense	probably benign	0.29
R9114:Dmxl2	UTSW	9	54,400,037 (GRCm38)	missense
R9115:Dmxl2	UTSW	9	54,401,727 (GRCm38)	missense	probably benign
R9263:Dmxl2	UTSW	9	54,451,661 (GRCm38)	missense	probably benign	0.01
R9272:Dmxl2	UTSW	9	54,404,120 (GRCm38)	missense	possibly damaging	0.55
R9577:Dmxl2	UTSW	9	54,416,380 (GRCm38)	missense	unknown
R9673:Dmxl2	UTSW	9	54,387,556 (GRCm38)	missense	probably damaging	1.00
R9722:Dmxl2	UTSW	9	54,416,608 (GRCm38)	missense	probably benign	0.00
R9726:Dmxl2	UTSW	9	54,415,712 (GRCm38)	missense	probably benign	0.09
R9797:Dmxl2	UTSW	9	54,450,903 (GRCm38)	missense	probably benign	0.00
X0064:Dmxl2	UTSW	9	54,401,713 (GRCm38)	missense	probably benign
Z1177:Dmxl2	UTSW	9	54,382,034 (GRCm38)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TGCCGCTCACACTAATGGTC -3'
(R):5'- CATGTATATGCCCAATGGAAGC -3'

Sequencing Primer
(F):5'- GCTCACACTAATGGTCCGAGAG -3'
(R):5'- TGCCCAATGGAAGCATTCTG -3'

Posted On

2018-08-01